ID GPX3_CAEEL Reviewed; 224 AA.
AC Q95003;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 01-MAY-2013, entry version 87.
DE RecName: Full=Glutathione peroxidase;
DE EC=1.11.1.9;
DE Flags: Precursor;
GN ORFNames=C11E4.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for
RT investigating biology.";
RL Science 282:2012-2018(1998).
CC -!- CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione
CC disulfide + 2 H(2)O.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space (By
CC similarity).
CC -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR EMBL; Z81015; CAB02655.1; -; Genomic_DNA.
DR PIR; T19190; T19190.
DR RefSeq; NP_509616.1; NM_077215.4.
DR ProteinModelPortal; Q95003; -.
DR SMR; Q95003; 39-220.
DR STRING; 6239.C11E4.2; -.
DR PeroxiBase; 3748; CelGPx03.
DR PaxDb; Q95003; -.
DR EnsemblMetazoa; C11E4.2; C11E4.2; C11E4.2.
DR GeneID; 182513; -.
DR KEGG; cel:CELE_C11E4.2; -.
DR UCSC; C11E4.2; c. elegans.
DR CTD; 182513; -.
DR WormBase; C11E4.2; CE08102; WBGene00007517; -.
DR eggNOG; COG0386; -.
DR GeneTree; ENSGT00550000074312; -.
DR HOGENOM; HOG000277055; -.
DR InParanoid; Q95003; -.
DR KO; K00432; -.
DR OMA; IYDYDAF; -.
DR NextBio; 917856; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0004602; F:glutathione peroxidase activity; IEA:EC.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR Gene3D; 3.40.30.10; -; 1.
DR InterPro; IPR000889; Glutathione_peroxidase.
DR InterPro; IPR012336; Thioredoxin-like_fold.
DR PANTHER; PTHR11592; PTHR11592; 1.
DR Pfam; PF00255; GSHPx; 1.
DR PIRSF; PIRSF000303; Glutathion_perox; 1.
DR PRINTS; PR01011; GLUTPROXDASE.
DR SUPFAM; SSF52833; Thiordxn-like_fd; 1.
DR PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE 3: Inferred from homology;
KW Complete proteome; Glycoprotein; Oxidoreductase; Peroxidase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 224 Glutathione peroxidase.
FT /FTId=PRO_0000013090.
FT ACT_SITE 73 73 By similarity.
FT CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
SQ SEQUENCE 224 AA; 25556 MW; F02D055246EDE2F1 CRC64;
MAPGSVLSLA VALATIIGIS CTATVDETMR WKECLNTNQS IFDFQIETLQ GEYTDLSQYR
GKVILLVNVA TFCAYTQQYT DFNPMLEKYQ AQGLTLVAFP CNQFYLQEPA ENHELMNGLT
YVRPGNGWTP HQELHIYGKI DVNGDNHHPL YEFVKESCPQ TVDKIGKTDE LMYNPVRPSD
ITWNFEKFLI DRNGQPRFRF HPTAWSHGDV VTPFIEQLLA EPAN
//
