ID Q9BK19_CAEEL Unreviewed; 436 AA.
AC Q9BK19;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Ionotropic glutamate receptor GLR-7 {ECO:0000313|EMBL:AAK01099.1};
DE Flags: Fragment;
GN Name=glr-7 {ECO:0000313|EMBL:AAK01099.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:AAK01099.1};
RN [1] {ECO:0000313|EMBL:AAK01099.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11222641;
RA Brockie P.J., Madsen D.M., Zheng Y., Mellem J., Maricq A.V.;
RT "Differential expression of glutamate receptor subunits in the nervous
RT system of Caenorhabditis elegans and their regulation by the homeodomain
RT protein UNC-42.";
RL J. Neurosci. 21:1510-1522(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; AF318611; AAK01099.1; -; mRNA.
DR AlphaFoldDB; Q9BK19; -.
DR UCSC; C43H6.9; c. elegans.
DR HOGENOM; CLU_007257_7_1_1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13717; PBP2_iGluR_putative; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF411; IONOTROPIC RECEPTOR 25A; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AAK01099.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 121..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..393
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 8..67
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAK01099.1"
FT NON_TER 436
FT /evidence="ECO:0000313|EMBL:AAK01099.1"
SQ SEQUENCE 436 AA; 49408 MW; 5ECEBC58596193AA CRC64;
VVTLIQPPFV QRTGDPDTPY EGYCIDLINM IQVEVNFTYT IYEVEDGSFG TMDDNGNWNG
LIGALVSGSA DIALAPLSVM AERENDVDFT VPYYDLVGTT ILMKKADVEY SLFKFMKVLE
WPVWLCIVAA YLFTSILLWI FDRFSPYSFT NNKERYQNDI EKRQFSLKEC LWFCMTSLTP
QGGGEAPKNI SGRLVAATWW LFGFIIIASY TANLAAFLTV SRLEQPISSL DDLAKQYKIE
YAPIKGSASE TYFRRMAEIE ETFYNMWKEM SLNESMSPRD RAKLAVWDYP VSDKFTNMWR
YMQESKLPVN MDTAVDRVLN SVDGFAFIGD ATEIKYAALT NCNLQQVGTE FSRKPYAIAV
QSGHILKDKI SSAILMLLNE RRLETLKEKW WTDNPNKVSC PDSSDESDGI SIQNIGGVFI
VILAGIALSI VTLAFE
//
