ID RXFP2_MOUSE Reviewed; 737 AA.
AC Q91ZZ5; Q0VB90;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 01-MAY-2013, entry version 102.
DE RecName: Full=Relaxin receptor 2;
DE AltName: Full=G-protein coupled receptor 106;
DE AltName: Full=G-protein coupled receptor affecting testicular descent;
DE AltName: Full=Leucine-rich repeat-containing G-protein coupled receptor 8;
DE AltName: Full=Relaxin family peptide receptor 2;
GN Name=Rxfp2; Synonyms=Gpr106, Great, Lgr8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6;
RX PubMed=11353515; DOI=10.1002/gene.1029;
RA Overbeek P.A., Gorlov I.P., Sutherland R.W., Houston J.B.,
RA Harrison W.R., Boettger-Tong H.L., Bishop C.E., Agoulnik A.I.;
RT "A transgenic insertion causing cryptorchidism in mice.";
RL Genesis 30:26-35(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of
RT the mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for relaxin. The activity of this receptor is
CC mediated by G proteins leading to stimulation of adenylate cyclase
CC and an increase of cAMP. May also be a receptor for Leydig
CC insulin-like peptide (INSL3) (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic and adult gonads of
CC males and females, as well in male gubernarculum. Expressed also
CC in brain. Not detected in kidney, spleen and heart.
CC -!- DISEASE: Note=Defects in Rxfp2 seems to be a cause of impaired
CC testicular descent (known as cryptorchidism).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC -!- SIMILARITY: Contains 1 LDL-receptor class A domain.
CC -!- SIMILARITY: Contains 10 LRR (leucine-rich) repeats.
CC -!- CAUTION: By homology with the human sequence, it is uncertain
CC whether Met-1 is the initiator.
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DR EMBL; AF346501; AAL08943.1; -; mRNA.
DR EMBL; AC077689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC120741; AAI20742.1; -; mRNA.
DR IPI; IPI00131616; -.
DR RefSeq; NP_536716.2; NM_080468.2.
DR UniGene; Mm.444643; -.
DR ProteinModelPortal; Q91ZZ5; -.
DR SMR; Q91ZZ5; 28-64, 79-367, 407-689.
DR PhosphoSite; Q91ZZ5; -.
DR PRIDE; Q91ZZ5; -.
DR Ensembl; ENSMUST00000065745; ENSMUSP00000067897; ENSMUSG00000053368.
DR GeneID; 140498; -.
DR KEGG; mmu:140498; -.
DR CTD; 122042; -.
DR MGI; MGI:2153463; Rxfp2.
DR eggNOG; COG4886; -.
DR GeneTree; ENSGT00650000093266; -.
DR HOGENOM; HOG000049056; -.
DR HOVERGEN; HBG026354; -.
DR InParanoid; Q0VB90; -.
DR KO; K04307; -.
DR OMA; KILCCAD; -.
DR OrthoDB; EOG47M1XF; -.
DR NextBio; 369832; -.
DR ArrayExpress; Q91ZZ5; -.
DR Bgee; Q91ZZ5; -.
DR CleanEx; MM_RXFP2; -.
DR Genevestigator; Q91ZZ5; -.
DR GermOnline; ENSMUSG00000053368; Mus musculus.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017046; F:peptide hormone binding; IEA:Compara.
DR GO; GO:0016500; F:protein-hormone receptor activity; IMP:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IMP:MGI.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; IEA:Compara.
DR GO; GO:0008584; P:male gonad development; IMP:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
DR GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
DR GO; GO:0001556; P:oocyte maturation; IEA:Compara.
DR GO; GO:0030819; P:positive regulation of cAMP biosynthetic process; IEA:Compara.
DR Gene3D; 4.10.400.10; -; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR000372; LRR-contain_N.
DR InterPro; IPR008112; Relaxin_rcpt.
DR Pfam; PF00001; 7tm_1; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01739; RELAXINR.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF57424; LDL_rcpt_classA_cys-rich; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS51450; LRR; 10.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Leucine-rich repeat;
KW Membrane; Receptor; Reference proteome; Repeat; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1 737 Relaxin receptor 2.
