ID Q997W0_9ENTO Unreviewed; 145 AA.
AC Q997W0;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Echovirus E30.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus B.
OX NCBI_TaxID=41846 {ECO:0000313|EMBL:BAB40267.1};
RN [1] {ECO:0000313|EMBL:BAB40267.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M135/85/Aichi {ECO:0000313|EMBL:BAB40267.1};
RX PubMed=10592896;
RA Yoshida H., Hong Z., Yoneyama T., Yoshii K., Shimizu H., Ota K.,
RA Murakami T., Iritani N., Tsuchiya M., Uchida K., Yamanishi S., Hamazaki M.,
RA Yoshino S., Abe K., Hamano M., Sakae K., Tsuzuki H., Chiya S., Onishi H.,
RA Fujimoto T., Munemura T., Kawamoto A., Yokota Y., Sekine H., Akami M.,
RA Iizuka S., Hagiwara A., Miyamura T.;
RT "Phylogenic analysis of echovirus type 30 isolated from a large epidemic of
RT aseptic meningitis in Japan during 1997-1998.";
RL Jpn. J. Infect. Dis. 52:160-163(1999).
RN [2] {ECO:0000313|EMBL:BAB40267.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M135/85/Aichi {ECO:0000313|EMBL:BAB40267.1};
RA Yoshida H.;
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
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DR EMBL; AB058816; BAB40267.1; -; Genomic_RNA.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.20; -; 1.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 1.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..144
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAB40267.1"
FT NON_TER 145
FT /evidence="ECO:0000313|EMBL:BAB40267.1"
SQ SEQUENCE 145 AA; 15862 MW; 4035FD9838267D24 CRC64;
MGAQVSTQKT GAHETGLNAS GNSIIHYTNI NYYKDSASNS LNRQDFTQDP SKFTEPVKDV
MIKTLPALNS PTVEECGYSD RVRSITLGNT TITTQECANV VVGYGVWPTY LSDHEATAVD
QPTQPDVATC RFYTLESVKW ESSSA
//
