ID Q97MU5_CLOAB Unreviewed; 215 AA.
AC Q97MU5;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=precorrin-2 dehydrogenase {ECO:0000256|ARBA:ARBA00012400};
DE EC=1.3.1.76 {ECO:0000256|ARBA:ARBA00012400};
GN Name=hemW {ECO:0000313|EMBL:AAK78081.1};
GN OrderedLocusNames=CA_C0096 {ECO:0000313|EMBL:AAK78081.1};
OS Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710
OS / VKM B-1787).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=272562 {ECO:0000313|EMBL:AAK78081.1, ECO:0000313|Proteomes:UP000000814};
RN [1] {ECO:0000313|EMBL:AAK78081.1, ECO:0000313|Proteomes:UP000000814}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787
RC {ECO:0000313|Proteomes:UP000000814};
RX PubMed=11466286; DOI=10.1128/JB.183.16.4823-4838.2001;
RA Nolling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R.,
RA Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F.,
RA Doucette-Stamm L., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V.,
RA Smith D.R.;
RT "Genome sequence and comparative analysis of the solvent-producing
RT bacterium Clostridium acetobutylicum.";
RL J. Bacteriol. 183:4823-4838(2001).
CC -!- PATHWAY: Porphyrin-containing compound metabolism; siroheme
CC biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005010}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE001437; AAK78081.1; -; Genomic_DNA.
DR PIR; F96911; F96911.
DR RefSeq; NP_346741.1; NC_003030.1.
DR RefSeq; WP_010963423.1; NC_003030.1.
DR AlphaFoldDB; Q97MU5; -.
DR STRING; 272562.CA_C0096; -.
DR GeneID; 44996578; -.
DR KEGG; cac:CA_C0096; -.
DR PATRIC; fig|272562.8.peg.279; -.
DR eggNOG; COG1648; Bacteria.
DR HOGENOM; CLU_011276_8_4_9; -.
DR OrthoDB; 1715866at2; -.
DR UniPathway; UPA00262; UER00222.
DR Proteomes; UP000000814; Chromosome.
DR GO; GO:0004325; F:ferrochelatase activity; IEA:InterPro.
DR GO; GO:0043115; F:precorrin-2 dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR028161; Met8-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR35330; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR PANTHER; PTHR35330:SF1; SIROHEME BIOSYNTHESIS PROTEIN MET8; 1.
DR Pfam; PF13241; NAD_binding_7; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000000814}.
SQ SEQUENCE 215 AA; 25345 MW; 66E0F3EAA4BEA6A7 CRC64;
MPKDIKKDIS EVENLFIALV SPKLKILVIG GGNAALIKVR NFIKMGCLIT IVSKEFKEEF
NMLSGFPNIK LIKGEYLRDY LKHYHIIIIA TNNFKLNDKI RQDCDYINKM YMDCGEPEKG
LYIVPYQNDS KMFSLSIKSR YKSPKTSKYV LDKAMTFIKR YEDFSEYTAN IRNKIKGSRK
KEIMNFVCSD DFYFFYKKRK ADIVLQMFYR ELNGE
//
