ID ANR61_MOUSE Reviewed; 421 AA.
AC Q9CQM6; Q80W77;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 144.
DE RecName: Full=Ankyrin repeat domain-containing protein 61;
GN Name=Ankrd61;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQM6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQM6-2; Sequence=VSP_032775;
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DR EMBL; AK014929; BAB29624.1; -; mRNA.
DR EMBL; AK017053; BAB30569.1; -; mRNA.
DR EMBL; BC052346; AAH52346.1; -; mRNA.
DR CCDS; CCDS39373.1; -. [Q9CQM6-1]
DR CCDS; CCDS80460.1; -. [Q9CQM6-2]
DR RefSeq; NP_001297701.1; NM_001310772.1. [Q9CQM6-2]
DR RefSeq; NP_080008.1; NM_025732.4. [Q9CQM6-1]
DR AlphaFoldDB; Q9CQM6; -.
DR SMR; Q9CQM6; -.
DR STRING; 10090.ENSMUSP00000106345; -.
DR iPTMnet; Q9CQM6; -.
DR PhosphoSitePlus; Q9CQM6; -.
DR SwissPalm; Q9CQM6; -.
DR PaxDb; 10090-ENSMUSP00000106345; -.
DR ProteomicsDB; 282121; -. [Q9CQM6-1]
DR ProteomicsDB; 282122; -. [Q9CQM6-2]
DR Antibodypedia; 49311; 57 antibodies from 12 providers.
DR DNASU; 66729; -.
DR Ensembl; ENSMUST00000079624.12; ENSMUSP00000078571.6; ENSMUSG00000029607.15. [Q9CQM6-2]
DR Ensembl; ENSMUST00000110717.9; ENSMUSP00000106345.3; ENSMUSG00000029607.15. [Q9CQM6-1]
DR GeneID; 66729; -.
DR KEGG; mmu:66729; -.
DR UCSC; uc009akv.1; mouse. [Q9CQM6-1]
DR AGR; MGI:1913979; -.
DR CTD; 100310846; -.
DR MGI; MGI:1913979; Ankrd61.
DR VEuPathDB; HostDB:ENSMUSG00000029607; -.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00840000130004; -.
DR HOGENOM; CLU_054056_0_0_1; -.
DR InParanoid; Q9CQM6; -.
DR OMA; AINESSM; -.
DR OrthoDB; 1378723at2759; -.
DR PhylomeDB; Q9CQM6; -.
DR TreeFam; TF352214; -.
DR BioGRID-ORCS; 66729; 2 hits in 76 CRISPR screens.
DR PRO; PR:Q9CQM6; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CQM6; Protein.
DR Bgee; ENSMUSG00000029607; Expressed in seminiferous tubule of testis and 39 other cell types or tissues.
DR ExpressionAtlas; Q9CQM6; baseline and differential.
DR Genevisible; Q9CQM6; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24197; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61; 1.
DR PANTHER; PTHR24197:SF48; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 61; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 2: Evidence at transcript level;
KW Alternative splicing; ANK repeat; DNA-binding; Reference proteome; Repeat.
FT CHAIN 1..421
FT /note="Ankyrin repeat domain-containing protein 61"
FT /id="PRO_0000328763"
FT REPEAT 27..57
FT /note="ANK 1"
FT REPEAT 74..103
FT /note="ANK 2"
FT REPEAT 107..146
FT /note="ANK 3"
FT REPEAT 166..195
FT /note="ANK 4"
FT REPEAT 199..228
FT /note="ANK 5"
FT REPEAT 233..272
FT /note="ANK 6"
FT REPEAT 276..305
FT /note="ANK 7"
FT REPEAT 309..342
FT /note="ANK 8"
FT VAR_SEQ 1..71
FT /note="MGNITKRGSRDLVADGATLVEESLATTLHSKLYEAIIKEDCNTIKTLLRNHP
FT VNQPLTILANSTRYRLLSQ -> MDGWNTACVAGRRVPSSSQNTPTATMSCK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032775"
SQ SEQUENCE 421 AA; 46588 MW; 7610ACAEA9A36654 CRC64;
MGNITKRGSR DLVADGATLV EESLATTLHS KLYEAIIKED CNTIKTLLRN HPVNQPLTIL
ANSTRYRLLS QQTQPIFPIH LAAEYRKPQS LLCLLQHGAD PEVRDAQGFT TLHLMLLNWP
ASSTTWSKPS TQIQKILMDI QNNAVLCLCI LCDHGAQVNA RVDNSNKHSA LHLAIIHGTY
PVLSFLAQNG AQVNATNESS MTPLHMAADI LNKNMIETLI AFGANVNCAI SSTGNTALKL
AVCTASSKVG RLLAAGVGCI RLLLNNGAQV NAQDHEGQTA LHEACFGGRE AIISLLLEFE
ANVNILTRNG ESPIYMYLQR SSNIRDRSLL ARLLYRTYPL RLSNKQGILP AGIMLPEYQL
LRETLVKLSK KPLTLEAICK RSIRNVYGEK YKFHLEKLLP AKLWNSIYGI YDLTYLLKGE
P
//
