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Database: UniProt
Entry: Q98RK7_MYCPU
LinkDB: Q98RK7_MYCPU
Original site: Q98RK7_MYCPU 
ID   Q98RK7_MYCPU            Unreviewed;       461 AA.
AC   Q98RK7;
DT   01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2001, sequence version 1.
DT   05-JUL-2017, entry version 127.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=MYPU_0010 {ECO:0000313|EMBL:CAC13174.1};
OS   Mycoplasma pulmonis (strain UAB CTIP).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272635 {ECO:0000313|Proteomes:UP000000528};
RN   [1] {ECO:0000313|EMBL:CAC13174.1, ECO:0000313|Proteomes:UP000000528}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAB CTIP {ECO:0000313|EMBL:CAC13174.1,
RC   ECO:0000313|Proteomes:UP000000528};
RX   PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA   Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA   Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C.,
RA   Blanchard A.;
RT   "The complete genome sequence of the murine respiratory pathogen
RT   Mycoplasma pulmonis.";
RL   Nucleic Acids Res. 29:2145-2153(2001).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; AL445563; CAC13174.1; -; Genomic_DNA.
DR   PIR; A90512; A90512.
DR   RefSeq; WP_010924805.1; NC_002771.1.
DR   ProteinModelPortal; Q98RK7; -.
DR   STRING; 272635.MYPU_0010; -.
DR   EnsemblBacteria; CAC13174; CAC13174; CAC13174.
DR   KEGG; mpu:MYPU_0010; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   HOGENOM; HOG000280343; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000000528; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000528};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000528}.
FT   DOMAIN      147    277       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      367    436       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   461 AA;  53675 MW;  3944C4EB2A5FFC7D CRC64;
     MSKKSLDKID LLAYNKTLQD IFESKINDSM LYQNIFKFLE ITKVTFDQVK IAAPNQDVIN
     HLNSDFKEDI KDCIFQLFGE NREITFTSGK KDSSESPKKS EENIQLVEES QNNDELIKKF
     TFDNFIQSKF NENAFLIGKE IIENPGIYNP VLISGDSGLG KTHLLNAIGN EFLKKYPKSI
     VKFLTPSDFY RKIMPILSSN NINENAKKFK ELTEADLVMF DDFQIFSIGN KRATLNFIFE
     ILDKRIMNNK VTILTSDKDL KFMASLFEQR LYTRLSSGLS VEIEQPNKED MLKILKFQLK
     IKNLSPEKWE KDALDFMVRN FSKSIRFLEG ALDKVHFFQL KKQINEFNKL TISNIFKNVE
     ITKENTTPER IIEHVANYYK LPKHELISKS RKSNLVVARD MAIYLIREDL NYSFSRIGLI
     FSNRDHSTIF NSHRKISQSI NSHDSTKYTI TTLRSKINKL S
//
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