ID Q9AZ40_BPHK6 Unreviewed; 385 AA.
AC Q9AZ40;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Integrase {ECO:0000256|ARBA:ARBA00016082};
GN Name=int {ECO:0000313|EMBL:AAK28849.1};
OS Enterobacteria phage HK620 (Bacteriophage HK620).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Lederbergvirus; Lederbergvirus HK620.
OX NCBI_TaxID=155148 {ECO:0000313|EMBL:AAK28849.1, ECO:0000313|Proteomes:UP000000725};
OH NCBI_TaxID=562; Escherichia coli.
RN [1] {ECO:0000313|EMBL:AAK28849.1, ECO:0000313|Proteomes:UP000000725}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11518522; DOI=10.1006/jmbi.2001.4868;
RA Clark A.J., Inwood W., Cloutier T., Dhillon T.S.;
RT "Nucleotide sequence of coliphage HK620 and the evolution of lambdoid
RT phages.";
RL J. Mol. Biol. 311:657-679(2001).
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
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DR EMBL; AF335538; AAK28849.1; -; Genomic_DNA.
DR RefSeq; NP_112034.1; NC_002730.1.
DR GeneID; 921017; -.
DR KEGG; vg:921017; -.
DR OrthoDB; 3050at10239; -.
DR Proteomes; UP000000725; Genome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd00801; INT_P4_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 3.30.160.390; Integrase, DNA-binding domain; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR038488; Integrase_DNA-bd_sf.
DR InterPro; IPR025166; Integrase_DNA_bind_dom.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR Pfam; PF13356; Arm-DNA-bind_3; 1.
DR Pfam; PF14659; Phage_int_SAM_3; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248}; Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000000725};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 91..172
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 195..373
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 385 AA; 44100 MW; 2588C29BD25BD37B CRC64;
MLTVKQIEAA KPKEKPYRLL DSNGLYLYVP VSGKKVWQLR YKIDGKEKIL TVGKYPLMTL
QEARDKAWAA RKDISVGIDP VKAKKAPSNN NSFSAIYKEW YEHKKQVWSV GYATELAKMF
DDDILPIIGG LEIQDIEPMQ LLEVIRRFED RGAMERANKA RRRCGEVFRY AIVTGRAKYN
PAPDLADAMK GYRKKNFPFL PADQIPAFNK ALATFSGSIV SLIATKILRY TALRTKELRS
MQWKNVDFEN RIITIDASVM KGRKIHVVPM SDQVVELLTT LSSITKPVSE FVFAGRNDKK
KPICENAVLL VIKQIGYEGL ESGHGFRHEF STIMNEHEWP ADAIEVQLAH ANGGSVRGIY
NHAQYLDKRR EMMQWWADWL DEKVE
//
