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Database: UniProt
Entry: Q9C578
LinkDB: Q9C578
Original site: Q9C578 
ID   RCL1_ARATH              Reviewed;         375 AA.
AC   Q9C578;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   01-OCT-2014, entry version 93.
DE   RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN   OrderedLocusNames=At5g22100; ORFNames=T6G21.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
RA   Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
RA   Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
RA   Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
RA   Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
RA   Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
RA   Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
RA   Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
RA   Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
RA   Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
RA   Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
RA   Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
RA   Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
RA   Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
RA   van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
RA   Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
RA   Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
RA   Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RG   The Arabidopsis Information Resource (TAIR);
RL   Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC       ribosomal-subunit biogenesis in the early pre-rRNA processing
CC       steps at sites A0, A1 and A2 that are required for proper
CC       maturation of the 18S RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AL589883; CAC34503.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92983.1; -; Genomic_DNA.
DR   EMBL; BT002059; AAN72070.1; -; mRNA.
DR   RefSeq; NP_680196.1; NM_147891.3.
DR   UniGene; At.44338; -.
DR   UniGene; At.45633; -.
DR   ProteinModelPortal; Q9C578; -.
DR   SMR; Q9C578; 8-369.
DR   STRING; 3702.AT5G22100.1-P; -.
DR   PaxDb; Q9C578; -.
DR   PRIDE; Q9C578; -.
DR   EnsemblPlants; AT5G22100.1; AT5G22100.1; AT5G22100.
DR   GeneID; 832271; -.
DR   KEGG; ath:AT5G22100; -.
DR   TAIR; AT5G22100; -.
DR   eggNOG; COG0430; -.
DR   HOGENOM; HOG000157670; -.
DR   InParanoid; Q9C578; -.
DR   KO; K11108; -.
DR   OMA; FMKHPLR; -.
DR   PhylomeDB; Q9C578; -.
DR   BioCyc; ARA:GQT-208-MONOMER; -.
DR   PRO; PR:Q9C578; -.
DR   Genevestigator; Q9C578; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.65.10.20; -; 2.
DR   InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR   InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR   InterPro; IPR000228; RNA3'_term_phos_cyc.
DR   InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR   InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   PANTHER; PTHR11096; PTHR11096; 1.
DR   Pfam; PF01137; RTC; 1.
DR   Pfam; PF05189; RTC_insert; 1.
DR   PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR   PROSITE; PS01287; RTC; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN         1    375       Probable RNA 3'-terminal phosphate
FT                                cyclase-like protein.
FT                                /FTId=PRO_0000156442.
SQ   SEQUENCE   375 AA;  40874 MW;  3C7D286D4386D5AF CRC64;
     MVMMKKMKGS QSFRQRLLLS TLSSTPISID EIRADETIPG LRPHEVNLLR LLEIVTDDAV
     VDINETGTRL KYKPGTIVGG KNLVHSCSLS RSIGYYLEPL LLLGLFGKKP LSIRLKGITN
     DPRDASVDTF RSTTLNIIKR FGVPAEDLEL KIEARGVAPN GGGEVLLTVP NIKTLSAVHW
     VEEGMVKKIR GTTFSTRVTS DFEHSMRFAA RGIFNNLLPD VHIFQDHRAG AQAGKSPGYG
     ISLAAETTTG CFISADTTVS CERPDETGEL DVEKKERSPA EDTGVEVASW LLQEIEKGGV
     VDSTHQGLLF LLCALSEQDV SKVRVGTLSP YAVETLRNIK EFLGVKFAIK PDPLTGTVIL
     KCTGSGLINL SRKLS
//
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