ID Q98318_MCV1 Unreviewed; 354 AA.
AC Q98318; O12533; O12618; O12822; O12899;
DT 01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT 01-FEB-1997, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=H-M-N-7 protein {ECO:0000313|EMBL:AAB58023.1};
DE SubName: Full=MC152R {ECO:0000313|EMBL:AAC55280.1};
GN Name=MC152R {ECO:0000313|EMBL:AAC55280.1};
GN Synonyms=H-M-N-7 {ECO:0000313|EMBL:AAB58023.1};
OS Molluscum contagiosum virus subtype 1 (MOCV) (MCVI).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Molluscipoxvirus;
OC Molluscum contagiosum virus.
OX NCBI_TaxID=10280 {ECO:0000313|EMBL:AAC55280.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAC55280.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=8670425; DOI=10.1126/science.273.5276.813;
RA Senkevich T.G., Bugert J.J., Sisler J.R., Koonin E.V., Darai G., Moss B.;
RT "Genome sequence of a human tumorigenic poxvirus: prediction of specific
RT host response-evasion genes.";
RL Science 273:813-816(1996).
RN [2] {ECO:0000313|EMBL:AAB58023.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9208457; DOI=10.1023/A:1007991508159;
RA Moratilla M., Agromayor M., Nunez A., Funes J.M., Varas A.J.,
RA Lopez-Estebaranz J.L., Esteban M., Martin-Gallardo A.;
RT "A random DNA sequencing, computer-based approach for the generation of a
RT gene map of Molluscum contagiosum virus.";
RL Virus Genes 14:73-80(1997).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|RuleBase:RU004475}.
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DR EMBL; U86945; AAB58023.1; -; Genomic_DNA.
DR EMBL; U60315; AAC55280.1; -; Genomic_DNA.
DR PIR; T30754; T30754.
DR RefSeq; NP_044103.1; NC_001731.1.
DR GeneID; 1487171; -.
DR KEGG; vg:1487171; -.
DR OrthoDB; 8536at10239; -.
DR Proteomes; UP000000869; Genome.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF835; 3 BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 7; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000000869}.
FT DOMAIN 5..277
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 354 AA; 39601 MW; B2FD53409BEA30E2 CRC64;
MKVYAVTGGG GFIGSYIVRA LLQCERTLIE LRVIDVRWGT KVSSRNVNVV YIYCDVCDTA
RLCAALEGVD VLIHTAGLVD VMGEYSEDEI YRANVHGTHS ALSACVCAGV RFVVYTSSME
VVGPNMRAEP FVGDEKTEYE SCHQHCYPRS KAEAEELVLS SNGRRVRGGQ RMLTCALRPP
GVYGEGNQLL LRLAKNYVRM GLHVPRTVCE NALQSRVYVG NVAWMHVLAA RALQEPDSRL
PGNAYFCYDH SPCMDYEAFN VMLLRSFGVE LGGPRLPRAL LTVAAYTNAA LQWLLRQLGI
RFSPLLNPYT LAVANACFVI RTRKAREHMG YEPIHNWKQS RKNTTRWLRS QLAS
//
