ID IL24_MOUSE Reviewed; 181 AA.
AC Q925S4; Q925J3;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 01-MAY-2013, entry version 83.
DE RecName: Full=Interleukin-24;
DE Short=IL-24;
DE AltName: Full=IL-4-induced secreted protein;
DE AltName: Full=Melanoma differentiation-associated gene 7 protein;
DE Short=MDA-7;
DE AltName: Full=Th2-specific cytokine FISP;
DE Flags: Precursor;
GN Name=Il24; Synonyms=Mda7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/SvJ;
RA Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.;
RT "Genomic structure, chromosomal localization and expression of
RT melanoma differentiation associated gene-7 (mda-7): potential
RT relationship with cellular senescence.";
RL Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=BALB/c;
RX PubMed=11342597;
RA Schaefer G., Venkataraman C., Schindler U.;
RT "FISP (IL-4-induced secreted protein), a novel cytokine-like molecule
RT secreted by Th2 cells.";
RL J. Immunol. 166:5859-5863(2001).
CC -!- FUNCTION: Has antiproliferative properties on melanoma cells and
CC may contribute to terminal cell differentiation (By similarity).
CC -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC -!- TISSUE SPECIFICITY: Selectively expressed by Th2 cells.
CC -!- INDUCTION: By IL-4.
CC -!- SIMILARITY: Belongs to the IL-10 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK52470.1; Type=Erroneous initiation;
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DR EMBL; AF235006; AAK52590.1; -; mRNA.
DR EMBL; AF333251; AAK52470.1; ALT_INIT; mRNA.
DR IPI; IPI00126941; -.
DR RefSeq; NP_444325.2; NM_053095.2.
DR UniGene; Mm.196691; -.
DR ProteinModelPortal; Q925S4; -.
DR SMR; Q925S4; 32-177.
DR PhosphoSite; Q925S4; -.
DR PRIDE; Q925S4; -.
DR Ensembl; ENSMUST00000121040; ENSMUSP00000113064; ENSMUSG00000026420.
DR GeneID; 93672; -.
DR KEGG; mmu:93672; -.
DR UCSC; uc007cmo.1; mouse.
DR CTD; 11009; -.
DR MGI; MGI:2135548; Il24.
DR eggNOG; NOG45557; -.
DR GeneTree; ENSGT00410000025637; -.
DR HOGENOM; HOG000113033; -.
DR HOVERGEN; HBG098494; -.
DR InParanoid; Q925S4; -.
DR KO; K05444; -.
DR OrthoDB; EOG4ZPDW8; -.
DR NextBio; 351374; -.
DR ArrayExpress; Q925S4; -.
DR Bgee; Q925S4; -.
DR CleanEx; MM_IL24; -.
DR Genevestigator; Q925S4; -.
DR GermOnline; ENSMUSG00000026420; Mus musculus.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR GO; GO:0005576; C:extracellular region; IDA:MGI.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; ISA:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0071353; P:cellular response to interleukin-4; IEA:Compara.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Compara.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Compara.
DR GO; GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
DR GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
DR GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Compara.
DR GO; GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Compara.
DR GO; GO:0042060; P:wound healing; IEA:Compara.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR020443; Interleukin-10/19/20/24.
DR InterPro; IPR020423; Interleukin-10_CS.
DR InterPro; IPR020444; Interleukin-24.
DR PANTHER; PTHR11585; PTHR11585; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01937; INTRLEUKIN24.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Complete proteome; Cytokine; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 26 Potential.
FT CHAIN 27 181 Interleukin-24.
FT /FTId=PRO_0000042240.
FT CARBOHYD 74 74 N-linked (GlcNAc...) (Potential).
FT CONFLICT 31 31 S -> F (in Ref. 2; AAK52470).
SQ SEQUENCE 181 AA; 20812 MW; 05CA43872D53D555 CRC64;
MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD
ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI
VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH
L
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