ID UBIE_RHILO Reviewed; 258 AA.
AC Q98GV1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 29-MAY-2013, entry version 68.
DE RecName: Full=Ubiquinone/menaquinone biosynthesis methyltransferase ubiE;
DE EC=2.1.1.163;
DE EC=2.1.1.201;
DE AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE AltName: Full=Demethylmenaquinone methyltransferase;
GN Name=ubiE; OrderedLocusNames=mlr3165;
OS Rhizobium loti (strain MAFF303099) (Mesorhizobium loti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=266835;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAFF303099;
RX PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T.,
RA Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M.,
RA Takeuchi C., Yamada M., Tabata S.;
RT "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT Mesorhizobium loti.";
RL DNA Res. 7:331-338(2000).
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
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DR EMBL; BA000012; BAB50115.1; -; Genomic_DNA.
DR RefSeq; NP_104329.1; NC_002678.2.
DR ProteinModelPortal; Q98GV1; -.
DR STRING; 266835.mlr3165; -.
DR EnsemblBacteria; BAB50115; BAB50115; BAB50115.
DR GeneID; 1226990; -.
DR KEGG; mlo:mlr3165; -.
DR PATRIC; 22479235; VBIMesLot2464_2521.
DR eggNOG; COG2226; -.
DR HOGENOM; HOG000249463; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR ProtClustDB; PRK00216; -.
DR BioCyc; MLOT266835:GJ9L-2456-MONOMER; -.
DR UniPathway; UPA00079; UER00169.
DR UniPathway; UPA00232; -.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR InterPro; IPR025765; UbiE/COQ5_MeTrFase_dom.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase; Ubiquinone biosynthesis.
FT CHAIN 1 258 Ubiquinone/menaquinone biosynthesis
FT methyltransferase ubiE.
FT /FTId=PRO_0000193315.
SQ SEQUENCE 258 AA; 28291 MW; 9909682B726B2828 CRC64;
MSVERTTAAG GMETSYGFKR VGEGEKQSLV NDVFHKVANR YDLMNDLMSA GLHRLWKDAM
VTWLNPPKRP GWKVLDVAGG TGDIAFRIVD ASHGNAHATV LDINGSMLGV GRDRAQKKGL
SGNTDFVEAN AEELPFADAT FDAYTIAFGI RNVPRIDVAL SEAFRVLKPG GRFLCLEFSE
VEMPLLDKAY EAWSFNAIPK IGKMVTGDGE PYSYLVESIA KFPNQQNFAA MISRAGFDRV
SFRNYSGGIA ALHSGWKL
//
