ID Q9ADL6_SORCE Unreviewed; 6315 AA.
AC Q9ADL6;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Soraphen polyketide synthase A {ECO:0000313|EMBL:AAK19883.1};
GN Name=sorA {ECO:0000313|EMBL:AAK19883.1};
OS Sorangium cellulosum (Polyangium cellulosum).
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae; Sorangium.
OX NCBI_TaxID=56 {ECO:0000313|EMBL:AAK19883.1};
RN [1] {ECO:0000313|EMBL:AAK19883.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=So ce26 {ECO:0000313|EMBL:AAK19883.1};
RA Beck J.J.;
RL Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAK19883.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=So ce26 {ECO:0000313|EMBL:AAK19883.1};
RA Ligon J.M., Hill S., Beck J., Zirkle R., Molnar I., Zawodny J., Money S.,
RA Schupp T.;
RL Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAK19883.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=So ce26 {ECO:0000313|EMBL:AAK19883.1};
RX PubMed=12039053; DOI=10.1016/S0378-1119(02)00396-7;
RA Ligon J., Hill S., Beck J., Zirkle R., Molnar I., Zawodny J., Money S.,
RA Schupp T.;
RT "Characterization of the biosynthetic gene cluster for the antifungal
RT polyketide soraphen A from Sorangium cellulosum So ce26.";
RL Gene 285:257-267(2002).
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DR EMBL; U24241; AAK19883.1; -; Genomic_DNA.
DR KEGG; ag:AAK19883; -.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 2.
DR CDD; cd08952; KR_1_SDR_x; 1.
DR CDD; cd08956; KR_3_FAS_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 3.30.70.3290; -; 4.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 3.40.50.11460; -; 2.
DR Gene3D; 6.10.140.1830; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 4.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR041618; PKS_DE.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 4.
DR Pfam; PF08240; ADH_N; 2.
DR Pfam; PF13602; ADH_zinc_N_2; 2.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 3.
DR Pfam; PF18369; PKS_DE; 1.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 4.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00827; PKS_AT; 4.
DR SMART; SM00826; PKS_DH; 2.
DR SMART; SM00829; PKS_ER; 2.
DR SMART; SM00822; PKS_KR; 3.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 2.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 4.
DR SUPFAM; SSF50129; GroES-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 8.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 4.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 2.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 13..90
