ID Q97C94_THEVO Unreviewed; 1013 AA.
AC Q97C94;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:BAB59351.1};
GN ORFNames=TVG0218327 {ECO:0000313|EMBL:BAB59351.1};
OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC
OS 15438 / GSS1).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273116 {ECO:0000313|EMBL:BAB59351.1, ECO:0000313|Proteomes:UP000001017};
RN [1] {ECO:0000313|EMBL:BAB59351.1, ECO:0000313|Proteomes:UP000001017}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1
RC {ECO:0000313|Proteomes:UP000001017};
RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257;
RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y.,
RA Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T.,
RA Yamamoto Y., Aramaki H., Makino K., Suzuki M.;
RT "Archaeal adaptation to higher temperatures revealed by genomic sequence of
RT Thermoplasma volcanium.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
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DR EMBL; BA000011; BAB59351.1; -; Genomic_DNA.
DR RefSeq; WP_010916465.1; NC_002689.2.
DR AlphaFoldDB; Q97C94; -.
DR STRING; 273116.gene:9380979; -.
DR CAZy; GH38; Glycoside Hydrolase Family 38.
DR PaxDb; 273116-14324423; -.
DR GeneID; 1440725; -.
DR KEGG; tvo:TVG0218327; -.
DR eggNOG; arCOG03661; Archaea.
DR HOGENOM; CLU_003442_1_0_2; -.
DR OrthoDB; 35948at2157; -.
DR PhylomeDB; Q97C94; -.
DR Proteomes; UP000001017; Chromosome.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR Gene3D; 2.60.40.2220; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 512..587
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1013 AA; 118484 MW; C76581440EF4D2DD CRC64;
MLKISKRSII LRKIYEIISL SIIEIKEISN IKLNNNNIKI PYSTFQDPNE IKDFSFEVNL
DQLDDGYKYL LSVELSGNAE LIIDGMLDQS IDAGHTYSIF DGPKHEFVLR VGSRELFGKN
SWYLNIKSIK IITINYKLFK LGLNFLQLFK YADTTSRSKL RIYNYMLKYL LTLYESPNIE
QIMGIGSIFL NKNKEELVDF LSDVYGYPII NHMIKDYPRK DINLYKYTNV LEHIIKTIAA
SDNKYKTNKV FAFGHCHIDV AWLWPYSETL RKIERSFLNV LKLYEMGFNF VFAQSTALYY
YEIEKRNVYI FNKIRRLVND GKWFIVGGMW VESDTNLIRG ESLARQLLYG QGYFKEVFNR
YSRIAWLPDT FGFSGQLPQL FVKSGMEVFV THKPMWNDTT EFPYHCFKWF GIDGTPIITS
IVNLSYNENL DFDSVVNAYK SNKNKNLPIT YLYGYGDGGG GPDIEMMLKL EQIKDLQFMP
NVNGSFSEQE YIDSFKEFYK EMPSYFGEIY LENHRGVYTT NLEIKKYVAN IEDKLIMLDF
INSMIYNSKL YISNTKKLWY GLLKAQFHDI LPGSAYYYAY EEAFAELDDI ILEIDKITEF
AIRKFIEDKN IKKGLIAINN SQYEFNHFVE IDNSLASEIP ADKVVNVGDK KFVLVNVPPL
GFSVINTNTE NKFENEIKIR KIKGKYIIEN KIIKLIINSV GIISFFYNNK RYIKKGNIVK
IYNDIPANFD SWNINAQNIR KDLFMDEIKT EIRVISKNII GMVEIKKIFE DGSSIIQKII
IRPGSSIVEF ENTLLLKNRE KLVKVVFQPY FHADYIKREI PFGYIMTKLN SKNEKTRPEF
PALRYVDYSD NSHGFSILSR ESHGYSFING ELGISIAKVP LYPNPFSDRN EVREKFYVYL
HNEYYNIYKD ANFVFNPIKL HVNEYDGDNV RESLFNFSGE NIILENIKVA EDNSGLVTRF
YNCSDKMSTL ELNFPGGDIY ETDILENKQV KYNKNIIFKP FEIKTLLIEK NNL
//
