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Database: UniProt
Entry: Q98907
LinkDB: Q98907
Original site: Q98907 
ID   P2RY3_CHICK             Reviewed;         328 AA.
AC   Q98907;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   29-OCT-2014, entry version 92.
DE   RecName: Full=P2Y purinoceptor 3;
DE            Short=P2Y3;
DE   AltName: Full=Nucleoside diphosphate receptor;
GN   Name=P2RY3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Testudines + Archosauria group; Archosauria; Dinosauria; Saurischia;
OC   Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8700132;
RA   Webb T.E., Henderson D., King B.F., Wang S., Simon J., Bateson A.N.,
RA   Burnstock G., Barnard E.A.;
RT   "A novel G protein-coupled P2 purinoceptor (P2Y3) activated
RT   preferentially by nucleoside diphosphates.";
RL   Mol. Pharmacol. 50:258-265(1996).
CC   -!- FUNCTION: Receptor for extracellular ADP > UTP > ATP = UDP. The
CC       activity of this receptor is mediated by G proteins which activate
CC       a phosphatidylinositol-calcium second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; X98283; CAA66930.1; -; mRNA.
DR   RefSeq; NP_990526.1; NM_205195.1.
DR   UniGene; Gga.660; -.
DR   ProteinModelPortal; Q98907; -.
DR   STRING; 9031.ENSGALP00000027948; -.
DR   PaxDb; Q98907; -.
DR   Ensembl; ENSGALT00000028001; ENSGALP00000027948; ENSGALG00000017327.
DR   GeneID; 396114; -.
DR   KEGG; gga:396114; -.
DR   CTD; 5031; -.
DR   eggNOG; NOG149481; -.
DR   GeneTree; ENSGT00760000118784; -.
DR   HOGENOM; HOG000231307; -.
DR   HOVERGEN; HBG101120; -.
DR   InParanoid; Q98907; -.
DR   KO; K04272; -.
DR   OMA; FQRYLGI; -.
DR   OrthoDB; EOG7P2XSD; -.
DR   PhylomeDB; Q98907; -.
DR   TreeFam; TF330775; -.
DR   NextBio; 20816172; -.
DR   PRO; PR:Q98907; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IEA:InterPro.
DR   GO; GO:0045029; F:UDP-activated nucleotide receptor activity; IEA:Ensembl.
DR   GO; GO:0007200; P:phospholipase C-activating G-protein coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0030321; P:transepithelial chloride transport; IEA:Ensembl.
DR   Gene3D; 1.20.1070.10; -; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000371; P2Y3_rcpt.
DR   InterPro; IPR001973; P2Y6_rcpt.
DR   PANTHER; PTHR24231:SF16; PTHR24231:SF16; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01065; P2Y3PRNOCPTR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN         1    328       P2Y purinoceptor 3.
FT                                /FTId=PRO_0000070017.
FT   TOPO_DOM      1     22       Extracellular. {ECO:0000255}.
FT   TRANSMEM     23     43       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     44     57       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     58     78       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     79     96       Extracellular. {ECO:0000255}.
FT   TRANSMEM     97    117       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    118    139       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    140    160       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    161    189       Extracellular. {ECO:0000255}.
FT   TRANSMEM    190    210       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    211    231       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    232    252       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    253    275       Extracellular. {ECO:0000255}.
FT   TRANSMEM    276    298       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    299    323       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      5      5       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     94    172       {ECO:0000255|PROSITE-ProRule:PRU00521}.
SQ   SEQUENCE   328 AA;  37587 MW;  7A3BF1C91F54FAAB CRC64;
     MSMANFTGGR NSCTFHEEFK QVLLPLVYSV VFLLGLPLNA VVIGQIWLAR KALTRTTIYM
     LNLAMADLLY VCSLPLLIYN YTQKDYWPFG DFTCKFVRFQ FYTNLHGSIL FLTCISVQRY
     MGICHPLASW HKKKGKKLTW LVCAAVWFIV IAQCLPTFVF ASTGTQRNRT VCYDLSPPDR
     STSYFPYGIT LTITGFLLPF AAILACYCSM ARILCQKDEL IGLAVHKKKD KAVRMIIIVV
     IVFSISFFPF HLTKTIYLIV RSSASLPCPT LQAFAIAYKC TRPFASMNSV LDPILFYFTQ
     RKFRESTRYL LDKMSSKWRQ DHCISYGS
//
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