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 110..535
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1990..2065
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2092..2518
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 4083..4158
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4176..4597
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 6157..6232
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 3090..3133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6315 AA; 671327 MW; 7B3FB977006C12FE CRC64;
MTKEYTRPQS APLTEGDLLT LIVAHLAERL RMDARFIDVH EPFSRHGLDS RGAVDLVVDL
RTALGRPLSP VVVWQHPTPD ALARHLAGGA DAREGQARAD SAYERPGAPN EPIAIVGMAC
RFPGAPDVDS YWRLLSGGVD AVTEVPAGRW DMDAFYDRDP RSLGDVSTLR GGFIDDVDRF
DAMFFGISPR EAVSMDPQQR LMLELAWEAL EDAGIVAERL KESLTGVFFG CIWDDYVTLI
HQRGRGAIAQ HTVTGNHRSI IANRVSYTLD LRGPSMTVDS ACSSALVTIH MACESLRSGE
STLALAGGVN LNIAPESTIG VHKFGGLSPD GRCFTFDARA NGYVRGEGGG VVVLKRLSSA
IADGDPIICV IRGSAVNNDG ASNGLTGPNP LAQEAVLRTA YERAGVNPAD VQYVELHGTG
TQLGDPVEAS ALGAVLGKRR PAERPLLVGS AKTNVGHLEG AAGIVGLLKA ALCLKHKQLA
PNLNFETPNP HIPFAELNLK VQGALGPWPD MDRPLVCGVS SFGLGGTNAH VVLSEWASLE
AELHPLAAES PEALREEVQR RLLTMTSLVG RAPLSFLCGR SAAQRSAKEH RLAVTARSFE
ELKQRLLGFL EHEKHVSVSA GRVDLGAAPK VVFVFAGQGA QWFGMGRALL QREPVFRTTI
EQCSSFIQQN LGWSLLDELM TDRESSRLDE IDVSLPAIIS IEIALAAQWR AWGVEPAFVV
GHSTGEIAAA HVAGVLSIED AMRTICAYGR IIRKLRGKGG MGLVALSWED AGKELTGYEG
RLFRAIEHSA DSTVLAGEPD ALDALLQALE RKNVFCRRVA MDVAPHCPQV DCLRDELFDA
LREVRPNKAQ IPIVSEVTGT ALDGERFDAS HWVRNFGDPA LFSTAIDHLL QEGFDIFLEL
TPHPLALPAI ESNLRRSGRR GVVLPSLRRN EDERGVMLDT LGVLYVRGAP VRWDNVYPAA
FESMPLPSTA GGGKPLPPMP LLISARTDAA LAAQAARLRA HLDSHLDLEL VDVAYSLAAT
RTHFERRAVV VARDRAGILD GLDALAHGGS AALLGRSAAH GKLAILFTGQ GSQRPTMGRA
LYDAFPVFRG ALDAAAAHLD RDLDRPLRDV LFAPDGSEQA ARLDQTAFTQ PALFALEVAL
FELLQSFGLK PALLLGHSIG ELVAAHVAGV LSLQDACTLV AARAKLMQAL PQGGAMVTLQ
ASEQEARDLL QAAEGRVSLA AVNGHLSTVV AGDEDAVLKI ARQVEALGRK ATRLRVSHAF
HSPHMDGMLD DFRRVAQGLT FHPARIPIIS NVTGARATDQ ELASPETWVR HVRDTVRFLD
GVRTLHAEGA RAFLELGPHP VLSALAQDAL GHDEGPSPCA FLPTLRKGRD DAEAFTAALG
ALHAAGLTPD WNAFFAPFAP CKVPLPTYTF QRERFWLDAS TAHAASATPA AALEGRFWQA
VESGDIDTLS SELHVDGDEQ RAALALVLPT LSSFRHKRQE QSTVDAWRYR VTWKPLTTAA
TPADLAGTWL LVVPSALGDD ALLATLTEAL TRRGARVLAL RVSDIHIGRS ALVEHLREAL
AETAPLRGVL SLLALDEHRL ADRSALPAGL ALSLALVQGL DDLAIEAPLW LFTRGAVSIG
HSDPITHPTQ AMIWGLGRVV GLEHPERWGG LVDVSAGVDE SAVGRLLPAL AQRHDEDQLA
LRPAGLYARR IVRAPLGDAP PAREFRPRGT ILITGGTGAL GAHVARWLAR QGAEHLILIS
