ID ACCA_RHIME Reviewed; 317 AA.
AC Q92ME2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 01-MAY-2013, entry version 67.
DE RecName: Full=Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha;
DE Short=ACCase subunit alpha;
DE Short=Acetyl-CoA carboxylase carboxyltransferase subunit alpha;
DE EC=6.4.1.2;
GN Name=accA; OrderedLocusNames=R02682; ORFNames=SMc00690;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D.,
RA Pohl T., Portetelle D., Puehler A., Purnelle B., Ramsperger U.,
RA Renard C., Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont
RT Sinorhizobium meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F.,
RA Gloux S., Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M.,
RA Hernandez-Lucas I., Hong A., Huizar L., Hyman R.W., Jones T., Kahn D.,
RA Kahn M.L., Kalman S., Keating D.H., Kiss E., Komp C., Lelaure V.,
RA Masuy D., Palm C., Peck M.C., Pohl T.M., Portetelle D., Purnelle B.,
RA Ramsperger U., Surzycki R., Thebault P., Vandenbol M.,
RA Vorhoelter F.J., Weidner S., Wells D.H., Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Component of the acetyl coenzyme A carboxylase (ACC)
CC complex. First, biotin carboxylase catalyzes the carboxylation of
CC biotin on its carrier protein (BCCP) and then the CO(2) group is
CC transferred by the carboxyltransferase to acetyl-CoA to form
CC malonyl-CoA (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + acetyl-CoA + HCO(3)(-) = ADP + phosphate
CC + malonyl-CoA.
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA
CC from acetyl-CoA: step 1/1.
CC -!- SUBUNIT: Acetyl-CoA carboxylase is a heterohexamer composed of
CC biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC)
CC and two subunits each of ACCase subunit alpha (AccA) and ACCase
CC subunit beta (AccD) (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the AccA family.
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DR EMBL; AL591688; CAC47261.1; -; Genomic_DNA.
DR RefSeq; NP_386788.1; NC_003047.1.
DR ProteinModelPortal; Q92ME2; -.
DR STRING; 266834.SMc00690; -.
DR EnsemblBacteria; CAC47261; CAC47261; SMc00690.
DR GeneID; 1234357; -.
DR KEGG; sme:SMc00690; -.
DR PATRIC; 23634905; VBISinMel96828_4184.
DR eggNOG; COG0825; -.
DR HOGENOM; HOG000273832; -.
DR KO; K01962; -.
DR OMA; QLTKDIY; -.
DR ProtClustDB; PRK05724; -.
DR BioCyc; SMEL266834:GJF6-2748-MONOMER; -.
DR UniPathway; UPA00655; UER00711.
DR GO; GO:0009317; C:acetyl-CoA carboxylase complex; IEA:InterPro.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
DR GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_00823; AcetylCoA_CT_alpha; 1; -.
DR InterPro; IPR001095; Acetyl_CoA_COase_a_su.
DR InterPro; IPR011763; COA_CT_C.
DR PANTHER; PTHR22855:SF3; PTHR22855:SF3; 1.
DR Pfam; PF03255; ACCA; 1.
DR PRINTS; PR01069; ACCCTRFRASEA.
DR TIGRFAMs; TIGR00513; accA; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Cytoplasm; Fatty acid biosynthesis;
KW Fatty acid metabolism; Ligase; Lipid biosynthesis; Lipid metabolism;
KW Nucleotide-binding.
FT CHAIN 1 317 Acetyl-coenzyme A carboxylase carboxyl
FT transferase subunit alpha.
FT /FTId=PRO_0000223816.
SQ SEQUENCE 317 AA; 34680 MW; 000BCE9AB92DECC5 CRC64;
MHNYLDFEKP ISDLEGKILE LKKLASEDES VNTSDEIARL EGRVRDAMVE IYSKLSPWQK
TQVARHPSRP HFLDYASRLF TEFTPLAGDR NFANDDAIQA GLARFHGTPV AVIGQEKGND
TKSRIKHNFG SPRPEGYRKA TRIMEMADRF GLPLITLVDT AGAYPGVNAE ERGQAEAIAR
STEMCLNVKV PIVTVVIGEG GSGGAIAIAT GNRVYMLEHA IYSVISPEGA ASILWRDSTR
AKEAASNMKI TAEDLKSLGV IDGIIPEPVG GAHRDPDAVI SRTETVIGDA LKELSARNGD
ELRADRRQKY LNIGRNL
//
