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Database: UniProt
Entry: Q91ZZ5
LinkDB: Q91ZZ5
Original site: Q91ZZ5 
ID   RXFP2_MOUSE             Reviewed;         737 AA.
AC   Q91ZZ5; Q0VB90;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-SEP-2014, entry version 116.
DE   RecName: Full=Relaxin receptor 2;
DE   AltName: Full=G-protein coupled receptor 106;
DE   AltName: Full=G-protein coupled receptor affecting testicular descent;
DE   AltName: Full=Leucine-rich repeat-containing G-protein coupled receptor 8;
DE   AltName: Full=Relaxin family peptide receptor 2;
GN   Name=Rxfp2; Synonyms=Gpr106, Great, Lgr8;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6;
RX   PubMed=11353515; DOI=10.1002/gene.1029;
RA   Overbeek P.A., Gorlov I.P., Sutherland R.W., Houston J.B.,
RA   Harrison W.R., Boettger-Tong H.L., Bishop C.E., Agoulnik A.I.;
RT   "A transgenic insertion causing cryptorchidism in mice.";
RL   Genesis 30:26-35(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for relaxin. The activity of this receptor is
CC       mediated by G proteins leading to stimulation of adenylate cyclase
CC       and an increase of cAMP. May also be a receptor for Leydig
CC       insulin-like peptide (INSL3) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in embryonic and adult gonads of
CC       males and females, as well in male gubernarculum. Expressed also
CC       in brain. Not detected in kidney, spleen and heart.
CC   -!- DISEASE: Note=Defects in Rxfp2 seems to be a cause of impaired
CC       testicular descent (known as cryptorchidism).
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC   -!- SIMILARITY: Contains 1 LDL-receptor class A domain.
CC   -!- SIMILARITY: Contains 10 LRR (leucine-rich) repeats.
CC   -!- CAUTION: By homology with the human sequence, it is uncertain
CC       whether Met-1 is the initiator.
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DR   EMBL; AF346501; AAL08943.1; -; mRNA.
DR   EMBL; AC077689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC120741; AAI20742.1; -; mRNA.
DR   CCDS; CCDS19886.1; -.
DR   RefSeq; NP_001276493.1; NM_001289564.1.
DR   RefSeq; NP_001276495.1; NM_001289566.1.
DR   RefSeq; NP_536716.2; NM_080468.2.
DR   RefSeq; XP_006504972.1; XM_006504909.1.
DR   UniGene; Mm.444643; -.
DR   ProteinModelPortal; Q91ZZ5; -.
DR   SMR; Q91ZZ5; 28-64, 102-689.
DR   GuidetoPHARMACOLOGY; 352; -.
DR   PhosphoSite; Q91ZZ5; -.
DR   PRIDE; Q91ZZ5; -.
DR   Ensembl; ENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368.
DR   GeneID; 140498; -.
DR   KEGG; mmu:140498; -.
DR   UCSC; uc009ato.1; mouse.
DR   CTD; 122042; -.
DR   MGI; MGI:2153463; Rxfp2.
DR   eggNOG; COG4886; -.
DR   GeneTree; ENSGT00730000110698; -.
DR   HOGENOM; HOG000049056; -.
DR   HOVERGEN; HBG026354; -.
DR   InParanoid; Q0VB90; -.
DR   KO; K04307; -.
DR   OMA; KILCCAD; -.
DR   OrthoDB; EOG77DJ5W; -.
DR   TreeFam; TF326185; -.
DR   Reactome; REACT_198713; Relaxin receptors.
DR   NextBio; 369832; -.
DR   PRO; PR:Q91ZZ5; -.
DR   ArrayExpress; Q91ZZ5; -.
DR   Bgee; Q91ZZ5; -.
DR   CleanEx; MM_RXFP2; -.
DR   Genevestigator; Q91ZZ5; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR   GO; GO:0016500; F:protein-hormone receptor activity; IMP:MGI.
DR   GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:MGI.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0008584; P:male gonad development; IMP:MGI.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0001556; P:oocyte maturation; IEA:Ensembl.
DR   GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Ensembl.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   Gene3D; 4.10.400.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR000372; LRR-contain_N.
