ID P2RY3_CHICK Reviewed; 328 AA.
AC Q98907;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-APR-2013, entry version 81.
DE RecName: Full=P2Y purinoceptor 3;
DE Short=P2Y3;
DE AltName: Full=Nucleoside diphosphate receptor;
GN Name=P2RY3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=8700132;
RA Webb T.E., Henderson D., King B.F., Wang S., Simon J., Bateson A.N.,
RA Burnstock G., Barnard E.A.;
RT "A novel G protein-coupled P2 purinoceptor (P2Y3) activated
RT preferentially by nucleoside diphosphates.";
RL Mol. Pharmacol. 50:258-265(1996).
CC -!- FUNCTION: Receptor for extracellular ADP > UTP > ATP = UDP. The
CC activity of this receptor is mediated by G proteins which activate
CC a phosphatidylinositol-calcium second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
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DR EMBL; X98283; CAA66930.1; -; mRNA.
DR IPI; IPI00591717; -.
DR RefSeq; NP_990526.1; NM_205195.1.
DR UniGene; Gga.660; -.
DR ProteinModelPortal; Q98907; -.
DR STRING; 9031.ENSGALP00000027948; -.
DR PaxDb; Q98907; -.
DR Ensembl; ENSGALT00000028001; ENSGALP00000027948; ENSGALG00000017327.
DR GeneID; 396114; -.
DR KEGG; gga:396114; -.
DR CTD; 5031; -.
DR eggNOG; NOG149481; -.
DR GeneTree; ENSGT00700000104024; -.
DR HOGENOM; HOG000231307; -.
DR HOVERGEN; HBG101120; -.
DR InParanoid; Q98907; -.
DR KO; K04272; -.
DR OMA; PYGMALT; -.
DR OrthoDB; EOG4QVCCG; -.
DR NextBio; 20816172; -.
DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR GO; GO:0045029; F:UDP-activated nucleotide receptor activity; IEA:Compara.
DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Compara.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002286; P2_purnocptor.
DR InterPro; IPR000371; P2Y3_purnocptor.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01065; P2Y3PRNOCPTR.
DR PRINTS; PR01157; P2YPURNOCPTR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Complete proteome; Disulfide bond;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1 328 P2Y purinoceptor 3.
FT /FTId=PRO_0000070017.
FT TOPO_DOM 1 22 Extracellular (Potential).
FT TRANSMEM 23 43 Helical; Name=1; (Potential).
FT TOPO_DOM 44 57 Cytoplasmic (Potential).
FT TRANSMEM 58 78 Helical; Name=2; (Potential).
FT TOPO_DOM 79 96 Extracellular (Potential).
FT TRANSMEM 97 117 Helical; Name=3; (Potential).
FT TOPO_DOM 118 139 Cytoplasmic (Potential).
FT TRANSMEM 140 160 Helical; Name=4; (Potential).
FT TOPO_DOM 161 189 Extracellular (Potential).
FT TRANSMEM 190 210 Helical; Name=5; (Potential).
FT TOPO_DOM 211 231 Cytoplasmic (Potential).
FT TRANSMEM 232 252 Helical; Name=6; (Potential).
FT TOPO_DOM 253 275 Extracellular (Potential).
FT TRANSMEM 276 298 Helical; Name=7; (Potential).
FT TOPO_DOM 299 323 Cytoplasmic (Potential).
FT CARBOHYD 5 5 N-linked (GlcNAc...) (Potential).
FT DISULFID 94 172 By similarity.
SQ SEQUENCE 328 AA; 37587 MW; 7A3BF1C91F54FAAB CRC64;
MSMANFTGGR NSCTFHEEFK QVLLPLVYSV VFLLGLPLNA VVIGQIWLAR KALTRTTIYM
LNLAMADLLY VCSLPLLIYN YTQKDYWPFG DFTCKFVRFQ FYTNLHGSIL FLTCISVQRY
MGICHPLASW HKKKGKKLTW LVCAAVWFIV IAQCLPTFVF ASTGTQRNRT VCYDLSPPDR
STSYFPYGIT LTITGFLLPF AAILACYCSM ARILCQKDEL IGLAVHKKKD KAVRMIIIVV
IVFSISFFPF HLTKTIYLIV RSSASLPCPT LQAFAIAYKC TRPFASMNSV LDPILFYFTQ
RKFRESTRYL LDKMSSKWRQ DHCISYGS
//
