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Database: UniProt
Entry: Q96P68
LinkDB: Q96P68
Original site: Q96P68 
ID   OXGR1_HUMAN             Reviewed;         337 AA.
AC   Q96P68; Q5T5A7; Q86TL1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   26-NOV-2014, entry version 113.
DE   RecName: Full=2-oxoglutarate receptor 1;
DE   AltName: Full=Alpha-ketoglutarate receptor 1;
DE   AltName: Full=G-protein coupled receptor 80;
DE   AltName: Full=G-protein coupled receptor 99;
DE   AltName: Full=P2Y purinoceptor 15;
DE            Short=P2Y15;
DE   AltName: Full=P2Y-like GPCR;
DE   AltName: Full=P2Y-like nucleotide receptor;
GN   Name=OXGR1; Synonyms=GPR80, GPR99, P2RY15, P2Y15;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5;
RA   Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA   Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT   "Discovery and mapping of ten novel G protein-coupled receptor
RT   genes.";
RL   Gene 275:83-91(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RX   PubMed=12098360; DOI=10.1186/1471-2164-3-17;
RA   Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J.,
RA   Schaller H.C., Hampe W.;
RT   "GPR99, a new G protein-coupled receptor with homology to a new
RT   subgroup of nucleotide receptors.";
RL   BMC Genomics 3:17-17(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8;
RA   Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT   "Identification of G protein-coupled receptor genes from the human
RT   genome sequence.";
RL   FEBS Lett. 520:97-101(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Thyroid;
RA   Bruess M., Bonisch H., von Kugelgen I.;
RT   "Molecular cloning and functional characterization of a new human P2Y
RT   receptor.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for alpha-ketoglutarate. Seems to act
CC       exclusively through a G(q)-mediated pathway (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Detected in kidney and, to a lower extend, in
CC       placenta. Not detected in brain tissues including the frontal
CC       cortex, caudate putamen, thalamus, hypothalamus, hippocampus or
CC       pons.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: Was originally (Ref.5) thought to be a P2Y receptor.
CC       {ECO:0000305}.
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DR   EMBL; AF411109; AAL26480.1; -; Genomic_DNA.
DR   EMBL; AF370886; AAM76912.1; -; mRNA.
DR   EMBL; AB083598; BAB89311.1; -; Genomic_DNA.
DR   EMBL; AB065877; BAC06095.1; -; Genomic_DNA.
DR   EMBL; AJ305372; CAC83857.1; -; mRNA.
DR   EMBL; AL356486; CAI16508.1; -; Genomic_DNA.
DR   EMBL; BC103881; AAI03882.1; -; mRNA.
DR   EMBL; BC103882; AAI03883.1; -; mRNA.
DR   EMBL; BC103883; AAI03884.1; -; mRNA.
DR   CCDS; CCDS9482.1; -.
DR   RefSeq; NP_543008.3; NM_080818.3.
DR   RefSeq; XP_005254100.1; XM_005254043.1.
DR   RefSeq; XP_005254101.1; XM_005254044.1.
DR   RefSeq; XP_005254102.1; XM_005254045.1.
DR   RefSeq; XP_005254103.1; XM_005254046.1.
DR   UniGene; Hs.352218; -.
DR   ProteinModelPortal; Q96P68; -.
DR   SMR; Q96P68; 24-312.
DR   STRING; 9606.ENSP00000298440; -.
DR   BindingDB; Q96P68; -.
DR   ChEMBL; CHEMBL2150840; -.
DR   GuidetoPHARMACOLOGY; 162; -.
DR   DMDM; 48474598; -.
DR   PRIDE; Q96P68; -.
DR   DNASU; 27199; -.
DR   Ensembl; ENST00000298440; ENSP00000298440; ENSG00000165621.
DR   Ensembl; ENST00000543457; ENSP00000438800; ENSG00000165621.
DR   GeneID; 27199; -.
DR   KEGG; hsa:27199; -.
DR   UCSC; uc001vmx.1; human.
DR   CTD; 27199; -.
DR   GeneCards; GC13M097637; -.
DR   HGNC; HGNC:4531; OXGR1.
DR   MIM; 606922; gene.
DR   neXtProt; NX_Q96P68; -.
DR   PharmGKB; PA28924; -.
DR   eggNOG; NOG146579; -.
DR   GeneTree; ENSGT00760000118784; -.
DR   HOGENOM; HOG000231307; -.
DR   HOVERGEN; HBG106870; -.
DR   InParanoid; Q96P68; -.
DR   KO; K08419; -.
DR   OMA; GFHFNLY; -.
DR   OrthoDB; EOG7Z95MM; -.
DR   PhylomeDB; Q96P68; -.
DR   TreeFam; TF330775; -.
DR   Reactome; REACT_14828; Class A/1 (Rhodopsin-like receptors).
DR   Reactome; REACT_19231; G alpha (i) signalling events.
DR   GeneWiki; OXGR1; -.
DR   GenomeRNAi; 27199; -.
DR   NextBio; 50066; -.
DR   PRO; PR:Q96P68; -.
DR   Bgee; Q96P68; -.
DR   CleanEx; HS_OXGR1; -.
DR   ExpressionAtlas; Q96P68; baseline.
DR   Genevestigator; Q96P68; -.
DR   GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    337       2-oxoglutarate receptor 1.
FT                                /FTId=PRO_0000069994.
FT   TOPO_DOM      1     34       Extracellular. {ECO:0000255}.
FT   TRANSMEM     35     55       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     56     69       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     70     90       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     91    116       Extracellular. {ECO:0000255}.
FT   TRANSMEM    117    137       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    138    151       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    152    172       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    173    201       Extracellular. {ECO:0000255}.
FT   TRANSMEM    202    222       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    223    242       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    243    263       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    264    284       Extracellular. {ECO:0000255}.
FT   TRANSMEM    285    305       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    306    337       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD     10     10       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD     23     23       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    176    176       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    179    179       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID    106    183       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   CONFLICT     14     14       F -> L (in Ref. 5; CAC83857).
FT                                {ECO:0000305}.
FT   CONFLICT    236    236       K -> R (in Ref. 5; CAC83857).
FT                                {ECO:0000305}.
SQ   SEQUENCE   337 AA;  38251 MW;  6814EA0044756CE6 CRC64;
     MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF
     KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS
     ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR
     SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR
     RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL
     LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP
//
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