ID HXC1A_DANRE Reviewed; 302 AA.
AC Q98SH9; A2BE59; Q4PR93; Q9YGS7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE RecName: Full=Homeobox protein Hox-C1a;
GN Name=hoxc1a; ORFNames=si:dkey-81p22.13;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11493564; DOI=10.1242/dev.128.13.2471;
RA McClintock J.M., Carlson R., Mann D.M., Prince V.E.;
RT "Consequences of Hox gene duplication in the vertebrates: an investigation
RT of the zebrafish Hox paralogue group 1 genes.";
RL Development 128:2471-2484(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 97-197.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 219-302.
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
RN [5]
RP DEVELOPMENTAL STAGE.
RX PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT "Differences in expression pattern and function between zebrafish hoxc13
RT orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL Dev. Biol. 274:318-333(2004).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically, from
CC ova through to 48 hours post-fertilization.
CC {ECO:0000269|PubMed:15385162}.
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DR EMBL; AJ306432; CAC34567.1; -; mRNA.
DR EMBL; BX005254; CAM16413.1; -; Genomic_DNA.
DR EMBL; DQ060550; AAY67928.1; -; mRNA.
DR EMBL; AF071263; AAD15956.1; -; Genomic_DNA.
DR RefSeq; NP_571606.1; NM_131531.1.
DR RefSeq; XP_017209090.1; XM_017353601.1.
DR AlphaFoldDB; Q98SH9; -.
DR SMR; Q98SH9; -.
DR STRING; 7955.ENSDARP00000093905; -.
DR PaxDb; 7955-ENSDARP00000093905; -.
DR GeneID; 58046; -.
DR KEGG; dre:58046; -.
DR AGR; ZFIN:ZDB-GENE-000822-2; -.
DR CTD; 58046; -.
DR ZFIN; ZDB-GENE-000822-2; hoxc1a.
DR eggNOG; KOG0489; Eukaryota.
DR HOGENOM; CLU_921201_0_0_1; -.
DR InParanoid; Q98SH9; -.
DR OMA; GKTFEWM; -.
DR OrthoDB; 728401at2759; -.
DR PhylomeDB; Q98SH9; -.
DR TreeFam; TF317730; -.
DR PRO; PR:Q98SH9; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000070337; Expressed in spinal cord and 13 other cell types or tissues.
DR ExpressionAtlas; Q98SH9; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR046327; HXA1/B1/D1.
DR PANTHER; PTHR45946:SF5; HOMEOBOX PROTEIN HOX-B1; 1.
DR PANTHER; PTHR45946; HOMEOBOX PROTEIN ROUGH-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..302
FT /note="Homeobox protein Hox-C1a"
FT /id="PRO_0000200162"
FT DNA_BIND 215..274
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 198..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 34217 MW; 9A7E6B07B9410E55 CRC64;
MNSYHGFRDT TSLFIKGYHA TGVMRLHQDH GSTADFPSRE DVNNEADFLQ YHFTNLCATA
TGACSKPCED PGRANSTRPP FPQNQDFYRP VHPNRPQVPS FQSCREQGLS RKGFSPSSDT
FRTFSSAHCE LGPVNNTQTE VRTYDGPVRH SAVEDDNTGH GALNTLNETL HSGKTFEWMR
VRRNQSRAAK IQLGKCSDRE LKTNHGRDSD EDTSSGGSRT NFTTKQLTEL EKEFHFNKYL
TRARRIEIAN PLQLSETQVK IWFQNRRMKQ KKMLREGLAQ GLMLISGCDE DSKKSDTCSS
PD
//
