ID Q99FJ1_9PICO Unreviewed; 2207 AA.
AC Q99FJ1;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
OS teschovirus A6.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Caphthovirinae; Teschovirus; Teschovirus A.
OX NCBI_TaxID=138683 {ECO:0000313|EMBL:AAK12409.1};
RN [1] {ECO:0000313|EMBL:AAK12409.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Vir 3634/85 {ECO:0000313|EMBL:AAK12409.1};
RX PubMed=11160660; DOI=10.1128/JVI.75.4.1620-1631.2001;
RA Zell R., Dauber M., Krumbholz A., Henke A., Birch-Hirschfeld E.,
RA Stelzner A., Prager D., Wurm R.;
RT "Porcine teschoviruses comprise at least eleven distinct serotypes:
RT molecular and evolutionary aspects.";
RL J. Virol. 75:1620-1631(2001).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Host cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004295}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004295}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004295}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; AF296115; AAK12409.1; -; Genomic_RNA.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044162; C:host cell cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019030; C:icosahedral viral capsid; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0051259; P:protein complex oligomerization; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR GO; GO:0039707; P:virus-mediated pore formation in host cell membrane; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR CDD; cd23212; Teschovirus_RdRp; 1.
DR Gene3D; 1.20.960.20; -; 1.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 4.10.90.10; Capsid protein VP4 superfamily, Picornavirus; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR015031; Capsid_VP4_Picornavir.
DR InterPro; IPR037080; Capsid_VP4_sf_Picornavirus.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR022098; DUF3637.
DR InterPro; IPR000605; Helicase_SF3_ssDNA/RNA_vir.
DR InterPro; IPR014759; Helicase_SF3_ssRNA_vir.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR044067; PCV_3C_PRO.
DR InterPro; IPR000199; Peptidase_C3A/C3B_picornavir.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF12337; DUF3637; 1.
DR Pfam; PF00548; Peptidase_C3; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR Pfam; PF00073; Rhv; 2.
DR Pfam; PF00910; RNA_helicase; 1.
DR Pfam; PF08935; VP4_2; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51874; PCV_3C_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
DR PROSITE; PS51218; SF3_HELICASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral ion channel {ECO:0000256|ARBA:ARBA00023039};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022804};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT TRANSMEM 1036..1054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1502..1523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1203..1367