DR   InterPro; IPR008112; Relaxin_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF13855; LRR_8; 2.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01739; RELAXINR.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00369; LRR_TYP; 2.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS51450; LRR; 10.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Leucine-rich repeat;
KW   Membrane; Receptor; Reference proteome; Repeat; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN         1    737       Relaxin receptor 2.
FT                                /FTId=PRO_0000069703.
FT   TOPO_DOM      1    399       Extracellular (Potential).
FT   TRANSMEM    400    420       Helical; Name=1; (Potential).
FT   TOPO_DOM    421    438       Cytoplasmic (Potential).
FT   TRANSMEM    439    459       Helical; Name=2; (Potential).
FT   TOPO_DOM    460    478       Extracellular (Potential).
FT   TRANSMEM    479    501       Helical; Name=3; (Potential).
FT   TOPO_DOM    502    520       Cytoplasmic (Potential).
FT   TRANSMEM    521    541       Helical; Name=4; (Potential).
FT   TOPO_DOM    542    575       Extracellular (Potential).
FT   TRANSMEM    576    596       Helical; Name=5; (Potential).
FT   TOPO_DOM    597    622       Cytoplasmic (Potential).
FT   TRANSMEM    623    643       Helical; Name=6; (Potential).
FT   TOPO_DOM    644    653       Extracellular (Potential).
FT   TRANSMEM    654    674       Helical; Name=7; (Potential).
FT   TOPO_DOM    675    737       Cytoplasmic (Potential).
FT   DOMAIN       27     64       LDL-receptor class A.
FT   REPEAT      121    142       LRR 1.
FT   REPEAT      145    166       LRR 2.
FT   REPEAT      169    190       LRR 3.
FT   REPEAT      193    214       LRR 4.
FT   REPEAT      217    238       LRR 5.
FT   REPEAT      241    262       LRR 6.
FT   REPEAT      265    286       LRR 7.
FT   REPEAT      289    310       LRR 8.
FT   REPEAT      313    334       LRR 9.
FT   REPEAT      337    358       LRR 10.
FT   CARBOHYD     37     37       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    121    121       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    257    257       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    318    318       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    350    350       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    361    361       N-linked (GlcNAc...) (Potential).
FT   DISULFID     28     41       By similarity.
FT   DISULFID     35     54       By similarity.
FT   DISULFID     48     63       By similarity.
FT   DISULFID    478    556       By similarity.
FT   CONFLICT    222    222       S -> P (in Ref. 1; AAL08943).
SQ   SEQUENCE   737 AA;  82934 MW;  AF60F63538061E49 CRC64;
     MWLLLHVILL TEVKDFALAD SSMVAPLCPK GYFPCGNLTK CLPRAFHCDG VDDCGNGADE
     DNCGDTSGWT TIFGTVHGNV NKVTLTQECF LSQYPQHCYC RENELECVKA DLKAVPKVSS
     NVTLLSLKKN KIHRLPVKVF SRYTELRKIY LQHNCITHIS RRAFLGLHNL QILYLSHNCI
     TSLRPGIFKD LHQLAWLILD DNPITRISQK SFMGLNSLFF LSMVGNRLEA LPETLCAQMP
     QLNWVDLANN GIKYITNSTF LTCDSLTVLF LPRNQIGFVP EKTFSSLKNL GELDLSSNMI
     TKLPVHLFSD LHLLQKLNLS SNPLLYVHKN QFGSLKQLQS LDLERIEIPN ISTGMFQPMK
     NLSHIYLKTF RYCSYVPHVR ICMPSTDGIS SSEDLLANGI LRVSVWVIAF ITCVGNFLVI
     AVRSLIKAEN TTHAMSIKIL CCADCLMGVY LFSVGVFDIK YRGQYQKYAL LWMESVPCRL
     LGFLATLSTE VSVLLLTFLT LEKFLVIVFP FSNLRLGKRQ TAVALASIWV VGFLIAAVPF
     TREDYFGNFY GKNGVCFPLH YDQAEDFGSR GYSLGIFLGV NLLAFLVIVI SYVTMFCSIH
     KTALQTAEVR SHIGKEVAVA NRFFFIVFSD AICWIPVFVV KILSLLQVEI PGTITSWIVV
     FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKPIFKV KKKSLSASIV WTDESSLKLG
     VLSKIALGDS IMKPVSP
//
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