ID ZN416_HUMAN Reviewed; 594 AA.
AC Q9BWM5; Q9NWW8;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 01-MAY-2013, entry version 94.
DE RecName: Full=Zinc finger protein 416;
GN Name=ZNF416;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC Catarrhini; Hominidae; Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-483.
RC TISSUE=Carcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 12 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91257.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
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DR EMBL; BC000130; AAH00130.1; -; mRNA.
DR EMBL; AK000564; BAA91257.1; ALT_SEQ; mRNA.
DR IPI; IPI00020818; -.
DR RefSeq; NP_060349.1; NM_017879.1.
DR UniGene; Hs.247711; -.
DR ProteinModelPortal; Q9BWM5; -.
DR PhosphoSite; Q9BWM5; -.
DR DMDM; 74762716; -.
DR PaxDb; Q9BWM5; -.
DR PRIDE; Q9BWM5; -.
DR DNASU; 55659; -.
DR Ensembl; ENST00000196489; ENSP00000196489; ENSG00000083817.
DR GeneID; 55659; -.
DR KEGG; hsa:55659; -.
DR UCSC; uc002qpf.3; human.
DR CTD; 55659; -.
DR GeneCards; GC19M058082; -.
DR HGNC; HGNC:20645; ZNF416.
DR neXtProt; NX_Q9BWM5; -.
DR PharmGKB; PA134905500; -.
DR eggNOG; COG5048; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q9BWM5; -.
DR KO; K09228; -.
DR OMA; YTLVEHQ; -.
DR OrthoDB; EOG4XGZZM; -.
DR PhylomeDB; Q9BWM5; -.
DR Reactome; REACT_71; Gene Expression.
DR GenomeRNAi; 55659; -.
DR NextBio; 60387; -.
DR Bgee; Q9BWM5; -.
DR CleanEx; HS_ZNF416; -.
DR Genevestigator; Q9BWM5; -.
DR GermOnline; ENSG00000083817; Homo sapiens.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 12.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 594 Zinc finger protein 416.
FT /FTId=PRO_0000233984.
FT DOMAIN 28 111 KRAB.
FT ZN_FING 242 264 C2H2-type 1; degenerate.
FT ZN_FING 270 292 C2H2-type 2.
FT ZN_FING 298 320 C2H2-type 3.
FT ZN_FING 326 348 C2H2-type 4.
FT ZN_FING 354 376 C2H2-type 5.
FT ZN_FING 382 404 C2H2-type 6.
FT ZN_FING 410 432 C2H2-type 7.
FT ZN_FING 438 460 C2H2-type 8.
FT ZN_FING 466 488 C2H2-type 9.
FT ZN_FING 494 516 C2H2-type 10.
FT ZN_FING 522 544 C2H2-type 11.
FT ZN_FING 550 572 C2H2-type 12.
FT CONFLICT 463 463 E -> I (in Ref. 2).
SQ SEQUENCE 594 AA; 67188 MW; 6ABC5ED049066C6D CRC64;
MAAAVLRDST SVPVTAEAKL MGFTQGCVTF EDVAIYFSQE EWGLLDEAQR LLYRDVMLEN
FALITALVCW HGMEDEETPE QSVSVEGVPQ VRTPEASPST QKIQSCDMCV PFLTDILHLT
DLPGQELYLT GACAVFHQDQ KHHSAEKPLE SDMDKASFVQ CCLFHESGMP FTSSEVGKDF
LAPLGILQPQ AIANYEKPNK ISKCEEAFHV GISHYKWSQC RRESSHKHTF FHPRVCTGKR
LYESSKCGKA CCCECSLVQL QRVHPGERPY ECSECGKSFS QTSHLNDHRR IHTGERPYVC
GQCGKSFSQR ATLIKHHRVH TGERPYECGE CGKSFSQSSN LIEHCRIHTG ERPYECDECG
KAFGSKSTLV RHQRTHTGEK PYECGECGKL FRQSFSLVVH QRIHTTARPY ECGQCGKSFS
LKCGLIQHQL IHSGARPFEC DECGKSFSQR TTLNKHHKVH TAERPYVCGE CGKAFMFKSK
LVRHQRTHTG ERPFECSECG KFFRQSYTLV EHQKIHTGLR PYDCGQCGKS FIQKSSLIQH
QVVHTGERPY ECGKCGKSFT QHSGLILHRK SHTVERPRDS SKCGKPYSPR SNIV
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