ID Y223_STAAM Reviewed; 252 AA.
AC Q99X00;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 01-MAY-2013, entry version 86.
DE RecName: Full=Uncharacterized response regulatory protein SAV0223;
GN OrderedLocusNames=SAV0223;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA Ogasawara N., Hayashi H., Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus
RT aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Probable member of the two-component regulatory system
CC SAV0224/SAV0223 (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC -!- PTM: Phosphorylated by SAV0224 (Potential).
CC -!- SIMILARITY: Contains 1 HTH araC/xylS-type DNA-binding domain.
CC -!- SIMILARITY: Contains 1 response regulatory domain.
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DR EMBL; BA000017; BAB56385.1; -; Genomic_DNA.
DR RefSeq; NP_370747.1; NC_002758.2.
DR ProteinModelPortal; Q99X00; -.
DR SMR; Q99X00; 2-241.
DR STRING; 158878.SAV0223; -.
DR EnsemblBacteria; BAB56385; BAB56385; SAV0223.
DR GeneID; 1120181; -.
DR KEGG; sav:SAV0223; -.
DR PATRIC; 19561056; VBIStaAur52173_0225.
DR eggNOG; COG4753; -.
DR HOGENOM; HOG000059795; -.
DR KO; K07720; -.
DR OMA; ICEYVIN; -.
DR ProtClustDB; CLSK884492; -.
DR BioCyc; SAUR158878:GJJ5-224-MONOMER; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.60; -; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeodomain-like.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR SUPFAM; SSF46689; Homeodomain_like; 2.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; FALSE_NEG.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1 252 Uncharacterized response regulatory
FT protein SAV0223.
FT /FTId=PRO_0000299112.
FT DOMAIN 3 118 Response regulatory.
FT DOMAIN 153 250 HTH araC/xylS-type.
FT DNA_BIND 170 191 H-T-H motif (By similarity).
FT DNA_BIND 217 240 H-T-H motif (By similarity).
FT MOD_RES 55 55 4-aspartylphosphate (By similarity).
SQ SEQUENCE 252 AA; 29575 MW; 16E88E45A3D52E2C CRC64;
MFKVVICDDE RIIREGLKQI IPWGDYHFNT IYTAKDGVEA LSLIQQHQPE LVITDIRMPR
KNGVDLLNDI ALLDCNVIIL SSYDDFEYMK AGIQHHVLDY LLKPVDHAQL EVILGRLVRT
LLEQQSQNGR SLASCHDAFQ PLLKVEYDDY YVNQIVDQIK QSYQTKVTVS DLIQHIDVSE
SYAMRTFKDH VGITIVDYLN RYRILQSLQL LDRHYKHYEI ADKVGFSEYK MFSYHFKKYL
QMSPSDYCKQ AK
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