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Database: UniProt
Entry: Q99156
LinkDB: Q99156
Original site: Q99156 
ID   LIP1_YARLI              Reviewed;         486 AA.
AC   Q99156; Q6C6C2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   01-OCT-2014, entry version 69.
DE   RecName: Full=Lipase 1;
DE            EC=3.1.1.3;
DE   Flags: Precursor;
GN   Name=LIP1; OrderedLocusNames=YALI0E10659g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida
OS   lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 90811 / CLIB 163 / JM12;
RA   Gonzalez F.;
RL   Thesis (1996), University of Salamanca, Spain.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate.
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000305}.
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DR   EMBL; Z50020; CAA90323.1; -; Genomic_DNA.
DR   EMBL; CR382131; CAG79381.1; -; Genomic_DNA.
DR   RefSeq; XP_503790.1; XM_503790.1.
DR   ProteinModelPortal; Q99156; -.
DR   EnsemblFungi; CAG79381; CAG79381; YALI0_E10659g.
DR   GeneID; 2912789; -.
DR   KEGG; yli:YALI0E10659g; -.
DR   eggNOG; COG2272; -.
DR   HOGENOM; HOG000113334; -.
DR   OMA; GTISENA; -.
DR   OrthoDB; EOG7M3J88; -.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Disulfide bond; Glycoprotein; Hydrolase;
KW   Lipid degradation; Lipid metabolism; Reference proteome; Signal.
FT   SIGNAL        1      ?       {ECO:0000255}.
FT   CHAIN         ?    486       Lipase 1.
FT                                /FTId=PRO_0000008627.
FT   ACT_SITE    193    193       Acyl-ester intermediate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU10039}.
FT   ACT_SITE    303    303       Charge relay system. {ECO:0000250}.
FT   ACT_SITE    392    392       Charge relay system. {ECO:0000250}.
FT   CARBOHYD    332    332       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     58     82       {ECO:0000250}.
FT   CONFLICT     31     32       IP -> RR (in Ref. 1; CAA90323).
FT                                {ECO:0000305}.
FT   CONFLICT    237    237       N -> D (in Ref. 1; CAA90323).
FT                                {ECO:0000305}.
SQ   SEQUENCE   486 AA;  55380 MW;  497A796EF64D7EA7 CRC64;
     MSVTSTSLNG TFNGISEDGI EIFKGIKYAN IPYRWAYAER IDDYDNGVFD CTQEGMACPQ
     VLPFDYNIEK GPKEMPFDEF ECSNLMITRP QGATNLPVFV WIHGGGNLAG NGYCSDHNPV
     PFVKHSIVAG RPVLHVMIEY RLSAFGYLAV PDTNGNWVGN WGARDQYTAL QWISKHIVEF
     GGDPSQITIG GESAGSIGLH ALMVHESMKP KEECIIHNVI LSSGTMDRMG TGTISENAFK
     PIYDGIKTLV GDINTCSADE LLEAQIKAGL DLGFYLQDDF FPPDWRNVRF KVSRVLLSDV
     IVDGTNFKNK INPAVRVTPE NDFDHKVFKL YNISTEDTWE DYHYKMMLFK GDETFIRGNQ
     QLELLFEQEN IPVWRQLFDQ IHPNDPSRLC HHAVDLYYMW DNWEMPEDKH AVARQYQDTL
     TKFVYGQDPW PVDKLHYVHD NQFEILDKSQ FGDFRNVPAL KFLLGFSAEE LGELTKKYTG
     EGHYTL
//
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