FT /FTId=PRO_0000069703.
FT TOPO_DOM 1 399 Extracellular (Potential).
FT TRANSMEM 400 420 Helical; Name=1; (Potential).
FT TOPO_DOM 421 438 Cytoplasmic (Potential).
FT TRANSMEM 439 459 Helical; Name=2; (Potential).
FT TOPO_DOM 460 478 Extracellular (Potential).
FT TRANSMEM 479 501 Helical; Name=3; (Potential).
FT TOPO_DOM 502 520 Cytoplasmic (Potential).
FT TRANSMEM 521 541 Helical; Name=4; (Potential).
FT TOPO_DOM 542 575 Extracellular (Potential).
FT TRANSMEM 576 596 Helical; Name=5; (Potential).
FT TOPO_DOM 597 622 Cytoplasmic (Potential).
FT TRANSMEM 623 643 Helical; Name=6; (Potential).
FT TOPO_DOM 644 653 Extracellular (Potential).
FT TRANSMEM 654 674 Helical; Name=7; (Potential).
FT TOPO_DOM 675 737 Cytoplasmic (Potential).
FT DOMAIN 27 64 LDL-receptor class A.
FT REPEAT 121 142 LRR 1.
FT REPEAT 145 166 LRR 2.
FT REPEAT 169 190 LRR 3.
FT REPEAT 193 214 LRR 4.
FT REPEAT 217 238 LRR 5.
FT REPEAT 241 262 LRR 6.
FT REPEAT 265 286 LRR 7.
FT REPEAT 289 310 LRR 8.
FT REPEAT 313 334 LRR 9.
FT REPEAT 337 358 LRR 10.
FT CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 121 121 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 257 257 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 318 318 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 350 350 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 361 361 N-linked (GlcNAc...) (Potential).
FT DISULFID 28 41 By similarity.
FT DISULFID 35 54 By similarity.
FT DISULFID 48 63 By similarity.
FT DISULFID 478 556 By similarity.
FT CONFLICT 222 222 S -> P (in Ref. 1; AAL08943).
SQ SEQUENCE 737 AA; 82934 MW; AF60F63538061E49 CRC64;
MWLLLHVILL TEVKDFALAD SSMVAPLCPK GYFPCGNLTK CLPRAFHCDG VDDCGNGADE
DNCGDTSGWT TIFGTVHGNV NKVTLTQECF LSQYPQHCYC RENELECVKA DLKAVPKVSS
NVTLLSLKKN KIHRLPVKVF SRYTELRKIY LQHNCITHIS RRAFLGLHNL QILYLSHNCI
TSLRPGIFKD LHQLAWLILD DNPITRISQK SFMGLNSLFF LSMVGNRLEA LPETLCAQMP
QLNWVDLANN GIKYITNSTF LTCDSLTVLF LPRNQIGFVP EKTFSSLKNL GELDLSSNMI
TKLPVHLFSD LHLLQKLNLS SNPLLYVHKN QFGSLKQLQS LDLERIEIPN ISTGMFQPMK
NLSHIYLKTF RYCSYVPHVR ICMPSTDGIS SSEDLLANGI LRVSVWVIAF ITCVGNFLVI
AVRSLIKAEN TTHAMSIKIL CCADCLMGVY LFSVGVFDIK YRGQYQKYAL LWMESVPCRL
LGFLATLSTE VSVLLLTFLT LEKFLVIVFP FSNLRLGKRQ TAVALASIWV VGFLIAAVPF
TREDYFGNFY GKNGVCFPLH YDQAEDFGSR GYSLGIFLGV NLLAFLVIVI SYVTMFCSIH
KTALQTAEVR SHIGKEVAVA NRFFFIVFSD AICWIPVFVV KILSLLQVEI PGTITSWIVV
FFLPVNSALN PILYTLTTSF FKDKLKQLLH KHRRKPIFKV KKKSLSASIV WTDESSLKLG
VLSKIALGDS IMKPVSP
//
