ID MTRA_MYCLE Reviewed; 225 AA.
AC Q9CCJ2;
DT 25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT 25-MAR-2003, sequence version 2.
DT 01-MAY-2013, entry version 69.
DE RecName: Full=DNA-binding response regulator MtrA;
GN Name=mtrA; OrderedLocusNames=ML0773;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: Member of the two-component regulatory system MtrA/MtrB
CC (By similarity).
CC -!- PTM: Phosphorylated by MtrB (Probable).
CC -!- SIMILARITY: Contains 1 response regulatory domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC30282.1; Type=Erroneous initiation;
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DR EMBL; AL583919; CAC30282.1; ALT_INIT; Genomic_DNA.
DR PIR; F87005; F87005.
DR RefSeq; NP_301597.1; NC_002677.1.
DR ProteinModelPortal; Q9CCJ2; -.
DR SMR; Q9CCJ2; 1-225.
DR STRING; 272631.ML0773; -.
DR EnsemblBacteria; CAC30282; CAC30282; CAC30282.
DR GeneID; 909727; -.
DR KEGG; mle:ML0773; -.
DR PATRIC; 18052890; VBIMycLep78757_1391.
DR Leproma; ML0773; -.
DR eggNOG; COG0745; -.
DR HOGENOM; HOG000034819; -.
DR KO; K07670; -.
DR ProtClustDB; CLSK872159; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:GOC.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR011991; WHTH_DNA-bd_dom.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; CheY_like; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Complete proteome; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system.
FT CHAIN 1 225 DNA-binding response regulator MtrA.
FT /FTId=PRO_0000081141.
FT DOMAIN 1 117 Response regulatory.
FT MOD_RES 53 53 4-aspartylphosphate (By similarity).
SQ SEQUENCE 225 AA; 24927 MW; B04A11DA2C5CECCF CRC64;
MRQRILVVDD DASLAEMLTI VLRGEGFDTA VIGDGTQALT AVRELRPDLV LLDLMLPGMN
GIDVCRVLRA DSGVPIVMLT AKTDTVDVVL GLESGADDYI MKPFKPKELV ARVRARLRRN
DDEPAEMLSI ADVDIDVPAH KVTRNGEHIS LTPLEFDLLV ALARKPRQVF TRDVLLEQVW
GYRHPADTRL VNVHVQRLRA KVEKDPENPT VVLTVRGVGY KAGPP
//
