ID Q9C0P5_9EURO Unreviewed; 132 AA.
AC Q9C0P5;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Orotidine 5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00021923, ECO:0000256|RuleBase:RU000512};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321, ECO:0000256|RuleBase:RU000512};
DE Flags: Fragment;
GN Name=pyrG {ECO:0000313|EMBL:CAC35064.1};
OS Uncinocarpus reesii.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Uncinocarpus.
OX NCBI_TaxID=33188 {ECO:0000313|EMBL:CAC35064.1};
RN [1] {ECO:0000313|EMBL:CAC35064.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UAMH 160 {ECO:0000313|EMBL:CAC35064.1}, UAMH 1704
RC {ECO:0000313|EMBL:CAC35066.1}, UAMH 1706
RC {ECO:0000313|EMBL:CAC35065.1}, UAMH 1955
RC {ECO:0000313|EMBL:CAC35067.1}, and UAMH 2862
RC {ECO:0000313|EMBL:CAC35068.1};
RA Koufopanou V., Burt A., Szaro T., Taylor J.W.;
RT "Gene genealogies, cryptic species and molecular evolution in the human
RT pathogen Coccidioides immitis and relatives (Ascomycota, Onygenales).";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|RuleBase:RU000512};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861,
CC ECO:0000256|RuleBase:RU000512}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family.
CC {ECO:0000256|ARBA:ARBA00011018, ECO:0000256|RuleBase:RU000512}.
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DR EMBL; AJ292106; CAC35064.1; -; Genomic_DNA.
DR EMBL; AJ292107; CAC35065.1; -; Genomic_DNA.
DR EMBL; AJ292108; CAC35066.1; -; Genomic_DNA.
DR EMBL; AJ292109; CAC35067.1; -; Genomic_DNA.
DR EMBL; AJ292110; CAC35068.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9C0P5; -.
DR VEuPathDB; FungiDB:UREG_00820; -.
DR UniPathway; UPA00070; UER00120.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014732; OMPdecase.
DR InterPro; IPR018089; OMPdecase_AS.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR01740; pyrF; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR PROSITE; PS00156; OMPDECASE; 1.
PE 3: Inferred from homology;
KW Decarboxylase {ECO:0000256|ARBA:ARBA00022793,
KW ECO:0000256|RuleBase:RU000512};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000512};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975,
KW ECO:0000256|RuleBase:RU000512}.
FT DOMAIN 10..126
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|Pfam:PF00215"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAC35064.1"
FT NON_TER 132
FT /evidence="ECO:0000313|EMBL:CAC35064.1"
SQ SEQUENCE 132 AA; 14245 MW; 907DAA4881FB50EB CRC64;
DFSSETIAGL QSLSQKHNFL IFEDRKFVDI GNTVQKQYHG GALQISQWAH IVNATMLPGP
GIIDALAQVA SAPDFPHAAH RGLLILAEMT SKGSLATGKY TELSVEMARK YRGFVLGFVA
TRSLADVDTA AK
//
