ID Q91997_CHICK Unreviewed; 377 AA.
AC Q91997;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase {ECO:0000313|EMBL:BAA07820.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:BAA07820.1};
RN [1] {ECO:0000313|EMBL:BAA07820.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adrenal gland {ECO:0000313|EMBL:BAA07820.1};
RX PubMed=7557440; DOI=10.1016/0378-1119(95)00278-E;
RA Nakabayashi O., Nomura O., Nishimori K., Mizuno S.;
RT "The cDNA cloning and transient expression of a chicken gene encoding a 3
RT beta-hydroxysteroid dehydrogenase/delta 5-->4 isomerase unique to major
RT steroidogenic tissues.";
RL Gene 162:261-265(1995).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR EMBL; D43762; BAA07819.1; -; mRNA.
DR EMBL; D43763; BAA07820.1; -; mRNA.
DR PIR; I50147; I50147.
DR RefSeq; NP_990449.1; NM_205118.1.
DR AlphaFoldDB; Q91997; -.
DR GeneID; 396015; -.
DR KEGG; gga:396015; -.
DR CTD; 3283; -.
DR VEuPathDB; HostDB:geneid_396015; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd09811; 3b-HSD_HSDB1_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 2: Evidence at transcript level;
KW Isomerase {ECO:0000313|EMBL:BAA07820.1};
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Transmembrane {ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 9..283
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 377 AA; 42882 MW; 22D9C5B8C7AD605C CRC64;
MSLAGVSCLV TGAGGFLGQR IVRLLLEEDE ALAEIRLLDK AFSREALWSF GKFQGKTEVK
ILEGDIRDVE FLHRACQGVS LVIHTASIID TLGLVEKQLL WEVNVTGTQM LLEACAHCNV
QHFIYTSTIE VAGPNCRGDP IFNGDEDTPY ESTSKFPYAQ SKRLAEECVL KADGQMLKDG
GVLVTCALRS MYIFGEGCPF LQGHLDKCLL NKNVYLRFSR KEALVNPVYV GNIAWAHVQA
AKALQVPQKA RHIRGQFYYI SDDTPHMSYA DLNYELTKEL GFGIEPWLPM PLTMLYYFSL
LLEIVSFMLR PFVRYIPSTN RHLVTLLNTP FTFSYRKAQK DFGYVPRYTW EEAKRYTSQW
IASIVPQRRE YLKSKKA
//
