ID HEM3_THEVO Reviewed; 297 AA.
AC Q97B26;
DT 25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 01-MAY-2013, entry version 79.
DE RecName: Full=Probable porphobilinogen deaminase;
DE Short=PBG;
DE EC=2.5.1.61;
DE AltName: Full=Hydroxymethylbilane synthase;
DE Short=HMBS;
DE AltName: Full=Pre-uroporphyrinogen synthase;
GN Name=hemC; OrderedLocusNames=TV0633; ORFNames=TVG0625731;
OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS 15438 / GSS1).
OC Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S.,
RA Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T.,
RA Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT "Archaeal adaptation to higher temperatures revealed by genomic
RT sequence of Thermoplasma volcanium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
CC (By similarity).
CC -!- CATALYTIC ACTIVITY: 4 porphobilinogen + H(2)O =
CC hydroxymethylbilane + 4 NH(3).
CC -!- COFACTOR: Binds 1 dipyrromethane group covalently (By similarity).
CC -!- PATHWAY: Porphyrin metabolism; protoporphyrin-IX biosynthesis;
CC coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC -!- MISCELLANEOUS: The porphobilinogen subunits are added to the
CC dipyrromethane group (By similarity).
CC -!- SIMILARITY: Belongs to the HMBS family.
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DR EMBL; BA000011; BAB59775.1; -; Genomic_DNA.
DR RefSeq; NP_111153.1; NC_002689.2.
DR ProteinModelPortal; Q97B26; -.
DR STRING; 273116.TVN0634; -.
DR EnsemblBacteria; BAB59775; BAB59775; BAB59775.
DR GeneID; 1441740; -.
DR KEGG; tvo:TVN0634; -.
DR eggNOG; COG0181; -.
DR KO; K01749; -.
DR OMA; QPLRGNV; -.
DR ProtClustDB; PRK00072; -.
DR UniPathway; UPA00251; UER00319.
DR GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:HAMAP.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:HAMAP.
DR GO; GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.160.40; -; 1.
DR HAMAP; MF_00260; Porphobil_deam; 1; -.
DR InterPro; IPR000860; 4pyrrol_synth_OHMeBilane_synth.
DR InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR InterPro; IPR022417; Porphobilin_deaminase_N.
DR InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR PANTHER; PTHR11557; PTHR11557; 1.
DR Pfam; PF01379; Porphobil_deam; 1.
DR PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR PRINTS; PR00151; PORPHBDMNASE.
DR SUPFAM; SSF54782; Porphobil_deam; 1.
DR TIGRFAMs; TIGR00212; hemC; 1.
DR PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE 3: Inferred from homology;
KW Complete proteome; Porphyrin biosynthesis; Transferase.
FT CHAIN 1 297 Probable porphobilinogen deaminase.
FT /FTId=PRO_0000143033.
FT MOD_RES 233 233 S-(dipyrrolylmethanemethyl)cysteine (By
FT similarity).
SQ SEQUENCE 297 AA; 32892 MW; 01067904DF95820D CRC64;
MKIKIGTRPS NLAVAQANMV ASSLEAIGID TEIVKHRSAG DIDTKNPIYS IGKTGVFVQD
LNNMILRGEI DVAVHSAKDI PSEIENRLTI AATLKRGSFN DALVSKYDLR SLPISAKVGT
SSIRRIFQLK YARQDLKFEN IRGNIETRIA KMSELGLDAI VMAEAAIQRL GLNVEYSKLD
ENKFVPAPNQ GIIAVVSKKE GTVRKILEEI NDENTFEEMQ IERSVVQQLK LGCSTPVGIL
SRPSGKGHKI IAQFFSMQGD DVSVFEQYLN DLSDVDSLVS YIRENIPREY GYIASEE
//
