ID Q9CGC9_LACLA Unreviewed; 752 AA.
AC Q9CGC9;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Radical SAM core domain-containing protein {ECO:0000259|PROSITE:PS51918};
GN Name=yliB {ECO:0000313|EMBL:AAK05266.1};
GN ORFNames=L180742 {ECO:0000313|EMBL:AAK05266.1};
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623 {ECO:0000313|EMBL:AAK05266.1, ECO:0000313|Proteomes:UP000002196};
RN [1] {ECO:0000313|EMBL:AAK05266.1, ECO:0000313|Proteomes:UP000002196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403 {ECO:0000313|EMBL:AAK05266.1,
RC ECO:0000313|Proteomes:UP000002196};
RX PubMed=11337471; DOI=10.1101/gr.GR-1697R;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE005176; AAK05266.1; -; Genomic_DNA.
DR PIR; H86770; H86770.
DR RefSeq; NP_267324.1; NC_002662.1.
DR RefSeq; WP_003132130.1; NC_002662.1.
DR AlphaFoldDB; Q9CGC9; -.
DR PaxDb; 272623-L180742; -.
DR EnsemblBacteria; AAK05266; AAK05266; L180742.
DR KEGG; lla:L180742; -.
DR PATRIC; fig|272623.7.peg.1249; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_369986_0_0_9; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002196}.
FT DOMAIN 288..519
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 752 AA; 87436 MW; 36BB4DAEC6B4BCA8 CRC64;
MMKSMLIFPP GWDPRGPYLS LPVLKAYLQQ NNQEVLIRDE NVEFYDFFFS EQFFKRMSRE
TSTLKKSIYF NSTLHIQEAK DVIRSKDSKS WQRKFAWNVL SNLNYLAGKV YKGFEIDFNS
MHFKYSHDST SEIMKALSDR AANPLIEYFE KDCSTIEEIK NQEIEYIGFS VTGNTQLIPT
LTMCKAIKEL CPSVKHIQLG GNFITRISSL IGNLHPFWNY IDSMLLYDGE ENLSSFLQQL
ENNKDYSNIP NLYYLDDHRN LKRNEIVESK TINSLPPDFD GFDFSKYFTD NLWIPIYTSR
ACVNKSTFCT IPNASGGKFR HMPAKKVVEN MEVVKEKYGI SHFSFVDETF LVPKMKQIAK
LLIDNEQKDI SWYCETRFSK LLTADTTQIL RKGGCSNIQF GLESYNQRVL DLMDKNIDIA
WIEPNIINCF EAGISVHLFF MTGFPTETLE EAKNTYHFAN EMILKSKKDY GLPYSTKGFG
TFGLKVGAGV YEKPEVFNIE ILEPADDEDL RLSRDYNIHE GLTSDEAKQL VSTMRSSKIS
LQTSFDAQQF DIEFPKSILP SEIDLINERE KRAAERSYKV YGFCFENESL KINRYVSLII
DEETQMTLLY NVKHGIFLSY PTSDLQIGNA KITFALDNIK SDLAYYDFLE LENSQEKYST
MDEIFEGKYK LCLNDYFFEH YNSTDLLIYN KMFKEVIQTN VLGHELLKYF TISHKIQEWF
TEITRSGLNL PVEKLEKLIV DALESKVLKV MI
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