ID SUVH7_ARATH Reviewed; 693 AA.
AC Q9C5P1; Q9LMU9;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 01-MAY-2013, entry version 90.
DE RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH7;
DE EC=2.1.1.43;
DE AltName: Full=Histone H3-K9 methyltransferase 7;
DE Short=H3-K9-HMTase 7;
DE AltName: Full=Protein SET DOMAIN GROUP 17;
DE AltName: Full=Suppressor of variegation 3-9 homolog protein 7;
DE Short=Su(var)3-9 homolog protein 7;
GN Name=SUVH7; Synonyms=SDG17, SET17; OrderedLocusNames=At1g17770;
GN ORFNames=F2H15.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND NOMENCLATURE.
RX PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT "The Arabidopsis thaliana genome contains at least 29 active genes
RT encoding SET domain proteins that can be assigned to four
RT evolutionarily conserved classes.";
RL Nucleic Acids Res. 29:4319-4333(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RG The Arabidopsis Information Resource (TAIR);
RL Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY.
RX PubMed=16384625; DOI=10.1016/j.jplph.2005.10.015;
RA Fischer A., Hofmann I., Naumann K., Reuter G.;
RT "Heterochromatin proteins and the control of heterochromatic gene
RT silencing in Arabidopsis.";
RL J. Plant Physiol. 163:358-368(2006).
CC -!- FUNCTION: Histone methyltransferase. Methylates 'Lys-9' of histone
CC H3. H3 'Lys-9' methylation represents a specific tag for
CC epigenetic transcriptional repression.
CC -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Chromosome,
CC centromere (By similarity). Note=Associates with centromeric
CC constitutive heterochromatin (By similarity).
CC -!- DOMAIN: Although the SET domain contains the active site of
CC enzymatic activity, both pre-SET and post-SET domains are required
CC for methyltransferase activity.
CC -!- SIMILARITY: Belongs to the histone-lysine methyltransferase
CC family. Suvar3-9 subfamily.
CC -!- SIMILARITY: Contains 1 A.T hook DNA-binding domain.
CC -!- SIMILARITY: Contains 1 post-SET domain.
CC -!- SIMILARITY: Contains 1 pre-SET domain.
CC -!- SIMILARITY: Contains 1 SET domain.
CC -!- SIMILARITY: Contains 1 YDG domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF97258.1; Type=Erroneous gene model prediction;
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DR EMBL; AF344450; AAK28972.1; -; mRNA.
DR EMBL; AC034106; AAF97258.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29634.1; -; Genomic_DNA.
DR IPI; IPI00542064; -.
DR PIR; G86312; G86312.
DR RefSeq; NP_564036.1; NM_101640.1.
DR UniGene; At.15818; -.
DR ProteinModelPortal; Q9C5P1; -.
DR SMR; Q9C5P1; 226-378, 403-691.
DR PaxDb; Q9C5P1; -.
DR PRIDE; Q9C5P1; -.
DR EnsemblPlants; AT1G17770.1; AT1G17770.1; AT1G17770.
DR GeneID; 838355; -.
DR KEGG; ath:AT1G17770; -.
DR TAIR; At1g17770; -.
DR eggNOG; COG3440; -.
DR HOGENOM; HOG000238382; -.
DR InParanoid; Q9C5P1; -.
DR KO; K11420; -.
DR OMA; QVSEFIN; -.
DR PhylomeDB; Q9C5P1; -.
DR ProtClustDB; CLSN2687844; -.
DR Genevestigator; Q9C5P1; -.
DR GermOnline; AT1G17770; Arabidopsis thaliana.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.30.280.10; -; 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR025794; Hist-Lys_N-MeTrfase_plant.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR003105; SRA_YDG.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF02182; YDG_SRA; 1.
DR SMART; SM00384; AT_hook; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SMART; SM00466; SRA; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS51015; YDG; 1.
PE 2: Evidence at transcript level;
KW Centromere; Chromatin regulator; Chromosome; Complete proteome;
KW DNA-binding; Methyltransferase; Nucleus; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1 693 Histone-lysine N-methyltransferase, H3
FT lysine-9 specific SUVH7.
FT /FTId=PRO_0000186078.
FT DOMAIN 227 373 YDG.
FT DOMAIN 454 516 Pre-SET.
FT DOMAIN 518 664 SET.
FT DOMAIN 677 693 Post-SET.
FT DNA_BIND 129 141 A.T hook.
SQ SEQUENCE 693 AA; 77632 MW; E03E22BC2863E2D7 CRC64;
MDKSIPIKAI PVACVRPDLV DDVTKNTSTI PTMVSPVLTN MPSATSPLLM VPPLRTIWPS
NKEWYDGDAG PSSTGPIKRE ASDNTNDTAH NTFAPPPEMV IPLITIRPSD DSSNYSCDAG
AGPSTGPVKR GRGRPKGSKN STPTEPKKPK VYDPNSLKVT SRGNFDSEIT EAETETGNQE
IVDSVMMRFD AVRRRLCQIN HPEDILTTAS GNCTKMGVKT NTRRRIGAVP GIHVGDIFYY
WGEMCLVGLH KSNYGGIDFF TAAESAVEGH AAMCVVTAGQ YDGETEGLDT LIYSGQGGTD
VYGNARDQEM KGGNLALEAS VSKGNDVRVV RGVIHPHENN QKIYIYDGMY LVSKFWTVTG
KSGFKEFRFK LVRKPNQPPA YAIWKTVENL RNHDLIDSRQ GFILEDLSFG AELLRVPLVN
EVDEDDKTIP EDFDYIPSQC HSGMMTHEFH FDRQSLGCQN CRHQPCMHQN CTCVQRNGDL
LPYHNNILVC RKPLIYECGG SCPCPDHCPT RLVQTGLKLH LEVFKTRNCG WGLRSWDPIR
AGTFICEFAG LRKTKEEVEE DDDYLFDTSK IYQRFRWNYE PELLLEDSWE QVSEFINLPT
QVLISAKEKG NVGRFMNHSC SPNVFWQPIE YENRGDVYLL IGLFAMKHIP PMTELTYDYG
VSCVERSEED EVLLYKGKKT CLCGSVKCRG SFT
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