ID Q91QW5_9ENTO Unreviewed; 146 AA.
AC Q91QW5;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Human coxsackievirus A9B.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus B.
OX NCBI_TaxID=145389 {ECO:0000313|EMBL:CAC39006.1};
RN [1] {ECO:0000313|EMBL:CAC39006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P.B. {ECO:0000313|EMBL:CAC39006.1};
RX PubMed=12454151; DOI=10.1128/JCM.40.12.4554-4560.2002;
RA Manzara S., Muscillo M., La Rosa G., Marianelli C., Cattani P., Fadda G.;
RT "Molecular identification and typing of enteroviruses isolated from
RT clinical specimens.";
RL J. Clin. Microbiol. 40:4554-4560(2002).
RN [2] {ECO:0000313|EMBL:CAC39006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P.B. {ECO:0000313|EMBL:CAC39006.1};
RX PubMed=16458563; DOI=10.1016/j.ijid.2005.06.008;
RA Faustini A., Fano V., Muscillo M., Zaniratti S., La Rosa G., Tribuzi L.,
RA Perucci C.A.;
RT "An outbreak of aseptic meningitis due to echovirus 30 associated with
RT attending school and swimming in pools.";
RL Int. J. Infect. Dis. 10:291-297(2006).
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; AJ295200; CAC39006.1; -; Genomic_RNA.
DR GO; GO:0019028; C:viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 1.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561,
KW ECO:0000313|EMBL:CAC39006.1};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561, ECO:0000313|EMBL:CAC39006.1};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..143
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT NON_TER 146
FT /evidence="ECO:0000313|EMBL:CAC39006.1"
SQ SEQUENCE 146 AA; 15994 MW; E2590699B658288C CRC64;
MGAQVSTQKT GAHETSLSAA GNSIIHYTNI NYYKDAASNS ANRQDFTQDP SKFTEPVKDV
MIKSLPALNS PTVEECGYSD RVRSITLGNS TITTQECANV VVGYGRWPTY LRDDEATAED
QPTQPDVATC RFYTLDSIKW EKGSVG
//
