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Database: UniProt
Entry: Q97B26
LinkDB: Q97B26
Original site: Q97B26 
ID   HEM3_THEVO              Reviewed;         297 AA.
AC   Q97B26;
DT   25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-SEP-2014, entry version 85.
DE   RecName: Full=Probable porphobilinogen deaminase;
DE            Short=PBG;
DE            EC=2.5.1.61;
DE   AltName: Full=Hydroxymethylbilane synthase;
DE            Short=HMBS;
DE   AltName: Full=Pre-uroporphyrinogen synthase;
GN   Name=hemC; OrderedLocusNames=TV0633; ORFNames=TVG0625731;
OS   Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS   15438 / GSS1).
OC   Archaea; Euryarchaeota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1;
RX   PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA   Kawashima T., Amano N., Koike H., Makino S., Higuchi S.,
RA   Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T.,
RA   Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT   "Archaeal adaptation to higher temperatures revealed by genomic
RT   sequence of Thermoplasma volcanium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC   -!- FUNCTION: Tetrapolymerization of the monopyrrole PBG into the
CC       hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: 4 porphobilinogen + H(2)O =
CC       hydroxymethylbilane + 4 NH(3).
CC   -!- COFACTOR: Binds 1 dipyrromethane group covalently (By similarity).
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-
CC       IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate:
CC       step 2/4.
CC   -!- MISCELLANEOUS: The porphobilinogen subunits are added to the
CC       dipyrromethane group (By similarity).
CC   -!- SIMILARITY: Belongs to the HMBS family.
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DR   EMBL; BA000011; BAB59775.1; -; Genomic_DNA.
DR   RefSeq; NP_111153.1; NC_002689.2.
DR   RefSeq; WP_010916892.1; NC_002689.2.
DR   ProteinModelPortal; Q97B26; -.
DR   STRING; 273116.TVN0634; -.
DR   EnsemblBacteria; BAB59775; BAB59775; BAB59775.
DR   GeneID; 1441740; -.
DR   KEGG; tvo:TVN0634; -.
DR   eggNOG; COG0181; -.
DR   KO; K01749; -.
DR   OMA; AICIECL; -.
DR   BioCyc; TVOL273116:GC31-658-MONOMER; -.
DR   UniPathway; UPA00251; UER00319.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.160.40; -; 1.
DR   HAMAP; MF_00260; Porphobil_deam; 1.
DR   InterPro; IPR000860; 4pyrrol_synth_OHMeBilane_synth.
DR   InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR   PANTHER; PTHR11557; PTHR11557; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
DR   SUPFAM; SSF54782; SSF54782; 1.
DR   TIGRFAMs; TIGR00212; hemC; 1.
DR   PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Porphyrin biosynthesis; Transferase.
FT   CHAIN         1    297       Probable porphobilinogen deaminase.
FT                                /FTId=PRO_0000143033.
FT   MOD_RES     233    233       S-(dipyrrolylmethanemethyl)cysteine (By
FT                                similarity).
SQ   SEQUENCE   297 AA;  32892 MW;  01067904DF95820D CRC64;
     MKIKIGTRPS NLAVAQANMV ASSLEAIGID TEIVKHRSAG DIDTKNPIYS IGKTGVFVQD
     LNNMILRGEI DVAVHSAKDI PSEIENRLTI AATLKRGSFN DALVSKYDLR SLPISAKVGT
     SSIRRIFQLK YARQDLKFEN IRGNIETRIA KMSELGLDAI VMAEAAIQRL GLNVEYSKLD
     ENKFVPAPNQ GIIAVVSKKE GTVRKILEEI NDENTFEEMQ IERSVVQQLK LGCSTPVGIL
     SRPSGKGHKI IAQFFSMQGD DVSVFEQYLN DLSDVDSLVS YIRENIPREY GYIASEE
//
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