ID Q95Z92_LEIMA Unreviewed; 725 AA.
AC Q95Z92;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Putative cAMP-specific phosphodiesterase {ECO:0000313|EMBL:CAC44911.1};
GN ORFNames=LMJF_04_0030 {ECO:0000313|EMBL:CAC44911.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAC44911.1, ECO:0000313|Proteomes:UP000000542};
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Friedlin;
RX PubMed=9477341;
RA Ivens A.C., Lewis S.M., Bagherzadeh A., Zhang L., Chan H.M., Smith D.F.;
RT "A physical map of the Leishmania major Friedlin genome.";
RL Genome Res. 8:135-145(1998).
RN [2] {ECO:0000313|EMBL:CAC44911.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [3] {ECO:0000313|EMBL:CAC44911.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796400; CAC44911.1; -; Genomic_DNA.
DR RefSeq; XP_888514.1; XM_883421.1.
DR AlphaFoldDB; Q95Z92; -.
DR STRING; 5664.Q95Z92; -.
DR EnsemblProtists; CAC44911; CAC44911; LMJF_04_0030.
DR GeneID; 3684826; -.
DR KEGG; lma:LMJF_04_0030; -.
DR VEuPathDB; TriTrypDB:LmjF.04.0030; -.
DR VEuPathDB; TriTrypDB:LMJFC_040005400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_040005200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_040005200; -.
DR eggNOG; KOG3689; Eukaryota.
DR HOGENOM; CLU_381966_0_0_1; -.
DR InParanoid; Q95Z92; -.
DR OMA; RCEHYFS; -.
DR Proteomes; UP000000542; Chromosome 4.
DR GO; GO:0005930; C:axoneme; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.10.1300.10; 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain; 1.
DR InterPro; IPR002073; PDEase_catalytic_dom.
DR InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR PANTHER; PTHR11347:SF222; CAMP-SPECIFIC PHOSPHODIESTERASE-RELATED; 1.
DR PANTHER; PTHR11347; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; 1.
DR Pfam; PF00233; PDEase_I; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51845; PDEASE_I_2; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 116..292
FT /note="PDEase"
FT /evidence="ECO:0000259|PROSITE:PS51845"
FT REGION 494..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 725 AA; 79238 MW; DC46843DD038782F CRC64;
MCPFDVLASV KDDPSLSPQL REKIGGALTR LREICKTADQ PSVAKALPRS CAHNYFKEMI
SGHAPLRFSC HSSESTHTRV KHFDIASSRL PGPIVMSSSK TLMQRTTPAL QSPKEIFAEL
NVIAFQTLRY IDEVEQIEFD VTNVREHDGS IMEDKERLFL SVCCSVFANF SFFASLHINA
EKFLHFLRKL FTCYPLDNSY HNATHAADAL QMMSLFFREP TVNFLFSDEE IAICFLAVLA
VDVAHPGASD TLLVALDHPL ASVFGDVAIT EHASLLVLTS LLVLEDNFFF STPDMAVSVD
SAHLLKEALY DVVLNAALRS RPSLMSALRD IETSGRITDA DAPKLMAALL VMACNSFAFR
SQAQCCRMGA WFLSELHREE CEMERHGIRV TLPHVAGADC AAVLSDYINV VVKPVTAATL
ALVPRDLQDR LEWNADLVDA AASTGGRACK VVVENSLVQW MTSSLSVMEI LKKVATHASS
VDRKASKCAI LNASPSRSQG TAPDMMRADS LSSNSSTSGS MSAAKRDEAT SNCPQLSFTS
EPCSAAGSPT ARPGRSEHYF SFLRLYDKCE RAGESAKNFV GQLIFLALQL DPRYIAAYAR
KEYGDDCCGA ECAEMGLLIS KMEEAPSTAE VIASRPPGGS FSNRVADEID HTDSFVLLLM
DMYCSREAAL AEMESVVLVS DKAKTPPPAE PAAPKAVPQF QQNSPIRMPV NTESKNTGPR
LRLVP
//
