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Database: UniProt
Entry: Q96569_SOLLC
LinkDB: Q96569_SOLLC
Original site: Q96569_SOLLC 
ID   Q96569_SOLLC            Unreviewed;       350 AA.
AC   Q96569;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   24-JAN-2024, entry version 163.
DE   RecName: Full=L-lactate dehydrogenase {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
DE            EC=1.1.1.27 {ECO:0000256|ARBA:ARBA00012967, ECO:0000256|RuleBase:RU000496};
GN   Name=ldh {ECO:0000313|EMBL:CAA70100.1};
GN   Synonyms=101252012 {ECO:0000313|EnsemblPlants:Solyc08g078850.3.1},
GN   ldh1 {ECO:0000313|EMBL:CAA71611.1};
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081 {ECO:0000313|EMBL:CAA70100.1};
RN   [1] {ECO:0000313|EMBL:CAA70100.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=9426593; DOI=10.1023/A:1005854002969;
RA   Germain V., Raymond P., Ricard B.;
RT   "Differential expression of two tomato lactate dehydrogenase genes in
RT   response to oxygen deficit.";
RL   Plant Mol. Biol. 35:711-721(1997).
RN   [2] {ECO:0000313|EMBL:CAA71611.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Fruit {ECO:0000313|EMBL:CAA71611.1};
RX   PubMed=9426613; DOI=10.1023/A:1005821304013;
RA   Germain V., Ricard B.;
RT   "Two ldh genes from tomato and their expression in different organs, during
RT   fruit ripening and in response to stress.";
RL   Plant Mol. Biol. 35:949-954(1997).
RN   [3] {ECO:0000313|EnsemblPlants:Solyc08g078850.3.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc08g078850.3.1};
RX   PubMed=22660326; DOI=10.1038/nature11119;
RG   Tomato Genome Consortium;
RT   "The tomato genome sequence provides insights into fleshy fruit
RT   evolution.";
RL   Nature 485:635-641(2012).
RN   [4] {ECO:0000313|EnsemblPlants:Solyc08g078850.3.1}
RP   IDENTIFICATION.
RC   STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc08g078850.3.1};
RG   EnsemblPlants;
RL   Submitted (JAN-2019) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-lactate + NAD(+) = H(+) + NADH + pyruvate;
CC         Xref=Rhea:RHEA:23444, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16651, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.27;
CC         Evidence={ECO:0000256|ARBA:ARBA00001763,
CC         ECO:0000256|RuleBase:RU000496};
CC   -!- PATHWAY: Fermentation; pyruvate fermentation to lactate; (S)-lactate
CC       from pyruvate: step 1/1. {ECO:0000256|ARBA:ARBA00004843,
CC       ECO:0000256|RuleBase:RU000496}.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. LDH family.
CC       {ECO:0000256|ARBA:ARBA00006054}.
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DR   EMBL; Y08887; CAA70100.1; -; mRNA.
DR   EMBL; Y10602; CAA71611.1; -; Genomic_DNA.
DR   PIR; T07061; T07061.
DR   RefSeq; NP_001266265.1; NM_001279336.1.
DR   AlphaFoldDB; Q96569; -.
DR   STRING; 4081.Q96569; -.
DR   PaxDb; 4081-Solyc08g078850-2-1; -.
DR   EnsemblPlants; Solyc08g078850.3.1; Solyc08g078850.3.1; Solyc08g078850.3.
DR   GeneID; 101252012; -.
DR   Gramene; Solyc08g078850.3.1; Solyc08g078850.3.1; Solyc08g078850.3.
DR   KEGG; sly:101252012; -.
DR   eggNOG; KOG1495; Eukaryota.
DR   HOGENOM; CLU_045401_0_2_1; -.
DR   InParanoid; Q96569; -.
DR   OMA; ASCAEYI; -.
DR   OrthoDB; 5344346at2759; -.
DR   UniPathway; UPA00554; UER00611.
DR   Proteomes; UP000004994; Chromosome 8.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004459; F:L-lactate dehydrogenase activity; IBA:GO_Central.
DR   GO; GO:0006089; P:lactate metabolic process; IBA:GO_Central.
DR   GO; GO:0006090; P:pyruvate metabolic process; IBA:GO_Central.
DR   CDD; cd05293; LDH_1; 1.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   HAMAP; MF_00488; Lactate_dehydrog; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR011304; L-lactate_DH.
DR   InterPro; IPR018177; L-lactate_DH_AS.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01771; L-LDH-NAD; 1.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00064; L_LDH; 1.
PE   2: Evidence at transcript level;
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU000496};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004994}.
FT   DOMAIN          38..177
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          180..343
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        210
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         44..49
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         69
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         130
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         153..155
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   350 AA;  37708 MW;  3957C1D4FB04D70F CRC64;
     MQNSSSSSSL GPGGLDLTQA FFKSISNAAP PSPTKRHTKI SVIGVGNVGM AIAQTILTQD
     LVDELALVDA KSDKLRGEML DLQHAAAFLP RTKIHASIDY SVTAGSDLCI VTAGARQNPG
     ESRLNLLQRN MALFRSIIPP LVKYSPETTL LVVSNPVDVL TYVAWKLSGF PANRVIGSGT
     NLDSSRFRFL IADHLDVNAQ DVQAYIVGEH GDSSVALWSG ISVGGVPVLS FLERQQIALE
     KETLEKIHQE VVHSAYEVIS LKGYTSWAIG YSVANLARTI LRDQRRIHPV SVLAKGFYGI
     DGGDVFLSLP AQLGRSGVLG VTNVHLTDEE IEQLRNSAKT ILEVQSQLGI
//
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