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Database: UniProt
Entry: Q925S4
LinkDB: Q925S4
Original site: Q925S4 
ID   IL24_MOUSE              Reviewed;         181 AA.
AC   Q925S4; Q925J3;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-APR-2014, entry version 92.
DE   RecName: Full=Interleukin-24;
DE            Short=IL-24;
DE   AltName: Full=IL-4-induced secreted protein;
DE   AltName: Full=Melanoma differentiation-associated gene 7 protein;
DE            Short=MDA-7;
DE   AltName: Full=Th2-specific cytokine FISP;
DE   Flags: Precursor;
GN   Name=Il24; Synonyms=Mda7;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=129/SvJ;
RA   Madireddi M.T., Lin J., Su Z.-Z., Shay J.W., Huberman E., Fisher P.B.;
RT   "Genomic structure, chromosomal localization and expression of
RT   melanoma differentiation associated gene-7 (mda-7): potential
RT   relationship with cellular senescence.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=BALB/c;
RX   PubMed=11342597;
RA   Schaefer G., Venkataraman C., Schindler U.;
RT   "FISP (IL-4-induced secreted protein), a novel cytokine-like molecule
RT   secreted by Th2 cells.";
RL   J. Immunol. 166:5859-5863(2001).
CC   -!- FUNCTION: Has antiproliferative properties on melanoma cells and
CC       may contribute to terminal cell differentiation (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted (Potential).
CC   -!- TISSUE SPECIFICITY: Selectively expressed by Th2 cells.
CC   -!- INDUCTION: By IL-4.
CC   -!- PTM: Ubiquitination at Lys-97 promotes proteasomal degradation (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the IL-10 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK52470.1; Type=Erroneous initiation;
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DR   EMBL; AF235006; AAK52590.1; -; mRNA.
DR   EMBL; AF333251; AAK52470.1; ALT_INIT; mRNA.
DR   RefSeq; NP_444325.2; NM_053095.2.
DR   UniGene; Mm.196691; -.
DR   ProteinModelPortal; Q925S4; -.
DR   SMR; Q925S4; 32-177.
DR   PhosphoSite; Q925S4; -.
DR   PRIDE; Q925S4; -.
DR   Ensembl; ENSMUST00000121040; ENSMUSP00000113064; ENSMUSG00000026420.
DR   GeneID; 93672; -.
DR   KEGG; mmu:93672; -.
DR   CTD; 11009; -.
DR   MGI; MGI:2135548; Il24.
DR   eggNOG; NOG45557; -.
DR   GeneTree; ENSGT00410000025637; -.
DR   HOGENOM; HOG000113033; -.
DR   HOVERGEN; HBG098494; -.
DR   InParanoid; Q925S4; -.
DR   KO; K05444; -.
DR   OrthoDB; EOG7060SK; -.
DR   PhylomeDB; Q925S4; -.
DR   TreeFam; TF333253; -.
DR   NextBio; 351374; -.
DR   PRO; PR:Q925S4; -.
DR   Bgee; Q925S4; -.
DR   CleanEx; MM_IL24; -.
DR   Genevestigator; Q925S4; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0005576; C:extracellular region; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; ISA:MGI.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0071353; P:cellular response to interleukin-4; IEA:Ensembl.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IGI:MGI.
DR   GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.
DR   GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IGI:MGI.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; IDA:MGI.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IEA:Ensembl.
DR   GO; GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.
DR   GO; GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IEA:Ensembl.
DR   GO; GO:0033136; P:serine phosphorylation of STAT3 protein; IEA:Ensembl.
DR   GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR020443; IL-10/19/20/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   InterPro; IPR020444; IL-24.
DR   PANTHER; PTHR11585; PTHR11585; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01937; INTRLEUKIN24.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Complete proteome; Cytokine; Glycoprotein; Isopeptide bond;
KW   Reference proteome; Secreted; Signal; Ubl conjugation.
FT   SIGNAL        1     26       Potential.
FT   CHAIN        27    181       Interleukin-24.
FT                                /FTId=PRO_0000042240.
FT   CARBOHYD     74     74       N-linked (GlcNAc...) (Potential).
FT   CROSSLNK     97     97       Glycyl lysine isopeptide (Lys-Gly)
FT                                (interchain with G-Cter in ubiquitin) (By
FT                                similarity).
FT   CONFLICT     31     31       S -> F (in Ref. 2; AAK52470).
SQ   SEQUENCE   181 AA;  20812 MW;  05CA43872D53D555 CRC64;
     MSWGLQILPC LSLILLLWNQ VPGLEGQEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD
     ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI
     VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH
     L
//
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