RRGAEAPGAS ELHAELNALG VRTTLAACDV ADRSALQALL DSIPSDCPLT AVFHTAGARD
DGLIGDMTPE RIERVLAPKL DSALHLHELT KNSALDAFVL YASLSGVLGN PGQANYAAAN
AFLDALAEHR RSLGLTATSV AWGGWGGGGM ATERVAAQLQ QRGLLQMAPS LALAALAQAL
QQDETTITVA DIDWSRFAPA FSVARQRPLL RDLPEAQRAL QASEGASSEH GPATGLLDEL
RSRSESEQLD LLATLVRGET ATVLGHAEAS HVDPDKGFMD LGLDSLMTVE LRRRLQKATG
VKLPPTLAFD HPSPHRVAFF LRDSLARAFG TRLSAERDGA ALPAPGATSD SDEPIAIVGM
ALRLPGGIGD VDALWDFLHQ GRDAVEPIPP TRWDAGALYD PDPDAKAKSY VRHAAMLDQV
DLFDPGFFGI SPREAKHIDP QHRLLLEAAW QALEEAGIVP STLKDSPTGV FVGIGASEYA
PREPGAEDSE AYIVQGTYAS FAAGRLAFTL GLQGPALSVD TACSSSLVAL HLACQALRRD
ECNLALAAGA SVMVSPETFV LLSRLRALAP DGRSKTFSAS ADGYGRGEGV IVLALERLRD
ALAQGRRVLA VVRGTAVNHD GASSGITAPN GTSQKKVLRA ALHDARIAPA DVDVVECHGT
GTSLGDPIEV QALAAVYGEG RSAEKPLFLG AVKTNVGHLE AAAGLAGVAK IVASLLHNAL
PPTLHTTPRN PLIAWDALAV AVVDATRPWV RHADGRPRRA GVSAFGLSGT NAHVILEEAP
AIARVEPAAS QPASEPLPAA WPVLLSAKSE AAVRAQAKRL RDHLLAKSEL ALADVAYSLA
TTRAHFEQRA ALLVKGRDEL LSALDSLAQG HSAAVLGRSG APGKLAVLFT GQGSQRPTMG
RALYDAFPVF RDALDTVAAH LDRDLDRPLR DVLFAPDGSE QAARLDQTAF TQPALFALEV
ALFQLLQSFG LKPALLLGHS IGELVAAHVA GVLSLQDACT LVAARAKLMQ ALPQGGAMVT
LRASEEEVRD LLQPYDGRAS LAALNGPLST VVAGDEDAVV EIARQAEALG RKTTRLRVSH
AFHSPHMDGM LDDFRRVAQS LTYHPARIPI ISNVTGARAT DHELASPDYW VRHVRHTVRF
LDGVRALHAE GARVFLELGP HAVLSALAQD ALGQDEGTSP CAFLPTLRKG RDDAEAFTAA
LGALHAAGLT PDWSAFFAPF APRKVSLPTY AFQRERFWLD ASKAHAADVA SAGLTSTDHP
LLGAGVPLAD RDGFLFTGRL SLSEHPWLAD HVVFGTPILP GTAFLELALF VAGRVGLDTV
EELTLETPLA LPSEGALLVQ VSVGPLDDAG RRPLSLHSRP QGAPQDAPWT RHASGSLAPA
TPSPSFDLHD WPPSGATQVD TQGLYATLES AGLAYGPQFQ GLRSVWRRGD ELFAEAQLPD
AAKKDAARFA LHPALLDSAL HALALDDERA PGVALPFSWG GVSLRAVGAT TLRVRFHRPK
GETAGSLVLA DAAGGPIASV QALATRITSA EQLRTPGASH HDALFRVDWS ELPSPTSPSG
APSAVLLGIG GLDLAPEVPL ARVADLAALQ SALDQGASPP GLVVVPFMAR TADDLIQSAH
SITARALALL QAWLADERLA SSRLVLLTRR AIAARADEDV KDLAHAPLWG LARSAQSEHP
ELPLFLVDLD LSEASQHTLL AALETGERHS RLRNGKPFIP RLANARSKDE LIAPDASNWR
LHIPTKGNFD ALTLVDAPLA RAPLAHGQVR VAVHAAAFNF RDVLDTLGLY PGDAGPLGGE
GAGIVTEVGP GVSRYTVGDR VMGIFGAACG PTAIADARMI CPIPHAWSFA QAASVPIIYL
TAYYGLVDLG HLKPNQRVLI HAAAGGVGTA AVQLARHLGA EVFATASAGK WSALRALGFD
DAHLASSRDL DFEQHFLRST HGRGVDVVLD CLAREFVDAS LRLMPSGGRF VEMGKTDIRE
PDAVGVAYPG VVYRAFDLIE AGPDRIEQML AELLSLFERG ALRPPPITSW DIRHAPQAFR
ALAQARHVGK FVLTIPRPID PEGTVLITGG TGTLGALVAR HLVARHGAKH LLLTSRQGAH
APGAEASRTE LEALGASVTL RACDAADPRA LQALLDSIPS AHPLTAVVHA AGALDDGLLG
AMSPERIDRV FAPKLDAAWH LHELTQDKPL AAFVLFSSAA GVLGSPGQSN YAAANAFLDA
LAHHRRAHGL PASSLAWGYW AERSRMTEHL SAADVSRMRR AGVRPLATDE ALSLFDAALL
