ID Q9ADP6_STRCO Unreviewed; 1463 AA.
AC Q9ADP6;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Bifunctional protein (Histidine kinase and regulator) {ECO:0000313|EMBL:CAC32349.1};
GN OrderedLocusNames=SCO4009 {ECO:0000313|EMBL:CAC32349.1};
GN ORFNames=2SC10A7.13c {ECO:0000313|EMBL:CAC32349.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC32349.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC32349.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
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DR EMBL; AL939118; CAC32349.1; -; Genomic_DNA.
DR RefSeq; NP_628191.1; NC_003888.3.
DR RefSeq; WP_011029379.1; NZ_VNID01000032.1.
DR STRING; 100226.gene:17761637; -.
DR PaxDb; 100226-SCO4009; -.
DR PATRIC; fig|100226.15.peg.4072; -.
DR eggNOG; COG0642; Bacteria.
DR eggNOG; COG0745; Bacteria.
DR eggNOG; COG3290; Bacteria.
DR HOGENOM; CLU_002345_0_0_11; -.
DR InParanoid; Q9ADP6; -.
DR OrthoDB; 7053013at2; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00130; PAS; 2.
DR CDD; cd00156; REC; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00989; PAS; 2.
DR SMART; SM00091; PAS; 2.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; Kinase {ECO:0000313|EMBL:CAC32349.1};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transferase {ECO:0000313|EMBL:CAC32349.1}.
FT DOMAIN 145..198
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1338..1457
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 615..717
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 266..323
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 793..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 920..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1010..1031
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1056
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1068..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1160
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1387
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1463 AA; 149841 MW; 894D30968DD98D85 CRC64;
MSSRPSRGTA RLAAILDALP DALVLVNANG TVVNANTIAL EAFETPGTAL VGRGLLDLLP
HFDSRLIPGS MRRPDHIDPR ARTKPTRMVA RRTDGSEFPV EVTSANLETG QQAYDTYGYT
GDELLMLVVR DLSGTVDTEA ELARSQRQTE MILRAASEGV VGTDTDGRIV LVNPAAAQIL
GYRAGELGGR ELHTLVLHSR ADGSPFPYDE SPLADTLRSG RKHRVRGQVL FAKSGDQLPV
DLTTAPVRDG DQLVGAVMTF TDRRPYDALV EEHEEAERRH AEELERLAEE HAAELTGLRQ
RHAAELEELK EQHAEELAAD ADRYAALGER EKDRYEAIAG RHEQLLTLLG DSLRGPLDEL
RRELAALASD DAGQLWPEAN QVLHHLSAGY SRITTLIDNV LGYQRLDVGN EQVARTKVML
DAVVAAGVDG AVELIGPGRV QFAVHAPPIE AEVDPRLLAT ALAHLVADVA GVDATGNSPV
SATGGYLDNT VVVAAAQRGE VVRIEVRGPY AGGDPVHEPI VRGIVRAHGG VLQTHDVPGM
SGSAFVLEVP IGGGAGAVTA QGAELAQIAP AVPDAPADSA GGVGAQGTVA VREPASGGGR
RRARRASVDA FLESGVAGAP GDAGAGPEAE NSAPTGRRRR RAAQAGAQAG AGVEAGAGAE
ISAQGQGQGQ GQGGDVPAPL PVPAQAGPGA GAGTGGTGRR RGRPAETSGA EVAGVPQAAL
GGVSEGAVVM AGEHGGGAAA SNTGLGGTVP PQGVPAPTGR RAGQDGGEQH ALPPALPAQA
GESNPADPAD PETADRPTGR RRRALASANE RAAAQEAAPR QVFALPPAGA DADADRPSEG
AATAPGRVQE PGQVQPGRVR VPGPAAPGDA VPDEGRHDAV SHDQSEDHTP PQPHPAEAPT
GRRRRAGAAR PADEPVPGQA QGQGQGQGQG QGQGQGQAQS APAQGIPVQG APPVQGAPVP
APAATGTEAQ APRPAESGAD TAAPAAPGQP APAPQPWPAA ADIQGAGAPV PPGSPVPPGA
APAPAAPAAP AAPQGVPATT PSRGTPLPPE NAPAPRAAQP LPAEASAPVD PNSTQGRAIS
VRTLGQGVPF NRQAVQVQQP SATPAPHQPG GGGRRRKLGT PPDPAAGGTA PSARPHPPAE
QPPGAQPKKQ APPQPPRQSP DQPSLAGGQG RLAPVTEGAG RSYAIGAPDR NAAEGPEPLD
GPGGAVEVAD PPRPQPMDDE LPPEPLDNPR RLLVWPAPDV STQQALSDRG YRPVIVNSRE
EVDAQIAAFP AALFVDPLTG PITRTALQSL RQAAVAAEVP VLVTAGLGQA SRDAAYGADP
AVLLKALAPR DSEQHPPRVL LIEEHAEIAL ALTSTLERRG MQVARAASDA DAVTLAGQFR
PNLVVMDLMR VQRRQERSAG IVDWLRANGQ LNRTPLVVYT AAVDQDDLPR LASGETVLFL
AERSTSAEVQ SRIVELLSRI GTN
//
