ID Q9A0U5_STRP1 Unreviewed; 411 AA.
AC Q9A0U5; Q48ZU0;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE RecName: Full=Aminoacyltransferase FemA {ECO:0000256|ARBA:ARBA00016236};
DE EC=2.3.2.17 {ECO:0000256|ARBA:ARBA00012466};
DE AltName: Full=Factor essential for expression of methicillin resistance A {ECO:0000256|ARBA:ARBA00032233};
DE AltName: Full=N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N6-glycyl)-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase {ECO:0000256|ARBA:ARBA00030706};
GN Name=murN {ECO:0000313|EMBL:AAK33588.1};
GN OrderedLocusNames=SPy_0615 {ECO:0000313|EMBL:AAK33588.1};
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK33588.1, ECO:0000313|Proteomes:UP000000750};
RN [1] {ECO:0000313|EMBL:AAK33588.1, ECO:0000313|Proteomes:UP000000750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1
RC {ECO:0000313|Proteomes:UP000000750};
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-
CC (N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate +
CC 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-
CC (N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-
CC GlcNAc + 2 tRNA(Gly); Xref=Rhea:RHEA:30439, Rhea:RHEA-COMP:9664,
CC Rhea:RHEA-COMP:9683, ChEBI:CHEBI:15378, ChEBI:CHEBI:62234,
CC ChEBI:CHEBI:62235, ChEBI:CHEBI:78442, ChEBI:CHEBI:78522; EC=2.3.2.17;
CC Evidence={ECO:0000256|ARBA:ARBA00023962};
CC -!- SIMILARITY: Belongs to the FemABX family.
CC {ECO:0000256|ARBA:ARBA00009943}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00008694}.
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DR EMBL; AE004092; AAK33588.1; -; Genomic_DNA.
DR RefSeq; NP_268867.1; NC_002737.2.
DR AlphaFoldDB; Q9A0U5; -.
DR PaxDb; 1314-HKU360_00521; -.
DR KEGG; spy:SPy_0615; -.
DR PATRIC; fig|160490.10.peg.525; -.
DR HOGENOM; CLU_048411_1_0_9; -.
DR OMA; YNFLGIM; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0016755; F:aminoacyltransferase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.90; -; 1.
DR Gene3D; 3.40.630.30; -; 2.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR003447; FEMABX.
DR InterPro; IPR010978; tRNA-bd_arm.
DR PANTHER; PTHR36174:SF2; AMINOACYLTRANSFERASE FEMA; 1.
DR PANTHER; PTHR36174; LIPID II:GLYCINE GLYCYLTRANSFERASE; 1.
DR Pfam; PF02388; FemAB; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 2.
DR SUPFAM; SSF46589; tRNA-binding arm; 1.
DR PROSITE; PS51191; FEMABX; 1.
PE 3: Inferred from homology;
KW Cell shape {ECO:0000256|ARBA:ARBA00022960};
KW Cell wall biogenesis/degradation {ECO:0000256|ARBA:ARBA00023316};
KW Peptidoglycan synthesis {ECO:0000256|ARBA:ARBA00022984};
KW Reference proteome {ECO:0000313|Proteomes:UP000000750}.
SQ SEQUENCE 411 AA; 47528 MW; 796733F6B309F6AF CRC64;
MALIEISQEQ FDHYCHSLVH HSFIQTSEMA SLMAKRGAKP QFLGLEKDGE LKVAAMVFSQ
KVAGGWRMEL NAGPNTNHPE ELEHFYTQLK DYAKQKDVIE LILKPYDNYQ SFDTDGIPIS
RPNTDLISLL TALGYKHDGL KTGYPEGEPV WHYVKKLEGI DSSRLTRSFS KKGKALIKKA
NTFGIKLRQL KRDELHHFKE ITEATSDRRD YLDKSLSYYQ DFYDSFGDSC EFMVATLNFE
DYLNNLKQRQ LQLATSINKV KGDLGKNPHS EKKQNRLKEL SSQFETFQVR ISEALHFLEE
YGTKDVFLAG SLFIYTEQEA VYLFSGSYPK FNKFYSPALL QEHAMLKAIH KGIKQYNFLG
ITGKFDGSDG VLRFKQNFNG FILQKPGTFR CYPFPIKYHF IRLAKKLLNR Y
//
