ID Q9BJD5_STRPU Unreviewed; 933 AA.
AC Q9BJD5;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Toll-like receptor Tlr1.2 {ECO:0000313|EMBL:AAK25762.1};
OS Strongylocentrotus purpuratus (Purple sea urchin).
OC Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC Euechinoidea; Echinacea; Camarodonta; Echinidea; Strongylocentrotidae;
OC Strongylocentrotus.
OX NCBI_TaxID=7668 {ECO:0000313|EMBL:AAK25762.1};
RN [1] {ECO:0000313|EMBL:AAK25762.1}
RP NUCLEOTIDE SEQUENCE.
RA Pancer Z.;
RT "Sea Urchin coelomocyte Toll-like receptors.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000007110}
RP NUCLEOTIDE SEQUENCE.
RA Murali S., Liu Y., Vee V., English A., Wang M., Skinner E., Han Y.,
RA Muzny D.M., Worley K.C., Gibbs R.A.;
RT "Genome sequencing for Strongylocentrotus purpuratus.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblMetazoa:NP_999671}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JAN-2021) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. AMIGO family.
CC {ECO:0000256|ARBA:ARBA00005670}.
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DR EMBL; AF335483; AAK25762.1; -; mRNA.
DR RefSeq; NP_999671.1; NM_214506.1.
DR AlphaFoldDB; Q9BJD5; -.
DR EnsemblMetazoa; NM_214506; NP_999671; GeneID_373264.
DR GeneID; 373264; -.
DR KEGG; spu:373264; -.
DR CTD; 373264; -.
DR InParanoid; Q9BJD5; -.
DR OrthoDB; 384316at2759; -.
DR Proteomes; UP000007110; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR031283; AMIGO.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24368; AMPHOTERIN-INDUCED PROTEIN; 1.
DR PANTHER; PTHR24368:SF210; SURFACE ANTIGEN BSPA-LIKE; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:AAK25762.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007110};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..933
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033977907"
FT TRANSMEM 725..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 778..920
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 933 AA; 107287 MW; B54C13D509E19E78 CRC64;
MAFIRQAPFL RCLPLVLLCI LTPTLIQTIH QDAMLTSSMK CHYDAEQKEA DCSDRGLDSI
PQNLPDDIEE LDLKFNKITF ILSSSFMRYP LIQVLDFSSN DIRMIESASF YPLKELNRLD
LPFNHNLVFP ATDLFRWSRN LSILKLYGSN LKLLPNDTLK WSPSVESIYL RFNKLTFVNM
SLCGRAKKIS LAYNKIEHLT AESFIIGCQS DYIDLTGNPI KSVDPNVIAS LRVRSLVLGE
YPLTLEVLKD TFIGICRSEI VELTINGANF TVLPRDFFSP LRNCSPPVLK FTGNNLQSLS
QNVFSNLTRL VELDLSHNEI QALSPYVFSN LTRLVELDLS FNEIQSLSPY VFSNLTRLVE
LDLSQNKIIT VEPVFYQGMR GLKVLNLNFN QIKYINPNTD EWTLDLNELY LRSNSLTEIS
EFAFFGLRNL TLLDLSFNKD LIVLNITSSS KLTGIQTIAL NFCNFCDMDI FQPVAPNLTT
LFMNNMIAEM IMMAPGITFE DSQGLENLEI RNSGLSNFNI WDEILNTSLF DGLSNLITLD
LSQNYFDFYF PDDFPARIFK QLSALQNLSL EACHISCLHP LAFTGLESLR VLNLSGNVIQ
QLNFDIFKML DQVTIIDLHD NLLAYLDEQL FSNNPRLTTL LLSNNKLTLL NQKTFEPIES
SLLSFDLSLN PIDCNCDLRW FRDWMSGHID VIDKNRTICS SASLQPLREK PLLDFDPNKL
CGLNIGLVVM TPLAGIFLGV IVAIFYHNRL QLKYKLFLLK LMVIGYKEMR DARDHNDYEF
DLNIIFYEDD EEWVRQQLQP ALEERLPQFQ RNVFGDQDLI LGMHYLDAVD YVVSHSYKTL
ILLSRAAVHD RWFMLKLRTA MDHVSDTQTE FVVVVFLEDF PDEDIPFLAR LYLSDGRPYQ
HWTEDVGGHV FFWNALVKNL TINLRTNDFI PNE
//
