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Database: UniProt
Entry: Q96LU5
LinkDB: Q96LU5
Original site: Q96LU5 
ID   IMP1L_HUMAN             Reviewed;         166 AA.
AC   Q96LU5; D3DQZ7; Q96SH9;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-SEP-2014, entry version 106.
DE   RecName: Full=Mitochondrial inner membrane protease subunit 1;
DE            EC=3.4.21.-;
DE   AltName: Full=IMP1-like protein;
GN   Name=IMMP1L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F.,
RA   Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E.,
RA   FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S.,
RA   Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W.,
RA   Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S.,
RA   Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=15814844; DOI=10.1091/mbc.E04-12-1086;
RA   Burri L., Strahm Y., Hawkins C.J., Gentle I.E., Puryer M.A.,
RA   Verhagen A., Callus B., Vaux D., Lithgow T.;
RT   "Mature DIABLO/Smac is produced by the IMP protease complex on the
RT   mitochondrial inner membrane.";
RL   Mol. Biol. Cell 16:2926-2933(2005).
CC   -!- FUNCTION: Catalyzes the removal of transit peptides required for
CC       the targeting of proteins from the mitochondrial matrix, across
CC       the inner membrane, into the inter-membrane space. Known to
CC       process the nuclear encoded protein DIABLO.
CC   -!- SUBUNIT: Heterodimer of 2 subunits, IMMPL1 and IMMPL2 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane (Probable).
CC   -!- SIMILARITY: Belongs to the peptidase S26 family. IMP1 subfamily.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC39221.1; Type=Erroneous gene model prediction;
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DR   EMBL; AK057788; BAB71573.1; -; mRNA.
DR   EMBL; AL133295; CAC39221.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CH471064; EAW68239.1; -; Genomic_DNA.
DR   EMBL; CH471064; EAW68240.1; -; Genomic_DNA.
DR   EMBL; BC023595; AAH23595.1; -; mRNA.
DR   CCDS; CCDS7874.1; -.
DR   RefSeq; NP_659418.1; NM_144981.1.
DR   RefSeq; XP_005252868.1; XM_005252811.1.
DR   RefSeq; XP_005252869.1; XM_005252812.1.
DR   RefSeq; XP_005252871.1; XM_005252814.1.
DR   RefSeq; XP_006718231.1; XM_006718168.1.
DR   UniGene; Hs.502223; -.
DR   ProteinModelPortal; Q96LU5; -.
DR   SMR; Q96LU5; 40-144.
DR   STRING; 9606.ENSP00000278200; -.
DR   MEROPS; S26.A05; -.
DR   DMDM; 74752020; -.
DR   MaxQB; Q96LU5; -.
DR   PaxDb; Q96LU5; -.
DR   PRIDE; Q96LU5; -.
DR   Ensembl; ENST00000278200; ENSP00000278200; ENSG00000148950.
DR   Ensembl; ENST00000532287; ENSP00000435576; ENSG00000148950.
DR   GeneID; 196294; -.
DR   KEGG; hsa:196294; -.
DR   UCSC; uc001msy.1; human.
DR   CTD; 196294; -.
DR   GeneCards; GC11M031411; -.
DR   HGNC; HGNC:26317; IMMP1L.
DR   HPA; HPA038372; -.
DR   MIM; 612323; gene.
DR   neXtProt; NX_Q96LU5; -.
DR   PharmGKB; PA142671655; -.
DR   eggNOG; COG0681; -.
DR   HOGENOM; HOG000003673; -.
DR   HOVERGEN; HBG080010; -.
DR   InParanoid; Q96LU5; -.
DR   KO; K09647; -.
DR   OMA; RCYGPVP; -.
DR   PhylomeDB; Q96LU5; -.
DR   TreeFam; TF315083; -.
DR   ChiTaRS; IMMP1L; human.
DR   GenomeRNAi; 196294; -.
DR   NextBio; 89429; -.
DR   PRO; PR:Q96LU5; -.
DR   ArrayExpress; Q96LU5; -.
DR   Bgee; Q96LU5; -.
DR   CleanEx; HS_IMMP1L; -.
DR   Genevestigator; Q96LU5; -.
DR   GO; GO:0042720; C:mitochondrial inner membrane peptidase complex; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006627; P:protein processing involved in protein targeting to mitochondrion; IEA:InterPro.
DR   Gene3D; 2.10.109.10; -; 1.
DR   InterPro; IPR026730; Mitochondrial_IMP1.
DR   InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR   InterPro; IPR028360; Peptidase_S24/S26_b-rbn.
DR   InterPro; IPR019759; Peptidase_S24_S26.
DR   InterPro; IPR015927; Peptidase_S24_S26A/B/C.
DR   PANTHER; PTHR12383; PTHR12383; 1.
DR   PANTHER; PTHR12383:SF14; PTHR12383:SF14; 1.
DR   Pfam; PF00717; Peptidase_S24; 1.
DR   PRINTS; PR00727; LEADERPTASE.
DR   SUPFAM; SSF51306; SSF51306; 1.
DR   TIGRFAMs; TIGR02227; sigpep_I_bact; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Hydrolase; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Protease; Reference proteome.
FT   CHAIN         1    166       Mitochondrial inner membrane protease
FT                                subunit 1.
FT                                /FTId=PRO_0000259573.
FT   ACT_SITE     40     40       By similarity.
FT   ACT_SITE     83     83       By similarity.
SQ   SEQUENCE   166 AA;  18504 MW;  53E4EB65757BA71A CRC64;
     MLRGVLGKTF RLVGYTIQYG CIAHCAFEYV GGVVMCSGPS MEPTIQNSDI VFAENLSRHF
     YGIQRGDIVI AKSPSDPKSN ICKRVIGLEG DKILTTSPSD FFKSHSYVPM GHVWLEGDNL
     QNSTDSRCYG PIPYGLIRGR IFFKIWPLSD FGFLRASPNG HRFSDD
//
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