ID OTX2_DANRE Reviewed; 289 AA.
AC Q91981;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=Homeobox protein OTX2;
DE Short=zOTX2;
DE AltName: Full=Orthodenticle homolog 2;
GN Name=otx2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AB;
RX PubMed=7898305; DOI=10.1016/0169-328x(94)90004-3;
RA Mori H., Miyazaki Y., Morita T., Nitta H., Mishina M.;
RT "Different spatio-temporal expressions of three otx homeoprotein
RT transcripts during zebrafish embryogenesis.";
RL Brain Res. Mol. Brain Res. 27:221-231(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7893604; DOI=10.1016/0925-4773(94)90062-0;
RA Li Y., Allende M.L., Finkelstein R., Weinberg E.S.;
RT "Expression of two zebrafish orthodenticle-related genes in the embryonic
RT brain.";
RL Mech. Dev. 48:229-244(1994).
CC -!- FUNCTION: May play a role in very early embryogenesis, gastrulation,
CC and the development and subdivision of the diencephalon and the
CC midbrain.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Appears at 9 hours of development, and at 12 hours
CC of development significant levels are found in the developing brain
CC posterior to ocular vesicles. Distributed mainly in the midbrain, part
CC of the diencephalon beneath the epiphysis and in the epiphysis at 18
CC hours of development. Found in the ventral part of the midbrain and in
CC the dorsal part of the diencephalon at 24 hours of development.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; D26173; BAA05159.1; -; mRNA.
DR EMBL; U14592; AAA78901.1; -; mRNA.
DR PIR; I51752; I51752.
DR RefSeq; NP_571326.1; NM_131251.1.
DR RefSeq; XP_005158940.1; XM_005158883.3.
DR RefSeq; XP_009291522.1; XM_009293247.2.
DR AlphaFoldDB; Q91981; -.
DR SMR; Q91981; -.
DR BioGRID; 78681; 1.
DR STRING; 7955.ENSDARP00000111153; -.
DR PaxDb; 7955-ENSDARP00000111153; -.
DR GeneID; 30501; -.
DR KEGG; dre:30501; -.
DR AGR; ZFIN:ZDB-GENE-980526-406; -.
DR CTD; 30501; -.
DR ZFIN; ZDB-GENE-980526-406; otx2b.
DR eggNOG; KOG2251; Eukaryota.
DR HOGENOM; CLU_064370_0_0_1; -.
DR InParanoid; Q91981; -.
DR OMA; NISMMSY; -.
DR OrthoDB; 2913621at2759; -.
DR PhylomeDB; Q91981; -.
DR TreeFam; TF351179; -.
DR PRO; PR:Q91981; -.
DR Proteomes; UP000000437; Chromosome 17.
DR Bgee; ENSDARG00000011235; Expressed in camera-type eye and 56 other cell types or tissues.
DR ExpressionAtlas; Q91981; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0097306; P:cellular response to alcohol; IDA:ZFIN.
DR GO; GO:0021549; P:cerebellum development; IGI:ZFIN.
DR GO; GO:0030902; P:hindbrain development; IGI:ZFIN.
DR GO; GO:0030901; P:midbrain development; IGI:ZFIN.
DR GO; GO:0030917; P:midbrain-hindbrain boundary development; IGI:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0003406; P:retinal pigment epithelium development; IGI:ZFIN.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003022; Otx2_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR PANTHER; PTHR45793; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45793:SF2; HOMEOBOX PROTEIN OTX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01257; OTX2HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..289
FT /note="Homeobox protein OTX2"
FT /id="PRO_0000049214"
FT DNA_BIND 38..97
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 93..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 289 AA; 31594 MW; 13D60DFC7A0FD16E CRC64;
MMSYLKQPPY TVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL DVLEALFAKT
RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ QNGGQNKVRP AKKKSSPARE
ASSESGASGQ FTPPSSTSVP AISTTTAPVS IWSPASISPL SDPLSTSSSC MQRSYPMTYT
QASGYSQGYA GSTSYFGGMD CGSYLTPMHH QLTGPGSTLS PMSSNAVTSH LNQSPASLPT
QGYGASGLGF NSTADCLDYK DQASSWKLNF NADCLDYKDQ TSSWKFQVL
//
