ID Q961B0_DROME Unreviewed; 1067 AA.
AC Q961B0;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=LD24920p {ECO:0000313|EMBL:AAK93143.1};
GN Name=Apc2 {ECO:0000313|EMBL:AAK93143.1,
GN ECO:0000313|FlyBase:FBgn0026598};
GN ORFNames=CG6193 {ECO:0000313|FlyBase:FBgn0026598};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK93143.1};
RN [1] {ECO:0000313|EMBL:AAK93143.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:AAK93143.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA Rubin G.M., Celniker S.;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenomatous polyposis coli (APC) family.
CC {ECO:0000256|ARBA:ARBA00009051}.
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DR EMBL; AY051719; AAK93143.1; -; mRNA.
DR AlphaFoldDB; Q961B0; -.
DR AGR; FB:FBgn0026598; -.
DR FlyBase; FBgn0026598; Apc2.
DR VEuPathDB; VectorBase:FBgn0026598; -.
DR HOGENOM; CLU_009924_0_0_1; -.
DR ExpressionAtlas; Q961B0; baseline and differential.
DR GO; GO:0045180; C:basal cortex; IDA:FlyBase.
DR GO; GO:0030877; C:beta-catenin destruction complex; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0005938; C:cell cortex; IDA:FlyBase.
DR GO; GO:0032154; C:cleavage furrow; IDA:FlyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
DR GO; GO:0030425; C:dendrite; IDA:FlyBase.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043025; C:neuronal cell body; IDA:FlyBase.
DR GO; GO:0032991; C:protein-containing complex; IPI:FlyBase.
DR GO; GO:0008013; F:beta-catenin binding; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IGI:FlyBase.
DR GO; GO:0007155; P:cell adhesion; IMP:FlyBase.
DR GO; GO:0001708; P:cell fate specification; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0008362; P:chitin-based embryonic cuticle biosynthetic process; IMP:FlyBase.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IMP:FlyBase.
DR GO; GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IMP:FlyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:FlyBase.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IGI:FlyBase.
DR GO; GO:0007026; P:negative regulation of microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0007405; P:neuroblast proliferation; IGI:FlyBase.
DR GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IMP:FlyBase.
DR GO; GO:0007389; P:pattern specification process; IBA:GO_Central.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0030589; P:pseudocleavage involved in syncytial blastoderm formation; IMP:FlyBase.
DR GO; GO:0045595; P:regulation of cell differentiation; IBA:GO_Central.
DR GO; GO:0035190; P:syncytial nuclear migration; IMP:FlyBase.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR009240; APC_15aa_rpt.
DR InterPro; IPR026818; Apc_fam.
DR InterPro; IPR041257; APC_rep.
DR InterPro; IPR009223; APC_rpt.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR PANTHER; PTHR12607; ADENOMATOUS POLYPOSIS COLI PROTEIN FAMILY; 1.
DR PANTHER; PTHR12607:SF12; APC-LIKE, ISOFORM A-RELATED; 1.
DR Pfam; PF05972; APC_15aa; 2.
DR Pfam; PF05923; APC_r; 4.
DR Pfam; PF18797; APC_rep; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 2: Evidence at transcript level;
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT REPEAT 281..315
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 410..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 956..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 984..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 116679 MW; 03C4119AEF19D198 CRC64;
MTLNESDATR LELTRNFLEL SRNPETCTAL RSSDCIQLLV QILHANDEGL STAKKYASQA
LHNIVHNNPE EKERQREVKM LRLLDQILDY CNFLHTQLQS GGEAIADDED RHPLAAMKLL
MKASFDEEHR QTMCELGALK AIPNLVHLDH AVHGPAAGME QCNALRSYGL MALTNLTFGD
ENVHNKSYLC GQRQFMEVVI AQLNTAPDEL LQVLAGVLRN LSWRADKHMK TIFNELGTVT
SLARAAMQNK NENTLKAILS ALWNLSAHCS TNKAEFCAVD GALAFLVGML SYEGPSKTLK
IIENAGGILR NVSSHIAVCE PYRQILRRYN CLAILLQQLK SESLTVVSNS CGTLWNLSAR
CPEDQQYLID HNAIPLLRAL ISSKNSMIAE GSASALKNLV NFRATQELMP NGDGGSLPLD
KEAGHGGTLP RRFSSLRLSS NPTGSLKKVR PSTVSTTGFL NRKCESRESI YSGKSDSTKY
STKSEGAKNP FEIVTPTEEQ PIDYSMKYME HKPNSSKTFE IDLDQPTDFS ARYKERRSAQ
TAQPELKSET NEIRSKELQL TKSSSATELR NSPGLVAVSA AKQKIATETE TETAERPINY
CEEGTPGSFS RFDSLNSLTE KPEKCMPPKT PTKTAVLPVH VDGNTPQNID SALETPLMFS
RRSSMDSLVG DDETVACEDN GSVISEYSRM QSGVISPSEL PDSPTQSMPQ SPRRDRKVST
QNNLDTPEQK PSTVFEDKLN RFHVEHTPAA FSCATSLSNL SMMDDSNANA IRGQRGNDIN
GNGDAPRSYC TEDTTAVLSK APSNSDLSIL SIPNDLNANE AQPVPAPRAD VTGMDTRMPA
EDAISKMRCG GNALPSYLPV SDEMSKYYVE DSPCTFSVIS GLSHLTVGSA KAGPVLKLPM
RTAEEAQAPK LPPRRSAVQG DAEPRLPPKK SDSLSSLSMD SDDDCNLLSQ AIAAGSCRPQ
PSGASTSSSL ANASTSTLCR ENGQSKKQVE HGDKPNYSSD DSLDDDDDDA RSKSLFEQCI
LSGMHKSNDA LESEGEPPGQ RQEISARDRF VSNQVRQIES MLAGRQH
//
