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Database: UniProt
Entry: Q9CCJ2
LinkDB: Q9CCJ2
Original site: Q9CCJ2 
ID   MTRA_MYCLE              Reviewed;         225 AA.
AC   Q9CCJ2;
DT   25-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   25-MAR-2003, sequence version 2.
DT   01-OCT-2014, entry version 75.
DE   RecName: Full=DNA-binding response regulator MtrA;
GN   Name=mtrA; OrderedLocusNames=ML0773;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system MtrA/MtrB.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated by MtrB. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 response regulatory domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00169}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC30282.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL583919; CAC30282.1; ALT_INIT; Genomic_DNA.
DR   PIR; F87005; F87005.
DR   RefSeq; NP_301597.1; NC_002677.1.
DR   ProteinModelPortal; Q9CCJ2; -.
DR   SMR; Q9CCJ2; 1-225.
DR   STRING; 272631.ML0773; -.
DR   EnsemblBacteria; CAC30282; CAC30282; CAC30282.
DR   GeneID; 909727; -.
DR   KEGG; mle:ML0773; -.
DR   PATRIC; 18052890; VBIMycLep78757_1391.
DR   Leproma; ML0773; -.
DR   eggNOG; COG0745; -.
DR   HOGENOM; HOG000034819; -.
DR   KO; K07670; -.
DR   OrthoDB; EOG6G4VQG; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; Sig_transdc_resp-reg_C.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR011991; WHTH_DNA-bd_dom.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Complete proteome; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN         1    225       DNA-binding response regulator MtrA.
FT                                /FTId=PRO_0000081141.
FT   DOMAIN        1    117       Response regulatory.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
FT   MOD_RES      53     53       4-aspartylphosphate.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00169}.
SQ   SEQUENCE   225 AA;  24927 MW;  B04A11DA2C5CECCF CRC64;
     MRQRILVVDD DASLAEMLTI VLRGEGFDTA VIGDGTQALT AVRELRPDLV LLDLMLPGMN
     GIDVCRVLRA DSGVPIVMLT AKTDTVDVVL GLESGADDYI MKPFKPKELV ARVRARLRRN
     DDEPAEMLSI ADVDIDVPAH KVTRNGEHIS LTPLEFDLLV ALARKPRQVF TRDVLLEQVW
     GYRHPADTRL VNVHVQRLRA KVEKDPENPT VVLTVRGVGY KAGPP
//
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