ID Q93RW9_STRCO Unreviewed; 583 AA.
AC Q93RW9;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE SubName: Full=Bifunctional protein (CbiGH) {ECO:0000313|EMBL:CAC38792.1};
GN OrderedLocusNames=SCO1857 {ECO:0000313|EMBL:CAC38792.1};
GN ORFNames=SCI39.04 {ECO:0000313|EMBL:CAC38792.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC38792.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC38792.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL939110; CAC38792.1; -; Genomic_DNA.
DR RefSeq; NP_626124.1; NC_003888.3.
DR AlphaFoldDB; Q93RW9; -.
DR STRING; 100226.gene:17759454; -.
DR PaxDb; 100226-SCO1857; -.
DR PATRIC; fig|100226.15.peg.1881; -.
DR eggNOG; COG1010; Bacteria.
DR eggNOG; COG2073; Bacteria.
DR HOGENOM; CLU_009721_2_0_11; -.
DR InParanoid; Q93RW9; -.
DR OrthoDB; 9804789at2; -.
DR PhylomeDB; Q93RW9; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR Gene3D; 3.40.50.11220; -; 1.
DR Gene3D; 3.30.420.180; CobE/GbiG C-terminal domain; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR021744; CbiG_N.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR002750; CobE/GbiG_C.
DR InterPro; IPR036518; CobE/GbiG_C_sf.
DR InterPro; IPR038029; GbiG_N_sf.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF01890; CbiG_C; 1.
DR Pfam; PF11760; CbiG_N; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF159672; CbiG N-terminal domain-like; 1.
DR SUPFAM; SSF159664; CobE/GbiG C-terminal domain-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 9..89
FT /note="Cobalamin synthesis G N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11760"
FT DOMAIN 164..282
FT /note="CobE/GbiG C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01890"
FT DOMAIN 290..495
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT REGION 523..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 59364 MW; 7335CAC4AF50C6AF CRC64;
MYDGPVGDAV RAAFAECERL VCFLATGAVV RLVAPLLDDK RTDPGVVCVD EGGRFAVSLV
GGHGGGANEL ARAVGEVLGA EPVVTTATDA VGLAGLDTLG MPVEGDVAGV SRALLDGEPV
ALRAEVAWPL PPLPVAAEGA YGIRVTDRAV EPAAGEVVLR PPSLVVGVGA SRGAPVDEVL
GLVEAALREA GLSAASVAEL ATVDAKAGEP GIVGAAGRLG VPLVTHPADE LAGVEVPNPS
DAPLAAVGTP SVAEAAALVR GGELLVPKRK SAAVPAMATC AVVRRPGRGR LAVVGLGPGA
RDLVTPRARA ELRRASVLVG LDQYVDQIRD LLRPGTRVLE SGLGAEEERA RTAVEEARLG
HAVALIGSGD AGVYAMASPA LAEASDDIDV VGVPGVTAAL AAGAVLGAPL GHDHVSISLS
DLHTPWEVIE RRVRAAAEAD LVVTFYNPRS RGRDWQLPKA LAILAEHREP TTPVGVVRNA
SRADESSRLC TLAALDPATV DMMTVVTVGN TATREIAGRM VTPRGYRWQT RETAPPAERP
GSSPTAEVSA EPDVPDASAE PDVPAAPDVS AARDVSATPE ETL
//
