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Database: UniProt
Entry: Q99X00
LinkDB: Q99X00
Original site: Q99X00 
ID   Y223_STAAM              Reviewed;         252 AA.
AC   Q99X00;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   01-OCT-2014, entry version 93.
DE   RecName: Full=Uncharacterized response regulatory protein SAV0223;
GN   OrderedLocusNames=SAV0223;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/S0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I.,
RA   Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K.,
RA   Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M.,
RA   Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M.,
RA   Ogasawara N., Hayashi H., Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus
RT   aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Probable member of the two-component regulatory system
CC       SAV0224/SAV0223. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by SAV0224. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 HTH araC/xylS-type DNA-binding domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00593}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00169}.
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DR   EMBL; BA000017; BAB56385.1; -; Genomic_DNA.
DR   RefSeq; NP_370747.1; NC_002758.2.
DR   ProteinModelPortal; Q99X00; -.
DR   SMR; Q99X00; 2-241.
DR   STRING; 158878.SAV0223; -.
DR   EnsemblBacteria; BAB56385; BAB56385; SAV0223.
DR   GeneID; 1120181; -.
DR   KEGG; sav:SAV0223; -.
DR   PATRIC; 19561056; VBIStaAur52173_0225.
DR   eggNOG; COG4753; -.
DR   HOGENOM; HOG000059795; -.
DR   KO; K07720; -.
DR   OMA; DHITHIR; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   PhylomeDB; Q99X00; -.
DR   BioCyc; SAUR158878:GJJ5-224-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.60; -; 2.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR009057; Homeodomain-like.
DR   InterPro; IPR018060; HTH_AraC.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   Pfam; PF12833; HTH_18; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   SMART; SM00342; HTH_ARAC; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA-binding; Phosphoprotein;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    252       Uncharacterized response regulatory
FT                                protein SAV0223.
FT                                /FTId=PRO_0000299112.
FT   DOMAIN        3    118       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   DOMAIN      153    250       HTH araC/xylS-type. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00593}.
FT   DNA_BIND    170    191       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00593}.
FT   DNA_BIND    217    240       H-T-H motif. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00593}.
FT   MOD_RES      55     55       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   252 AA;  29575 MW;  16E88E45A3D52E2C CRC64;
     MFKVVICDDE RIIREGLKQI IPWGDYHFNT IYTAKDGVEA LSLIQQHQPE LVITDIRMPR
     KNGVDLLNDI ALLDCNVIIL SSYDDFEYMK AGIQHHVLDY LLKPVDHAQL EVILGRLVRT
     LLEQQSQNGR SLASCHDAFQ PLLKVEYDDY YVNQIVDQIK QSYQTKVTVS DLIQHIDVSE
     SYAMRTFKDH VGITIVDYLN RYRILQSLQL LDRHYKHYEI ADKVGFSEYK MFSYHFKKYL
     QMSPSDYCKQ AK
//
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