FT /note="SF3 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51218"
FT DOMAIN 1555..1744
FT /note="Peptidase C3"
FT /evidence="ECO:0000259|PROSITE:PS51874"
FT DOMAIN 1983..2095
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
SQ SEQUENCE 2207 AA; 247342 MW; 64646491FE7BD7EC CRC64;
MACLRIFSLK RKDKNHSYSP RGVELKYNLD FAFKPRPLAP LLRLEPSDTK TRRIECAEVE
YNSWYPNPLD PTSLVCDVEL EMLQFQGTGT SRMENGNTNN SGNTGVINYN FYSNSYTDAV
DLSGAMSSQE SNAAENAASG PTSLLKAGIN AAAKIGPLLA EPKFEEYRLS DRVDMIQKGT
STIISQSSVG SNTYADCPQF DVTSVADEGT TGGPAVSRFV TLKAKSWTPA QPVYAFQAAH
LPYALVAQDT PFKSLLSKHQ LMKCCWVAQV QVNTTRFHGG CLGVFAIPEF SVFSKLQGIT
STYTTNQDGV PSDIWDKFSA WHNPDEMYGA WYYHHVYDQT DKHWYKPEAK QYGGISPQSL
FCFPHQLINP RTNSSATLCL PFVDCGPITD VTVHCPWAIV VVVLRELTVA TGGTPSVDVN
VSLAPCDVEY HGLRQNSMYQ SPIPKFDIDA SKALFSSTQP YAAPPVYGKI PSSNSAFMPG
EFVDYVQLAQ IPSLVKSREI RVTSADKTGP IFHMPLRPTD TQTVNTMLGS VTRMFTQWRG
SIVIRCVFVG NQMQNCRILM AWTPQGFNTT HPTRIEDAMQ GHYVIYDTGV DSSADLVIPY
VAPYDFTPVR TPYTRTELPP AGTNNPVLVN TPYWSRGYVT IWQYTNLASP PGSPSQADFL
LFAFAGEDYV LKGPSNIAAS YQGNESSPLQ PAETGCDKAM TNDASNENPI SLPVESIGSS
RVDFFWGRYF HVATIPDVSN VKPQYLRLNI SDILFDPLIR QTLHATYLRC GLSIAVKVMP
ANTASTDCLD GLTINMLYVP PGSSWAINNT NETTPIEQAQ DSTQNYALPS FTWKPNQTPV
FTCSIPYVPF TTVLPTAYSG FESTFSIPKR NNQIPQDFGF GLLVLRPSMP PTHKLVVSVW
VKFNNMRLFC PRPGIHDDKS YSNDSTPIPG AETGQLSNAM TTMMLQGPGA TNFSLLKQAG
DVEENPGPSL SKLYQILKDP AVDALCEAYD ELKKFKEQAT NLLDSFSGES DNPWLNKFIK
YLGYAILAWK SLHDPMTAAA VCFIIGSDVT AFVVSKLAKH LKKFAKTDPP PVPKPRACKK
EGCCCGNKHN YPDELNPFSE SGFWSRFKKG HFQGPMQDVS SLINILKGAE WIYHQFEKVI
KWLKTWRTAE YEVSSDFLQT QMKDYPHYYR KYKECANNYR HPDRTEVAEY FRKMRKCAAH
VNPRLMGMFP EFDPSPPDPT RPEPVVVVLR GAPGQGKSVC SEMLARMLSY TLVGKSSYYA
FNSATKHFDG YKQQAVTIID DLGQDTSGED FRLFCQLVST TECIVPMADL PDKGMHFKSE
ILIANTNLPS FNPITVSDPA AIKRRIFLDL TVEANRAYTR PDGTLDLVRA LQPTGKESQS
PLLRQDHNIL YSDCVAFKHG KYTLSFLEVF DMIKRELQRR QNVSNSLTNL FTFQGPSDDS
WFTTFYKKWN LRAKENSEEK LILELIRYCH GSDMLKEYCQ LAAANKERKT DYWNMVRIIE
EILAALTLIL SLISIMIVMY QLFFQGPYEA SATKPAKPNR QSLLKLVEMQ GPKGQANMEM
ERTLMKKNII EMTYEKHNGK FQTTTVLFVR DRIFLINTHI LSSIKNFHYE NTEIPAASVQ
KVQAIFDGHP SDVTAVQFTV GRQYRDVTSN FINSLPNPGT PIVGLMKTEG SSYMWSGECL
PFKNTMNTYE GCVPHVLPYK AVTAHGYCGS VMVADAGVWK GICGIHSLGD GAIGAATVLS
RQHLLNLLEG FLEFQGKIYD VQKADFVYTP TKTSLKPTFV CVDPKLEPAA LSHHDPRLKD
PENFKAVILS KHVGDSLQLP WGIRWASYKY AERIRAMLPP DFLEPLSVRE AVEGIDGLDP
MDMDKSPGLP YVKKGLRRTD LWNPKTGPTI ELMAEINRYL DYNYDKHVFL TFLKDELRPK
EKVQAGKTRV IDVAGFGHAI VGRMLFGRLF AFFHKNPGWN TGSAVGVNPD LAWTQIFYTA
PSRNVLAMDY SGFDASHTSG MFCILKHFLT TLGYGTLQLS YIDSLCYSKH HWDDETYRLD
GGLPSGCSGT TIFNTIMNNI VARAAASYAA EGPVGILCYG DDILVSSPEK FPVSDWLEFY
SKTPYKVTAA DKSEQIDWRD ITQCTFLKRG FVLDGSLVRP VMDEQHLAEL LKWARPGTLQ
AKLLSIAQLA FHLPRQAYDR LMLPFEEAGY EIPCHERLNE EWREMFI
//