ID Q98PP2_MYCPU Unreviewed; 520 AA.
AC Q98PP2;
DT 01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2001, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=MYPU_6780 {ECO:0000313|EMBL:CAC13851.1};
OS Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC Bacteria; Mycoplasmatota; Mycoplasmoidales; Metamycoplasmataceae;
OC Mycoplasmopsis.
OX NCBI_TaxID=272635 {ECO:0000313|Proteomes:UP000000528};
RN [1] {ECO:0000313|EMBL:CAC13851.1, ECO:0000313|Proteomes:UP000000528}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP {ECO:0000313|EMBL:CAC13851.1,
RC ECO:0000313|Proteomes:UP000000528};
RX PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; AL445565; CAC13851.1; -; Genomic_DNA.
DR PIR; F90596; F90596.
DR RefSeq; WP_010925479.1; NC_002771.1.
DR AlphaFoldDB; Q98PP2; -.
DR STRING; 272635.gene:17577289; -.
DR REBASE; 5061; M.MpuCORF6780P.
DR KEGG; mpu:MYPU_6780; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_0_2_14; -.
DR BioCyc; MPUL272635:G1GT6-692-MONOMER; -.
DR Proteomes; UP000000528; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR004546; Restrct_endonuc_T1M.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR NCBIfam; TIGR00497; hsdM; 1.
DR PANTHER; PTHR42933:SF1; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC); 1.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:CAC13851.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000528};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAC13851.1}.
FT DOMAIN 9..163
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 173..473
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT COILED 487..514
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 520 AA; 60985 MW; 225C1AA50633A9DA CRC64;
MSNSKELIAV VKKICDQLRS KMEVTEYRDY IMGFLFFKYL SEQSEKNFEE FKERVDYIKY
SEFDENHEQF KKIKEIIIQN DDDFFLAYKY SFQNVVDMMN QGKNVIPTIE ESFNKIESIN
SELNDEKKEF FKDLFTNIDF SNKNLGNIDE EKEKTIQLII KEINTLNLSM DEVDHFGNTY
EYLLSEFASD TGKKAGEFYT PSKVAELLVK IVSHGKNKIN KAYDPACGSG SLLIKLANKV
GKYNKIYGQE VKTATYNLAR MNFILRGVPF SKLDLRSGDT LINPLHIEEE GSFDCIVANP
PFSQKWNPTQ ELSKDRRYNP YPSLAPKSYA DFAFLQHMLF HVNKDNGIIA SVFSLGILSR
KNPKAEEDIR KYIVDENYID TIIFLPPNLF YNTSIESCII VARKNKPTND KRIFMINATK
EFQNAKKQNT LSDENINRIF SAWKEKREEE NFSKYISYED IVKNEYSLSM RFYDLDNFDE
ESEDIDIDFV ESEIVKINEE LLKYENEFKK NLNEFLNKKN
//
