ID GLPK_LISIN Reviewed; 497 AA.
AC Q92BH6;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 01-MAY-2013, entry version 69.
DE RecName: Full=Glycerol kinase;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase;
DE AltName: Full=Glycerokinase;
DE Short=GK;
GN Name=glpK; OrderedLocusNames=lin1573;
OS Listeria innocua serovar 6a (strain CLIP 11262).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=272626;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIP 11262;
RX PubMed=11679669; DOI=10.1126/science.1063447;
RA Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A.,
RA Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T.,
RA Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P.,
RA Domann E., Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O.,
RA Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P.,
RA Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D.,
RA Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G.,
RA Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H.,
RA Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R.,
RA Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A.,
RA Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT "Comparative genomics of Listeria species.";
RL Science 294:849-852(2001).
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
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DR EMBL; AL596169; CAC96804.1; -; Genomic_DNA.
DR PIR; AD1629; AD1629.
DR RefSeq; NP_470909.1; NC_003212.1.
DR ProteinModelPortal; Q92BH6; -.
DR SMR; Q92BH6; 5-490.
DR STRING; 272626.lin1573; -.
DR EnsemblBacteria; CAC96804; CAC96804; CAC96804.
DR GeneID; 1130190; -.
DR KEGG; lin:lin1573; -.
DR PATRIC; 20299883; VBILisInn102668_1608.
DR GenoList; LIN1573; -.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; ALYGQLC; -.
DR ProtClustDB; PRK00047; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; FALSE_NEG.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Transferase.
FT CHAIN 1 497 Glycerol kinase.
FT /FTId=PRO_0000059463.
FT NP_BIND 411 415 ATP (By similarity).
FT BINDING 13 13 Substrate (By similarity).
FT BINDING 17 17 ATP (By similarity).
FT BINDING 83 83 Substrate (By similarity).
FT BINDING 135 135 Substrate (By similarity).
FT BINDING 245 245 Substrate (By similarity).
FT BINDING 267 267 ATP (By similarity).
FT BINDING 310 310 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 497 AA; 55436 MW; D4126042AD2F6F74 CRC64;
MEKKYILALD QGTTSSRAMI IDEEGEVIGV AQEEFDQIFP KPGWVEHSAN EIWASILAVI
AGVLLKTNIS SKEIAGIGIT NQRETTVIWD KESGNPIYNA IVWQSRQTED ICKQLRKDGY
EDTIRSKTGL LIDPYFAGTK ARWILDHVDG AQERAEKGEL LFGTIDTWLV WKLTGGRAHI
TDYSNASRTL LYNIYDLEWD DELLKMLNIP RAMLPEVRPS SEVYADTVPY HFFGEEVPVA
GIAGDQQAAL FGQGCFEKGM AKNTYGTGCF LLMNTGEKAV RSENGLLTTL AWGLDGKVEY
ALEGSIFVAG SAIQWLRDGL RMVRQSSDSE NYASRIESSD GVYVVPAFVG LGAPYWDSDV
RGAVFGLTRG TEKEQFIRAT LESLAYQTRD VLYAMEQDSG ISLKTLRVDG GASANNFLMQ
FQSDILGVPV ERPENKETTV LGAAFLAGLA VGVWKDKNEI KKHWKLDKRF EVEMKDDQRE
DLYEGWHKAV KAAQAFK
//
