ID GBRG3_HUMAN Reviewed; 467 AA.
AC Q99928; Q9HD46; Q9NYT2;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 04-MAY-2001, sequence version 2.
DT 01-MAY-2013, entry version 119.
DE RecName: Full=Gamma-aminobutyric acid receptor subunit gamma-3;
DE AltName: Full=GABA(A) receptor subunit gamma-3;
DE Flags: Precursor;
GN Name=GABRG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal brain;
RX PubMed=8719414; DOI=10.1016/0922-4106(95)90070-5;
RA Hadingham K.L., Wafford K.A., Thompson S.A., Palmer K.J.,
RA Whiting P.J.;
RT "Expression and pharmacology of human GABAA receptors containing gamma
RT 3 subunits.";
RL Eur. J. Pharmacol. 291:301-309(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Han M.K., Chen Y.-H., Nurmi E.L., Sutcliffe J.S.;
RT "Gene structure and organization of the GABAA receptor gamma 3 subunit
RT (GABRG3) gene.";
RL Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-467.
RA Kim S.-J., Gonen D., Yang Z.-Y., Reliford A., Dy A., Leventhal B.L.,
RA Cook E.H. Jr.;
RT "Genomic organization of GABAA receptor gamma 3 subunit gene
RT (GABRG3).";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GABA, the major inhibitory neurotransmitter in the
CC vertebrate brain, mediates neuronal inhibition by binding to the
CC GABA/benzodiazepine receptor and opening an integral chloride
CC channel.
CC -!- SUBUNIT: Generally pentameric. There are five types of GABA(A)
CC receptor chains: alpha, beta, gamma, delta, and rho.
CC -!- SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell
CC membrane; Multi-pass membrane protein. Cell membrane; Multi-pass
CC membrane protein.
CC -!- PTM: May be palmitoylated (By similarity).
CC -!- MISCELLANEOUS: This subunit carries the benzodiazepine binding
CC site.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9)
CC family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily.
CC GABRG3 sub-subfamily.
CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=Forbidden fruit - Issue
CC 56 of March 2005;
CC URL="http://web.expasy.org/spotlight/back_issues/sptlt056.shtml";
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DR EMBL; S82769; AAB39369.1; -; mRNA.
DR EMBL; AF269144; AAF99698.1; -; Genomic_DNA.
DR EMBL; AF269135; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269136; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269137; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269138; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269139; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269140; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269141; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269142; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AF269143; AAF99698.1; JOINED; Genomic_DNA.
DR EMBL; AH009226; AAF63215.1; -; Genomic_DNA.
DR IPI; IPI00294459; -.
DR RefSeq; NP_150092.2; NM_033223.4.
DR UniGene; Hs.569475; -.
DR ProteinModelPortal; Q99928; -.
DR STRING; 9606.ENSP00000331912; -.
DR PhosphoSite; Q99928; -.
DR DMDM; 13959689; -.
DR PaxDb; Q99928; -.
DR PRIDE; Q99928; -.
DR Ensembl; ENST00000333743; ENSP00000331912; ENSG00000182256.
DR GeneID; 2567; -.
DR KEGG; hsa:2567; -.
DR UCSC; uc001zbf.3; human.
DR CTD; 2567; -.
DR GeneCards; GC15P027216; -.
DR H-InvDB; HIX0026811; -.
DR HGNC; HGNC:4088; GABRG3.
DR HPA; HPA054010; -.
DR MIM; 600233; gene.
DR neXtProt; NX_Q99928; -.
DR PharmGKB; PA28502; -.
DR eggNOG; NOG300758; -.
DR HOGENOM; HOG000231337; -.
DR HOVERGEN; HBG051707; -.
DR InParanoid; Q99928; -.
DR KO; K05186; -.
DR OMA; RGRIHID; -.
DR PhylomeDB; Q99928; -.
DR Reactome; REACT_13685; Neuronal System.
DR Reactome; REACT_15518; Transmembrane transport of small molecules.
DR BindingDB; Q99928; -.
DR ChEMBL; CHEMBL2739; -.
DR GenomeRNAi; 2567; -.
DR NextBio; 10153; -.
DR ArrayExpress; Q99928; -.
DR Bgee; Q99928; -.
DR CleanEx; HS_GABRG3; -.
DR Genevestigator; Q99928; -.
DR GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral to membrane; NAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated ion channel activity; NAS:UniProtKB.
DR GO; GO:0004890; F:GABA-A receptor activity; IEA:Compara.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
DR GO; GO:0042493; P:response to drug; IEA:Compara.
DR GO; GO:0007268; P:synaptic transmission; NAS:UniProtKB.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006028; GABAA_rcpt.
DR InterPro; IPR005440; GABBAg3_rcpt.
DR InterPro; IPR005437; GABBAg_rcpt.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR PRINTS; PR01620; GABAARGAMMA.
DR PRINTS; PR01623; GABAARGAMMA3.
DR PRINTS; PR00252; NRIONCHANNEL.
DR SUPFAM; SSF90112; Neu_channel_TM; 1.
DR SUPFAM; SSF63712; Neur_chan_LBD; 1.
DR TIGRFAMs; TIGR00860; LIC; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Chloride; Chloride channel;
KW Complete proteome; Disulfide bond; Glycoprotein; Ion channel;
KW Ion transport; Lipoprotein; Membrane; Palmitate; Polymorphism;
KW Postsynaptic cell membrane; Reference proteome; Signal; Synapse;
KW Transmembrane; Transmembrane helix; Transport.
FT SIGNAL 1 17 Potential.
FT CHAIN 18 467 Gamma-aminobutyric acid receptor subunit
FT gamma-3.
FT /FTId=PRO_0000000481.
FT TOPO_DOM 18 254 Extracellular (Probable).
FT TRANSMEM 255 277 Helical; (Probable).
FT TRANSMEM 281 303 Helical; (Probable).
FT TRANSMEM 315 337 Helical; (Probable).
FT TOPO_DOM 338 443 Cytoplasmic (Probable).
FT TRANSMEM 444 467 Helical; (Probable).
FT CARBOHYD 110 110 N-linked (GlcNAc...) (Potential).
FT CARBOHYD 228 228 N-linked (GlcNAc...) (Potential).
FT DISULFID 171 185 By similarity.
FT VARIANT 352 352 T -> A (in dbSNP:rs2066712).
FT /FTId=VAR_033957.
FT CONFLICT 386 386 T -> P (in Ref. 1; AAB39369).
SQ SEQUENCE 467 AA; 54289 MW; 1B22D145166438D6 CRC64;
MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI LNKLLREYDK
KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ TWTDSRLRFN STMKILTLNS
NMVGLIWIPD TIFRNSKTAE AHWITTPNQL LRIWNDGKIL YTLRLTINAE CQLQLHNFPM
DEHSCPLIFS SYGYPKEEMI YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY
VVMTIYFELS RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK KTTSLLHPDS
SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF EDTCVYECLD GKDCQSFFCC
YEECKSGSWR KGRIHIDILE LDSYSRVFFP TSFLLFNLVY WVGYLYL
//
