ID Q91H15_HHV2 Unreviewed; 376 AA.
AC Q91H15;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Thymidine kinase tk {ECO:0000313|EMBL:AAK72384.1};
OS Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha2.
OX NCBI_TaxID=10310 {ECO:0000313|EMBL:AAK72384.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAK72384.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KN 53690 {ECO:0000313|EMBL:AAK72384.1};
RX PubMed=12367650; DOI=10.1016/S1386-6532(02)00005-7;
RA Chibo D., Mijch A., Doherty R., Birch C.;
RT "Novel mutations in the thymidine kinase and DNA polymerase genes of
RT acyclovir and foscarnet resistant herpes simplex viruses infecting an
RT immunocompromised patient.";
RL J. Clin. Virol. 25:165-170(2002).
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DR EMBL; AY038369; AAK72384.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAK72384.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAK72384.1}.
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 40495 MW; 3BDAD5B54F8FE1E5 CRC64;
MASHAGQQHA PAFGQAARVS GPTDGRAASR PSHRQGASEA RGDPELPTLL RVYIDGPHGV
GKTTTSAQLM EALGPRDNIV YVPEPMTYWQ VLGASETLTN IYNTQHRLDR GEISAGEAAV
VMTSAQITMS TPYAATDAVL APHIGGEAVG PQAPPPALTL VFDRHPIASL LCYPAARYLM
GSMTPQAVLA FVALMPPTAP GTNLVLGVLP EAEHADRLAR RQRPGERLDL AMLSAIRRVY
DLLANTVRYL QRGGRWREDW GRLTGVAAAT PRPDPEDGAG SLPRIEDTLF ALFRVPELLA
PNGDLYHIFA WVLDVLADRL LPMHLFVLDY DQSPVGCRDA LLRLTAGMIP TRVTTAGSIA
EIRDLARTFA REVGGV
//
