ID   Q91YF7_9RODE            Unreviewed;       385 AA.
AC   Q91YF7;
DT   01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT   01-DEC-2001, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE   Flags: Fragment;
GN   Name=vwf {ECO:0000313|EMBL:CAC37574.1};
OS   Macrotarsomys ingens (greater big-footed mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Nesomyidae; Nesomyinae; Macrotarsomys.
OX   NCBI_TaxID=61276 {ECO:0000313|EMBL:CAC37574.1};
RN   [1] {ECO:0000313|EMBL:CAC37574.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11606698;
RA   Michaux J., Reyes A., Catzeflis F.;
RT   "Evolutionary history of the most speciose mammals: molecular phylogeny of
RT   muroid rodents.";
RL   Mol. Biol. Evol. 18:2017-2031(2001).
CC   -!- SUBUNIT: Multimeric. Interacts with F8.
CC       {ECO:0000256|ARBA:ARBA00025858}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR   EMBL; AJ402705; CAC37574.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q91YF7; -.
DR   GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR   CDD; cd01450; vWFA_subfamily_ECM; 2.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR   InterPro; IPR032361; VWA_N2.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   Pfam; PF00092; VWA; 2.
DR   Pfam; PF16164; VWA_N2; 1.
DR   PRINTS; PR00453; VWFADOMAIN.
DR   SMART; SM00327; VWA; 2.
DR   SUPFAM; SSF53300; vWA-like; 2.
DR   PROSITE; PS50234; VWFA; 2.
PE   4: Predicted;
KW   Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT   DOMAIN          27..203
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          248..385
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CAC37574.1"
FT   NON_TER         385
FT                   /evidence="ECO:0000313|EMBL:CAC37574.1"
SQ   SEQUENCE   385 AA;  42814 MW;  5AC67AC7BBEE5973 CRC64;
     PVSSTTPYVE GTPEPPLHDF YCSKLLDLVF LLDGSSRLSE AEFEVLKTFV VGMMERLLIS
     QKRIRVAVVE YHDGSHAYIE LKARKRPSEL RRIASQVRYA GSQVASTSEV LKYTLFQIFG
     KVDRPEASRI ILLLTASQEP PRMARNLVRY VQGLKKKKVI VIPVGIGPHA SVKQIRLIEK
     QAPQNKAFLL SGVDELEQRR DEIINYLCDL APAAPAPTQP PRVAEVTIAP GIFGTSSPGP
     KRKSMVLDVV FVLEGSDEVG EANFNKSKEF LEEVIHRMDV GQDGIHITVL QYSYMVTVEY
     TFNEAQSKGD VLRHVREINY HGGNRTNTGQ ALQYLSEHSF SPSQGDRKQA PNLVYMVTGS
     PASDEIRRLP GDIQVVPIGV GPHAN
//