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Database: UniProt
Entry: Q924H9
LinkDB: Q924H9
Original site: Q924H9 
ID   DQX1_MOUSE              Reviewed;         718 AA.
AC   Q924H9; Q80ZJ5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   01-OCT-2014, entry version 92.
DE   RecName: Full=ATP-dependent RNA helicase DQX1;
DE            EC=3.6.4.12;
DE   AltName: Full=DEAQ box polypeptide 1;
GN   Name=Dqx1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=11353393; DOI=10.1007/s003350020032;
RA   Ji W., Chen F., Do T., Do A., Roe B.A., Meisler M.H.;
RT   "DQX1, an RNA-dependent ATPase homolog with a novel DEAQ box:
RT   expression pattern and genomic sequence comparison of the human and
RT   mouse genes.";
RL   Mamm. Genome 12:456-461(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6, and FVB/N; TISSUE=Colon, and Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q924H9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q924H9-2; Sequence=VSP_024473;
CC   -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11353393}.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00541}.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00542}.
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DR   EMBL; AF318278; AAK62817.1; -; mRNA.
DR   EMBL; BC048936; AAH48936.1; -; mRNA.
DR   EMBL; BC075680; AAH75680.1; -; mRNA.
DR   CCDS; CCDS20268.1; -. [Q924H9-1]
DR   RefSeq; NP_291084.1; NM_033606.3. [Q924H9-1]
DR   RefSeq; XP_006506870.1; XM_006506807.1. [Q924H9-1]
DR   RefSeq; XP_006506871.1; XM_006506808.1. [Q924H9-1]
DR   RefSeq; XP_006506872.1; XM_006506809.1. [Q924H9-1]
DR   UniGene; Mm.140332; -.
DR   ProteinModelPortal; Q924H9; -.
DR   SMR; Q924H9; 20-693.
DR   PhosphoSite; Q924H9; -.
DR   MaxQB; Q924H9; -.
DR   PRIDE; Q924H9; -.
DR   Ensembl; ENSMUST00000077502; ENSMUSP00000076708; ENSMUSG00000009145. [Q924H9-1]
DR   GeneID; 93838; -.
DR   KEGG; mmu:93838; -.
DR   UCSC; uc009cmc.1; mouse. [Q924H9-1]
DR   UCSC; uc009cmd.1; mouse. [Q924H9-2]
DR   CTD; 165545; -.
DR   MGI; MGI:2136388; Dqx1.
DR   eggNOG; COG1643; -.
DR   GeneTree; ENSGT00750000117467; -.
DR   HOGENOM; HOG000175261; -.
DR   HOVERGEN; HBG039428; -.
DR   InParanoid; Q924H9; -.
DR   KO; K14433; -.
DR   OMA; CGQAVQA; -.
DR   OrthoDB; EOG715Q3J; -.
DR   PhylomeDB; Q924H9; -.
DR   TreeFam; TF105735; -.
DR   NextBio; 351693; -.
DR   PRO; PR:Q924H9; -.
DR   Bgee; Q924H9; -.
DR   CleanEx; MM_DQX1; -.
DR   Genevestigator; Q924H9; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATPase activity; ISA:MGI.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006200; P:ATP catabolic process; ISA:GOC.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011709; DUF1605.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF04408; HA2; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Complete proteome; Helicase;
KW   Hydrolase; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1    718       ATP-dependent RNA helicase DQX1.
FT                                /FTId=PRO_0000284378.
FT   DOMAIN       54    222       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      245    447       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      67     74       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       167    170       DEAQ box.
FT   COMPBIAS    197    200       Poly-Val.
FT   VAR_SEQ       1    417       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_024473.
SQ   SEQUENCE   718 AA;  78799 MW;  4285388B61D69EB4 CRC64;
     MASGLAEESE LSPGESELAV NPFDGLPFSS CYYELLEQRR ALPIWAARFL FLEHLESSPT
     GVVLVSGDPG SGKSTQIPQW CAEFALARGF QTGQVTVTQP YPLAAMSLAS RVADEMDLTL
     GHEIGYSIPQ EDCTGPNTML RFCWDRLFLQ EVASTRGPGA WSVLILDEAQ ERSVASDLLQ
     GLLRDTRLRN LPGDPRVVVV TDPALEPKFQ AFWGNSPIVR VPREPGGDPT LAYKDTVPTD
     LVEAACQAVL ELCQQEEAPG DVLVYLPSEE EISLCCESLS GEMGTLAVPG PPPRVLPLHP
     GCAQAIQTVY EDTDVSVRKI VVTHWLADFS FSLPSIQHVI DSGLELRSVY NPRIRAESQV
     LRPISKCQAE ARLLRAKGFP PGSCLRLYSK STLELEAPPL PHPKVCEENL SSLVLLLMRK
     QIAEPGECHF LDRPAPEALM RALEDLDYLA ALNDDGELSD LGVILSEFPL PPELAKALLA
     SCEFNCVDEM LTLAAMLTAA PGFTRPPLSA GEAALRRALE HADGDHSSLI QVYEAFVQSG
     ADEAWCQARG LNWESLCQAR KLRAELVELM QRIELPLSQP AFGSEQNRRD LQKALLSGYF
     LKVARDTDGT GNYLLLTHKH VAQLSPYCSY RNRRTPAQPP TWVLYHSFSI SKDNCLCIVS
     EIQPEMLVEL APPYFLSNLP PSESRDLLNQ LREGTAEPPA AATETSSPQE YGDGCVLQ
//
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