RPEPALVPAR FDVNALGANA DEVPPLFQRL VRARVARKAA SNTALASSLS QRLSSLPPAE
SERFLLDLVR TEAATVLGLA SFESLDPHRP LQELGLDSLI ALELRGRLAA ATGLRLQPTL
LFDYPTPAAL SRFFTTQFFG ETTDRPAAPL TPAGSEDPIA IVSMSCRFPG DVRTPEDLWK
LLLDGKDAIS SFPQNRGWSL DALDAPGRFP VREGGFVYDA DAFDPAFFGI SPREALAIDP
QQRLLLEISW EALERAGIDP ASLQGSQSGV FVGIIHNDYG AWLMNGTDEH KGFAATGSTA
SVASGRIAYT FGFQGPAISV DTACSSSLVA VHLACQALRH GECSLALAGG VTVLATPAVF
VAFDSESAGA PDGRCKAFSA EANGAGWAEG AGMLLLERLS DAVRNGHPVL AVLRGSAVNQ
DGRSQGLTAP NGPAQERVIR QALDSARLTP KDIDAVEAHG TGTTLGDPIE AQAILATYGE
SHSQDSPLWL GSLKSNMGHT QAAAGVGSVI KMVLALQHGL LPKTLHAKNP SPHIDWSPGT
VKLLDEPVVW KTNGHPRRAG VSSFGFSGTN AHVILEEAPA IARAESAAAQ PASEPLPAAW
PVLLSAKSEA ALRAQAARLR DHLQAHPDLE LADVAYSLAT TRAHFERRAV VVAKDRDEAT
FALDAFEQGS PAHHVAHGEA RVAGKLVFVF PGQGSQWPGM AQQLLTTSDA FRAQVEACAR
AFAPHLGWSL LAVLRGDEGA PSLERIEVVQ PALFTVMVSL AALWRSRGIE PDAVVGHSQG
ELAAAYVAGA LSLDDAAKVV ARRSRLLSTL SGQGAMAAVE RPPAALEPYL ARFGRRLSIA
AINSPSATTV SGEPDAIDHL LRLLKAEQIF ALKLRVDVAS HGAQIEGMRE QLLEELREIE
PRESRIPFYS TVRGEKLAGT ELGAAYWYDN LLRPVRFADA TQLLLDDAHR FFVEVSPHPV
LMLPLEETLE ASGLPTAVLG SLWQDEGDLS RFLASLGELY ARGYAVDWRA FFEPLRPRRV
ALPTYAFQRE RFWLDAPTAH ADVASAGLTS ADHPLLGAAV RLADTDAFLF TGRLSLQSHP
WLAEHAAFGI PILPGTAFLE LALLAADRVG LDTVEEVTLE APLALPSQGT ILIQISVGPM
DEAGRRSLSL HGRTEDAPQD APWTRHASGS LAKAAPSLSF DLHEWAPPGG TPVDTQGSYA
GLESGGLAYG PQFQGLRSVW KRGDELFAEA KLPDAGAKDA ARFALHPALF DSALHALVLE
DERTPGVALP FSWRGVSLRS VGATTLRVRF HRPNGKSSVS LLLGDAAGEP LASVQALATR
ITSQEQLRTQ GASLHDALFR VVWRDLPSPT SLSEAPKGVL LETGGLDLAL QASLARYDGL
AALRSALDQG ASPPGLVVVP FIDSPSGDLI ESAHNSTARA LALLQAWLDD ERLASSRLVL
LTRQAIATHP DEDVLDLPHA PLWGLVRTAQ SEHPELPLFL VDLDLGQASE RALLGALDTG
ERQLALRHGK CLVPRLVNAR STEALIAPNV STWSLHIPTK GTFDSLALVD APLARAPLAQ
GQVRVAVHAA GLNFRDVLNT LGMLPDNAGP LGGEGAGIVT EVGPGVSRYT VGDRVMGIFR
GGFGPTVVAD ARMICPIPDA WSFVQAASVP VVFLTAYYGL VDVGHLKPNQ RVLIHAAAGG
VGTAAVQLAR HLGAEVFATA SPGKWDALRA LGFDDAHLAS SRDLEFEQHF LRSTRGRGMD
VVLNALAREF VDASLRLLPS GGSFVEMGKT DIREPDAVGL AYPGVVYRAF DLLEAGPDRI
QEMLAELLDL FERGVLRPPP ITSWDIRHAP QAFRALAQAR HIGKFVLTVP RPIDPEGTIL
VTGGTGTLGA LIARHLVANR GAKHLLLTSR KGASAPGAEA LRSELEALGA AVTLARCDAA
DPRALQALLD SIPSAHPLTA VVHAAGALDD GLISAMSPER IDRVFAPKLD AAWHLHQLTQ
DKPLAAFVLF SSASGVLGGM GQSNYAAANA FLDALAHHRR VHGLPASSLA WGHWAERSGM
TRHLSGVDTA RMRRAGLRSI ASDEGLALFD MALGRPEPAL VPARFDMNAL GAKADGLPSM
FQGLVRARVA RKVASNNALA ASLTQRLASL PPTDRERMLL DLVRAEAAIV LGLASFESLD
PRRPLQELGL DSLMAIELRN RLAAATGLRL QATLLFDHPT PAALATLLLG KLLQHEAADP
RPLAAELDRL EATLSAIAVD AQARPKIILR LQSWLSKWSD AQAADAGPIL GKDFKSATKE
ELFAAFDEAF GGLGK
//
