ID Q961K9_DROME Unreviewed; 576 AA.
AC Q961K9;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE RecName: Full=glycerol kinase {ECO:0000256|ARBA:ARBA00012099};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
GN Name=Gk2 {ECO:0000313|FlyBase:FBgn0035266};
GN Synonyms=Gk {ECO:0000313|FlyBase:FBgn0035266};
GN ORFNames=CG7995 {ECO:0000313|EMBL:AAK92959.1,
GN ECO:0000313|FlyBase:FBgn0035266};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK92959.1};
RN [1] {ECO:0000313|EMBL:AAK92959.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Berkeley {ECO:0000313|EMBL:AAK92959.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M.,
RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M.,
RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J.,
RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E.,
RA Rubin G.M., Celniker S.;
RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR EMBL; AY051535; AAK92959.1; -; mRNA.
DR AlphaFoldDB; Q961K9; -.
DR PeptideAtlas; Q961K9; -.
DR AGR; FB:FBgn0035266; -.
DR FlyBase; FBgn0035266; Gk2.
DR VEuPathDB; VectorBase:FBgn0035266; -.
DR HOGENOM; CLU_009281_2_3_1; -.
DR UniPathway; UPA00618; UER00672.
DR ExpressionAtlas; Q961K9; baseline and differential.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004370; F:glycerol kinase activity; IMP:FlyBase.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006071; P:glycerol metabolic process; IBA:GO_Central.
DR GO; GO:0046167; P:glycerol-3-phosphate biosynthetic process; IMP:FlyBase.
DR GO; GO:0016310; P:phosphorylation; IMP:FlyBase.
DR GO; GO:0006641; P:triglyceride metabolic process; IBA:GO_Central.
DR CDD; cd07792; FGGY_GK1-3_metazoa; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR042018; GK1-3_metazoa.
DR InterPro; IPR005999; Glycerol_kin.
DR NCBIfam; TIGR01311; glycerol_kin; 1.
DR PANTHER; PTHR10196:SF40; GLYCEROL KINASE; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003733};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 33..284
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 299..483
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 576 AA; 64636 MW; 490A414231ECBDBA CRC64;
MTEGKNLPHS SADVPFRSKE LRKQSLIQHT GLVGVIDEGT KTIGFSIYTT PDFKEIAAHR
VELSVITPQD GWYEQDPLEM MASINKCAEE AIKQLPEQGF SASDIVTVGI TNQRETTIVW
DAVTGKPLYN ALLWKDIRTS TTVEQIVAKV QDPNHFRSST GLPISTYFSA LKIRWLRDNV
PEVRQAIRER RCKAGTVDSW IVWNLTNGAL HITDVTNASR TLLMNLETQA WDPVLLKTFG
IREEMLPTIH SCSEIFGKIT SERSPLRGMT LSGIMGNQQA SLLGQMCVKP GQTKNTYRSG
CFLLCNTGDK PVFSRHGLLT TVAYKLGPQA PTIYAIEGAV SVAGHALSWL QNKVRILPDS
RDAEKYAEMV PTSGDVYFVP AFTGLYAPYW RQNARGIIIG LTQFTRKNHI VRAALESICF
QTRDILECMH QECGYEINKL HADGKLTTNN LLMQLQADTI GMPVFRSQLM DSTAFGAAMC
AAQADGVNLC QFEPEKRYYE NVHYDTFLAT TTYVERKERY GKWKRAVERS LGWVIKQKKT
REYTEENYRM LSSLPASIFL ISSFAMLVHS LAASGQ
//