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Database: UniProt
Entry: Q98GV1
LinkDB: Q98GV1
Original site: Q98GV1 
ID   UBIE_RHILO              Reviewed;         258 AA.
AC   Q98GV1;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-SEP-2014, entry version 78.
DE   RecName: Full=Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE;
DE            EC=2.1.1.163;
DE            EC=2.1.1.201;
DE   AltName: Full=2-methoxy-6-polyprenyl-1,4-benzoquinol methylase;
DE   AltName: Full=Demethylmenaquinone methyltransferase;
GN   Name=ubiE; OrderedLocusNames=mlr3165;
OS   Rhizobium loti (strain MAFF303099) (Mesorhizobium loti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Phyllobacteriaceae; Mesorhizobium.
OX   NCBI_TaxID=266835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAFF303099;
RX   PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA   Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA   Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T.,
RA   Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Mochizuki Y., Nakayama S., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takeuchi C., Yamada M., Tabata S.;
RT   "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT   Mesorhizobium loti.";
RL   DNA Res. 7:331-338(2000).
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the
CC       conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to
CC       2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + 2-methoxy-6-all-
CC       trans-polyprenyl-1,4-benzoquinol = S-adenosyl-L-homocysteine + 6-
CC       methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8.
CC   -!- PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family.
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DR   EMBL; BA000012; BAB50115.1; -; Genomic_DNA.
DR   RefSeq; NP_104329.1; NC_002678.2.
DR   RefSeq; WP_010911462.1; NC_002678.2.
DR   ProteinModelPortal; Q98GV1; -.
DR   STRING; 266835.mlr3165; -.
DR   EnsemblBacteria; BAB50115; BAB50115; BAB50115.
DR   GeneID; 1226990; -.
DR   KEGG; mlo:mlr3165; -.
DR   PATRIC; 22479235; VBIMesLot2464_2521.
DR   eggNOG; COG2226; -.
DR   HOGENOM; HOG000249463; -.
DR   KO; K03183; -.
DR   OMA; ALNCAIE; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   BioCyc; MLOT266835:GJ9L-2456-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   UniPathway; UPA00232; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases-like.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   S-adenosyl-L-methionine; Transferase; Ubiquinone biosynthesis.
FT   CHAIN         1    258       Ubiquinone/menaquinone biosynthesis C-
FT                                methyltransferase UbiE.
FT                                /FTId=PRO_0000193315.
SQ   SEQUENCE   258 AA;  28291 MW;  9909682B726B2828 CRC64;
     MSVERTTAAG GMETSYGFKR VGEGEKQSLV NDVFHKVANR YDLMNDLMSA GLHRLWKDAM
     VTWLNPPKRP GWKVLDVAGG TGDIAFRIVD ASHGNAHATV LDINGSMLGV GRDRAQKKGL
     SGNTDFVEAN AEELPFADAT FDAYTIAFGI RNVPRIDVAL SEAFRVLKPG GRFLCLEFSE
     VEMPLLDKAY EAWSFNAIPK IGKMVTGDGE PYSYLVESIA KFPNQQNFAA MISRAGFDRV
     SFRNYSGGIA ALHSGWKL
//
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