ID Q91A48_HBV Unreviewed; 66 AA.
AC Q91A48;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
DE Flags: Fragment;
GN Name=C {ECO:0000256|RuleBase:RU361253};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AAL16421.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AAL16421.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11472634; DOI=10.1186/1471-2180-1-10;
RA De Castro L., Niel C., Gomes S.A.;
RT "Low frequency of mutations in the core promoter and precore regions of
RT hepatitis B virus in anti-HBe positive Brazilian carriers.";
RL BMC Microbiol. 1:10-10(2001).
RN [2] {ECO:0000313|EMBL:AAL16421.1}
RP NUCLEOTIDE SEQUENCE.
RA De Castro L., Niel C., Gomes S.A.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC acting as a T-cell tolerogen, by having an immunoregulatory effect
CC which prevents destruction of infected cells by cytotoxic T-cells.
CC {ECO:0000256|RuleBase:RU361253}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC {ECO:0000256|RuleBase:RU361253}.
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DR EMBL; AF390013; AAL16421.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW.
DR Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR InterPro; IPR002006; Hepatitis_core.
DR InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR Pfam; PF08290; Hep_core_N; 1.
DR Pfam; PF00906; Hepatitis_core; 1.
DR SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT DOMAIN 1..27
FT /note="Hepatitis B virus capsid N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08290"
FT NON_TER 66
FT /evidence="ECO:0000313|EMBL:AAL16421.1"
SQ SEQUENCE 66 AA; 7370 MW; 8EA6375595C43E96 CRC64;
MQLFHLCLII SCTCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
DTASAL
//
