ID DQX1_MOUSE Reviewed; 718 AA.
AC Q924H9; Q80ZJ5;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 01-MAY-2013, entry version 81.
DE RecName: Full=ATP-dependent RNA helicase DQX1;
DE EC=3.6.4.12;
DE AltName: Full=DEAQ box polypeptide 1;
GN Name=Dqx1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=11353393; DOI=10.1007/s003350020032;
RA Ji W., Chen F., Do T., Do A., Roe B.A., Meisler M.H.;
RT "DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box:
RT expression pattern and genomic sequence comparison of the human and
RT mouse genes.";
RL Mamm. Genome 12:456-461(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6, and FVB/N; TISSUE=Colon, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q924H9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q924H9-2; Sequence=VSP_024473;
CC -!- TISSUE SPECIFICITY: Ubiquitous.
CC -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC -!- SIMILARITY: Contains 1 helicase C-terminal domain.
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DR EMBL; AF318278; AAK62817.1; -; mRNA.
DR EMBL; BC048936; AAH48936.1; -; mRNA.
DR EMBL; BC075680; AAH75680.1; -; mRNA.
DR IPI; IPI00125675; -.
DR IPI; IPI00844713; -.
DR RefSeq; NP_291084.1; NM_033606.3.
DR UniGene; Mm.140332; -.
DR ProteinModelPortal; Q924H9; -.
DR SMR; Q924H9; 20-693.
DR PhosphoSite; Q924H9; -.
DR PRIDE; Q924H9; -.
DR Ensembl; ENSMUST00000077502; ENSMUSP00000076708; ENSMUSG00000009145.
DR GeneID; 93838; -.
DR KEGG; mmu:93838; -.
DR UCSC; uc009cmc.1; mouse.
DR UCSC; uc009cmd.1; mouse.
DR CTD; 165545; -.
DR MGI; MGI:2136388; Dqx1.
DR eggNOG; COG1643; -.
DR GeneTree; ENSGT00650000093246; -.
DR HOGENOM; HOG000175261; -.
DR HOVERGEN; HBG039428; -.
DR InParanoid; Q924H9; -.
DR KO; K14433; -.
DR OMA; CGQAVQA; -.
DR OrthoDB; EOG4548Z3; -.
DR NextBio; 351693; -.
DR Bgee; Q924H9; -.
DR CleanEx; MM_DQX1; -.
DR Genevestigator; Q924H9; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATPase activity; ISA:MGI.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR InterPro; IPR011709; DUF1605.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR Pfam; PF04408; HA2; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; ATP-binding; Complete proteome; Helicase;
KW Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT CHAIN 1 718 ATP-dependent RNA helicase DQX1.
FT /FTId=PRO_0000284378.
FT DOMAIN 54 222 Helicase ATP-binding.
FT DOMAIN 245 447 Helicase C-terminal.
FT NP_BIND 67 74 ATP (By similarity).
FT MOTIF 167 170 DEAQ box.
FT COMPBIAS 197 200 Poly-Val.
FT VAR_SEQ 1 417 Missing (in isoform 2).
FT /FTId=VSP_024473.
SQ SEQUENCE 718 AA; 78799 MW; 4285388B61D69EB4 CRC64;
MASGLAEESE LSPGESELAV NPFDGLPFSS CYYELLEQRR ALPIWAARFL FLEHLESSPT
GVVLVSGDPG SGKSTQIPQW CAEFALARGF QTGQVTVTQP YPLAAMSLAS RVADEMDLTL
GHEIGYSIPQ EDCTGPNTML RFCWDRLFLQ EVASTRGPGA WSVLILDEAQ ERSVASDLLQ
GLLRDTRLRN LPGDPRVVVV TDPALEPKFQ AFWGNSPIVR VPREPGGDPT LAYKDTVPTD
LVEAACQAVL ELCQQEEAPG DVLVYLPSEE EISLCCESLS GEMGTLAVPG PPPRVLPLHP
GCAQAIQTVY EDTDVSVRKI VVTHWLADFS FSLPSIQHVI DSGLELRSVY NPRIRAESQV
LRPISKCQAE ARLLRAKGFP PGSCLRLYSK STLELEAPPL PHPKVCEENL SSLVLLLMRK
QIAEPGECHF LDRPAPEALM RALEDLDYLA ALNDDGELSD LGVILSEFPL PPELAKALLA
SCEFNCVDEM LTLAAMLTAA PGFTRPPLSA GEAALRRALE HADGDHSSLI QVYEAFVQSG
ADEAWCQARG LNWESLCQAR KLRAELVELM QRIELPLSQP AFGSEQNRRD LQKALLSGYF
LKVARDTDGT GNYLLLTHKH VAQLSPYCSY RNRRTPAQPP TWVLYHSFSI SKDNCLCIVS
EIQPEMLVEL APPYFLSNLP PSESRDLLNQ LREGTAEPPA AATETSSPQE YGDGCVLQ
//
