ID OXGR1_HUMAN Reviewed; 337 AA.
AC Q96P68; Q5T5A7; Q86TL1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 01-MAY-2013, entry version 97.
DE RecName: Full=2-oxoglutarate receptor 1;
DE AltName: Full=Alpha-ketoglutarate receptor 1;
DE AltName: Full=G-protein coupled receptor 80;
DE AltName: Full=G-protein coupled receptor 99;
DE AltName: Full=P2Y purinoceptor 15;
DE Short=P2Y15;
DE AltName: Full=P2Y-like GPCR;
DE AltName: Full=P2Y-like nucleotide receptor;
GN Name=OXGR1; Synonyms=GPR80, GPR99, P2RY15, P2Y15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11574155; DOI=10.1016/S0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor
RT genes.";
RL Gene 275:83-91(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=12098360;
RA Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J.,
RA Schaller H.C., Hampe W.;
RT "GPR99, a new G protein-coupled receptor with homology to a new
RT subgroup of nucleotide receptors.";
RL BMC Genomics 3:17-17(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/S0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human
RT genome sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RA Bruess M., Bonisch H., von Kugelgen I.;
RT "Molecular cloning and functional characterization of a new human P2Y
RT receptor.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for alpha-ketoglutarate. Seems to act
CC exclusively through a G(q)-mediated pathway (By similarity).
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in kidney and, to a lower extend, in
CC placenta. Not detected in brain tissues including the frontal
CC cortex, caudate putamen, thalamus, hypothalamus, hippocampus or
CC pons.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC -!- CAUTION: Was originally (Ref.5) thought to be a P2Y receptor.
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DR EMBL; AF411109; AAL26480.1; -; Genomic_DNA.
DR EMBL; AF370886; AAM76912.1; -; mRNA.
DR EMBL; AB083598; BAB89311.1; -; Genomic_DNA.
DR EMBL; AB065877; BAC06095.1; -; Genomic_DNA.
DR EMBL; AJ305372; CAC83857.1; -; mRNA.
DR EMBL; AL356486; CAI16508.1; -; Genomic_DNA.
DR EMBL; BC103881; AAI03882.1; -; mRNA.
DR EMBL; BC103882; AAI03883.1; -; mRNA.
DR EMBL; BC103883; AAI03884.1; -; mRNA.
DR IPI; IPI00044282; -.
DR RefSeq; NP_543008.3; NM_080818.3.
DR UniGene; Hs.352218; -.
DR ProteinModelPortal; Q96P68; -.
DR STRING; 9606.ENSP00000298440; -.
DR DMDM; 48474598; -.
DR PRIDE; Q96P68; -.
DR DNASU; 27199; -.
DR Ensembl; ENST00000298440; ENSP00000298440; ENSG00000165621.
DR Ensembl; ENST00000543457; ENSP00000438800; ENSG00000165621.
DR GeneID; 27199; -.
DR KEGG; hsa:27199; -.
DR UCSC; uc001vmx.1; human.
DR CTD; 27199; -.
DR GeneCards; GC13M097637; -.
DR HGNC; HGNC:4531; OXGR1.
DR MIM; 606922; gene.
DR neXtProt; NX_Q96P68; -.
DR PharmGKB; PA28924; -.
DR eggNOG; NOG146579; -.
DR HOGENOM; HOG000231307; -.
DR HOVERGEN; HBG106870; -.
DR InParanoid; Q96P68; -.
DR KO; K08419; -.
DR OMA; GFHFNLY; -.
DR OrthoDB; EOG46HGBH; -.
DR PhylomeDB; Q96P68; -.
DR GenomeRNAi; 27199; -.
DR NextBio; 50066; -.
DR ArrayExpress; Q96P68; -.
DR Bgee; Q96P68; -.
DR CleanEx; HS_OXGR1; -.
DR Genevestigator; Q96P68; -.
DR GermOnline; ENSG00000165621; Homo sapiens.
DR GO; GO:0016021; C:integral to membrane; TAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002286; P2_purnocptor.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01157; P2YPURNOCPTR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 337 2-oxoglutarate receptor 1.
FT /FTId=PRO_0000069994.
FT TOPO_DOM 1 34 Extracellular (Potential).
FT TRANSMEM 35 55 Helical; Name=1; (Potential).
FT TOPO_DOM 56 69 Cytoplasmic (Potential).
FT TRANSMEM 70 90 Helical; Name=2; (Potential).
FT TOPO_DOM 91 116 Extracellular (Potential).
FT TRANSMEM 117 137 Helical; Name=3; (Potential).
FT TOPO_DOM 138 151 Cytoplasmic (Potential).
FT TRANSMEM 152 172 Helical; Name=4; (Potential).
FT TOPO_DOM 173 201 Extracellular (Potential).
FT TRANSMEM 202 222 Helical; Name=5; (Potential).
FT TOPO_DOM 223 242 Cytoplasmic (Potential).
FT TRANSMEM 243 263 Helical; Name=6; (Potential).
FT TOPO_DOM 264 284 Extracellular (Potential).
FT TRANSMEM 285 305 Helical; Name=7; (Potential).
FT TOPO_DOM 306 337 Cytoplasmic (Potential).
FT CARBOHYD 10 10 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 23 23 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 176 176 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 179 179 N-linked (GlcNAc...) (Potential).
FT DISULFID 106 183 By similarity.
FT CONFLICT 14 14 F -> L (in Ref. 5; CAC83857).
FT CONFLICT 236 236 K -> R (in Ref. 5; CAC83857).
SQ SEQUENCE 337 AA; 38251 MW; 6814EA0044756CE6 CRC64;
MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF
KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS
ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR
SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR
RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL
LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP
//
