ID Q95WW5_PAPCA Unreviewed; 500 AA.
AC Q95WW5;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=unspecific monooxygenase {ECO:0000256|ARBA:ARBA00012109};
DE EC=1.14.14.1 {ECO:0000256|ARBA:ARBA00012109};
GN Name=CYP6B13 {ECO:0000313|EMBL:AAK69498.1};
OS Papilio canadensis (Canadian tiger swallowtail butterfly) (Pterourus
OS canadensis).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio; Pterourus.
OX NCBI_TaxID=77246 {ECO:0000313|EMBL:AAK69498.1};
RN [1] {ECO:0000313|EMBL:AAK69498.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11483436; DOI=10.1016/S0965-1748(01)00048-0;
RA Li W., Berenbaum M.R., Schuler M.A.;
RT "Molecular analysis of multiple CYP6B genes from polyphagous Papilio
RT species.";
RL Insect Biochem. Mol. Biol. 31:999-1011(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC ChEBI:CHEBI:142491; EC=1.14.14.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001025};
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004174}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004174}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AF280616; AAK69498.1; -; Genomic_DNA.
DR AlphaFoldDB; Q95WW5; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd11056; CYP6-like; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24292; CYTOCHROME P450; 1.
DR PANTHER; PTHR24292:SF103; CYTOCHROME P450 6A14-LIKE PROTEIN-RELATED; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|ARBA:ARBA00023033,
KW ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU000461}.
SQ SEQUENCE 500 AA; 57961 MW; 8616E9FA911CEAD7 CRC64;
MLTIFIVTAT LFAILYLYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR KHLIMIYKDI
YEAFPKAKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN DRGVEFSEEG LGLNIFHADG
DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG DKFIKMVEKI CDKEPEQQII PLVRKFTMAS
ITTCAFGMEL DEEMFESLDK LDSLIFTTSY GNEIDMMYPG ILKKLNSSLF SKMIAPFFDN
LTKTIIEQRG GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF
YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS EMTYLTQVFH
ETLRKYPVAD ILLRNAKADY VVPGTNVTLK KGQTVVVSGF GIHYDPKYYP DPEKFDPERF
SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ WQVQVCIFKL LSKFRFDPST KTMSEFNYDP
TRLLVYPKSG IFLNILPRNY
//
