ID Q969Z2_HUMAN Unreviewed; 244 AA.
AC Q969Z2;
DT 01-DEC-2001, integrated into UniProtKB/TrEMBL.
DT 01-DEC-2001, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=SAM-dependent methyltransferase {ECO:0000313|EMBL:AAL18604.1};
DE SubName: Full=cDNA FLJ25072 fis, clone CBL05716 {ECO:0000313|EMBL:BAB71581.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAB71581.1};
RN [1] {ECO:0000313|EMBL:AAL18604.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Placenta {ECO:0000313|EMBL:AAL18604.1};
RA Zhang Y., Gorry M.C., Hart P.S., Pettenati M.J., Lu X., Hart T.C.;
RT "Genomic organization and alternative transcription of a novel human SAM-
RT dependent methyltransferase gene on chromosome 2p21.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BAB71581.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Cerebellum {ECO:0000313|EMBL:BAB71581.1};
RA Nishi T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Suzuki Y.,
RA Hata H., Nakagawa K., Mizuno S., Morinaga M., Kawamura M., Sugiyama T.,
RA Irie R., Otsuki T., Sato H., Nishikawa T., Sugiyama A., Kawakami B.,
RA Nagai K., Isogai T., Sugano S.;
RT "NEDO human cDNA sequencing project.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AF380577; AAL18604.1; -; mRNA.
DR EMBL; AF380578; AAL18605.1; -; mRNA.
DR EMBL; AF380579; AAL18606.1; -; mRNA.
DR EMBL; AH011179; AAL26318.1; -; Genomic_DNA.
DR EMBL; AF380572; AAL26318.1; JOINED; Genomic_DNA.
DR EMBL; AF380573; AAL26318.1; JOINED; Genomic_DNA.
DR EMBL; AF380574; AAL26318.1; JOINED; Genomic_DNA.
DR EMBL; AK057801; BAB71581.1; -; mRNA.
DR RefSeq; NP_001308399.1; NM_001321470.1.
DR RefSeq; NP_079540.2; NM_025264.4.
DR AlphaFoldDB; Q969Z2; -.
DR SMR; Q969Z2; -.
DR MaxQB; Q969Z2; -.
DR PeptideAtlas; Q969Z2; -.
DR DNASU; 80745; -.
DR GeneID; 80745; -.
DR KEGG; hsa:80745; -.
DR CTD; 80745; -.
DR OrthoDB; 5406466at2759; -.
DR BioGRID-ORCS; 80745; 18 hits in 1154 CRISPR screens.
DR GenomeRNAi; 80745; -.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0034470; P:ncRNA processing; IEA:UniProt.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR14911; THUMP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14911:SF1; THUMP DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01170; UPF0020; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 2: Evidence at transcript level;
KW Methyltransferase {ECO:0000313|EMBL:AAL18604.1};
KW Transferase {ECO:0000313|EMBL:AAL18604.1}.
FT DOMAIN 40..153
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
SQ SEQUENCE 244 AA; 26449 MW; 4C6CBA4A9F1C9A81 CRC64;
MALTETWLCT EDSASSVDIS SGGCLFSPIS STTGPDSGAG AFVLDPMCGL GTILLEAAKE
WPDVYYVGAD VSDSQLLGTW DNLKAAGLED KIELLKISVI ELPLPSESVD IIISDIPFGK
KFKLGKDIKS ILQEMERVLH VGGTIVLLLS EDHHRRLTDC KESNIPFNSK DSHTDEPGIK
KCLNPEEKTG AFKTASTSFE ASNHKFLDRM SPFGSLVPVE CYKVSLGKTD AFICKYKKSH
SSGL
//
