ID Q9CB72_MYCLE Unreviewed; 732 AA.
AC Q9CB72;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 124.
DE SubName: Full=Possible regulatory protein {ECO:0000313|EMBL:CAC31857.1};
GN OrderedLocusNames=ML2341 {ECO:0000313|EMBL:CAC31857.1};
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631 {ECO:0000313|EMBL:CAC31857.1, ECO:0000313|Proteomes:UP000000806};
RN [1] {ECO:0000313|EMBL:CAC31857.1, ECO:0000313|Proteomes:UP000000806}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN {ECO:0000313|EMBL:CAC31857.1,
RC ECO:0000313|Proteomes:UP000000806};
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL583925; CAC31857.1; -; Genomic_DNA.
DR PIR; A87202; A87202.
DR RefSeq; NP_302524.1; NC_002677.1.
DR AlphaFoldDB; Q9CB72; -.
DR STRING; 272631.gene:17576203; -.
DR KEGG; mle:ML2341; -.
DR PATRIC; fig|272631.5.peg.4491; -.
DR Leproma; ML2341; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR HOGENOM; CLU_448264_0_0_11; -.
DR OMA; WATNRDI; -.
DR OrthoDB; 5476461at2; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000806}.
FT DOMAIN 41..172
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 732 AA; 78380 MW; 1DF39AF109F39AD1 CRC64;
MTTALVCVAC GAELRSIAKF CDECGSPVVE AETPAEYKQV TVLFADVVGS MDIAAAVGLE
RLREIMTELV SRAAGVIERY GGTVDKFTGD GIMAIFGAPT ALEDHALRAC LAALGVQEKA
RRLAAEVGDR DGVDLQLRVG LNSGQVIVGE IGSSALGYTA VGVQVGMAQR MESVAPPGVV
MLSESTARLV EQTAVLGAPQ TVRIKGAEDA VPARRLLRVA EPRQPTWFSE STLVGREWEL
ATLAAMLDRS IGGRGSVVGL VGPAGIGKTR LVAEAVQLAK GLEVEVFSVF CESHATDVAF
DVVAQLVRAV AQISGLDDRS ARARVREQIP DADTQDLLLL DDLLGIADPA VELPRLDPDA
RRRRLTALIN VAQLALSRPA VFVVEDVHWI DEVSDSMLAD FLAVIPQTRS MALVTYRPEY
HGALRHVVGA QIIAVAPLSD VETSTLVAEL LGLDQSVTQI GELITERAAG NPFFAQEITR
ELAERGVLTG ERGRYACSTD VAEVCVPATL QATIAARIDR LSPPAKQLLV AAAVIGFRFG
SDLLASLGID LSVDELIDAN LVDQVRFTAP VEYAFRHPLI RTVAYESQLK SDRARLHRRL
AAAIEARAPH SVDQHAVLIA EHLEAAGDLH AAYGWHMRAA AWATNQDVRA ARVSWEHATK
IADALTAEDP HRAAMCIAPR TRLCGIAWRG RFNSSSGFDE VRQLCNATGD KAPLAVATVG
PAIDHVYQDR LH
//