ID HNFAB_XENLA Reviewed; 592 AA.
AC Q91739; P79924; Q05042;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2000, sequence version 2.
DT 27-MAR-2024, entry version 124.
DE RecName: Full=Hepatocyte nuclear factor 1-alpha-B;
DE Short=HNF-1-alpha-B;
DE Short=HNF-1A-B;
DE AltName: Full=LFB1;
DE AltName: Full=Transcription factor 1-B;
DE Short=TCF-1-B;
DE AltName: Full=XlFB1b;
GN Name=hnf1a-b; Synonyms=hnf1-b, lfb1b, tcf1-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Liver;
RX PubMed=8262383; DOI=10.1016/0378-1119(93)90102-9;
RA Zapp D., Bartkowski S., Zoidl C., Klein-Hitpass L., Ryffel G.U.;
RT "Genomic structure of the Xenopus laevis liver transcription factor LFB1.";
RL Gene 134:251-256(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=8417340; DOI=10.1128/mcb.13.1.421-431.1993;
RA Bartkowski S., Zapp D., Weber H., Eberle G., Zoidl C., Senkel S.,
RA Klein-Hitpass L., Ryffel G.U.;
RT "Developmental regulation and tissue distribution of the liver
RT transcription factor LFB1 (HNF1) in Xenopus laevis.";
RL Mol. Cell. Biol. 13:421-431(1993).
RN [3]
RP FUNCTION.
RX PubMed=8735941;
RA Weber H., Pogge von Strandmann E., Holewa B., Bartkowski S., Zapp D.,
RA Zoidl C., Ryffel G.U.;
RT "Regulation and function of the tissue-specific transcription factor HNF1
RT alpha (LFB1) during Xenopus development.";
RL Int. J. Dev. Biol. 40:297-304(1996).
CC -!- FUNCTION: Transcriptional activator that regulates the tissue specific
CC expression of multiple genes, especially in pancreas and liver (By
CC similarity). Binds to the hepatocyte specific promoter element HP1.
CC Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. {ECO:0000250,
CC ECO:0000269|PubMed:8735941}.
CC -!- SUBUNIT: Binds DNA as dimer. Forms a homodimer or heterodimer with
CC HNF1-alpha-A. Potentially also form a heterodimer with HNF1-beta.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Liver.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family. {ECO:0000305}.
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DR EMBL; X72983; CAA51488.1; ALT_SEQ; Genomic_DNA.
DR EMBL; X72984; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X72985; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X72986; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X72987; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X72988; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X72989; CAA51488.1; JOINED; Genomic_DNA.
DR EMBL; X64760; CAA46008.1; -; mRNA.
DR EMBL; X64761; CAA46009.1; -; mRNA.
DR EMBL; X64762; CAA46009.1; JOINED; mRNA.
DR PIR; JT0766; JT0766.
DR AlphaFoldDB; Q91739; -.
DR SMR; Q91739; -.
DR AGR; Xenbase:XB-GENE-6252640; -.
DR Xenbase; XB-GENE-6252640; hnf1a.L.
DR Proteomes; UP000186698; Genome assembly.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR023219; HNF1_dimer_N_dom_sf.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR PANTHER; PTHR11568:SF4; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF100957; Dimerization cofactor of HNF-1 alpha; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..592
FT /note="Hepatocyte nuclear factor 1-alpha-B"
FT /id="PRO_0000049120"
FT DOMAIN 1..32
FT /note="HNF-p1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01286"
FT DOMAIN 85..180
FT /note="POU-specific atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01285"
FT DNA_BIND 197..277
FT /note="Homeobox; HNF1-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..31
FT /note="Dimerization"
FT /evidence="ECO:0000250"
FT REGION 54..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..130
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 141..147
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 153..156
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 201..204
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 261..263
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 268..271
FT /note="Interaction with DNA"
FT /evidence="ECO:0000250"
FT REGION 284..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 195..203
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 305..329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 305
FT /note="P -> PGF (in Ref. 2; CAA46009)"
FT /evidence="ECO:0000305"
FT CONFLICT 356
FT /note="S -> C (in Ref. 2; CAA46009)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 592 AA; 64817 MW; BE1BA05DDA5F03F1 CRC64;
MASQLSYLQQ ELLRALLESG VTKEALKKAL ADGDNYAYPN VPLDDIRNLD EGDNCVQLPN
GLGEPQMSED ESSDDGGDFT PPIMKELERL SPEEAAHQKA VVERLLQEDP WHVAKLVKSY
LQQHNIPQRE VVDTTGLNQS HLSQHLNKGT PMKTQKRAAL YAWYVGKQRE IARQFTHAGH
SMITDDMSCD DVPNKKMRRN RFKWGPASQQ ILFQAYERQK NPSKEEREAL VEECNRAECL
QRGVSPSQAQ GLGSNLVTEV RVYNWFANSG KEEAFRHKLA MDTYNGQQSS AQPLSTHDLP
HGKTPRYTQD SSTDRSAAMA NSQSTLSPSA LEPSHILMNS DSKMVPVSGG SLPPVSTLTA
LHSLDHSQHT LGQTQNLIMA SLPSVMTIGT DSALGPAFSN PGSSTLVIGL ASQTQSVPVI
NSVGSSLTTL QSVQFSQQLH PSHQQPIVQQ VQSHMAQSPF MATMAQLQSP HALYSHKPEV
AQYTSAGFFP QTMVITDTSN LGTLTSLTPS KQVVSHHPTA HGDSPGSQLH NQDSSILHLH
PSHRLSPIPT VSSASLIHYH NSSSPENHSH LLSPSHNTID SFISTQMASS SQ
//
